Application of brain-derived neurotrophic factor in preparing medicine for preventing and treating propofol addiction

A technology of neurotrophic factor and propofol, which is applied in the field of medicine, can solve the problems of propofol abuse and imperfect control, and achieve remarkable effects, good industrialization prospects, and safe and stable application

Pending Publication Date: 2020-10-30
连庆泉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, in recent years, the U.S. Drug Enforcement Administration has included propofol in the list of controlled drugs, but the management ...

Method used

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  • Application of brain-derived neurotrophic factor in preparing medicine for preventing and treating propofol addiction
  • Application of brain-derived neurotrophic factor in preparing medicine for preventing and treating propofol addiction
  • Application of brain-derived neurotrophic factor in preparing medicine for preventing and treating propofol addiction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1: Propofol can increase the excitability of cells in the mPFC area to produce addictive behavior, which is mainly related to the decrease of BDNF content in this area

[0034] The present invention first detects that long-term repeated injection of propofol can induce propofol self-administration behavior in rats, which is mainly related to the increase of neuron excitability in cortical mPFC area. Select 16 healthy male SD rats aged 7-8 weeks and divide them into two groups: propofol group and normal saline control group. The external jugular vein catheterization operation was performed on them. Dosing training. During the training process, the computer automatically records the number of effective nasal touch pump injections of the rats, so as to observe its own drug administration training situation. After the training, anesthetize with isoflurane and perfuse the NMDG liquid mixed with ice water to take the brain, cut the rat brain into coronal slices with ...

Embodiment 2

[0037] Embodiment 2: BDNF can suppress the excitability of propofol addiction rat mPFC area cell

[0038]The present invention first detects that long-term repeated injection of propofol can successfully establish propofol self-administration behavior, which is mainly related to the increased excitability of neurons in the mPFC area of ​​the cortex. Select 16 healthy male SD rats aged 7-8 weeks and divide them into two groups: propofol group and normal saline control group. The external jugular vein catheterization operation was performed on them. Dosing training. During the training process, the computer automatically records the number of effective nasal touch pump injections of the rats, so as to observe its own drug administration training situation. After the training, anesthetize with isoflurane and perfuse the NMDG liquid mixed with ice water to take the brain, cut the rat brain into coronal slices with a thickness of 300um in a vibrating microtome, and collect the bra...

Embodiment 3

[0041] Embodiment 3: BDNF can suppress propofol self-administration behavior in rats

[0042] In Examples 1 and 2, the present invention found that the formation of propofol-addicted rats' addictive behavior may be related to the increased excitability of cells in the mPFC area and the reduction of BDNF protein content in this area, and this increased excitability can be suppressed by BDNF. Antagonized. In this example, the inventors found that after exogenously increasing the content of BDNF protein in the mPFC region, the self-administration behavior of propofol in rats was inhibited. Eighteen healthy male SD rats at the age of 7-8 weeks were used to implant intracerebral administration tubes in the mPFC region under the stereotaxic instrument for injection of BDNF or solvent-controlled ACSF, and self-administration of propofol for 14 days. medicine training. The successfully trained rats were randomly divided into two groups: normal control group and BDNF group. After th...

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Abstract

The invention discloses an application of a brain-derived neurotrophic factor (BDNF) in preparation of a medicine for preventing and treating propofol addiction. The invention fully proves that SD rats can generate addiction behaviors after long-term repeated use of propofol, and the addiction behaviors are mainly caused by increased excitability of neurons of the forehead cortex of the brain, especially the forehead cortex of the inner side (mPFC area); and the BDNF can effectively inhibit the highly excited state of cells in the mPFC region of the cortex caused by propofol, thereby inhibiting the propofol addiction behavior of rats. The invention provides an effective treatment means for treating the symptoms of addiction and excitability of propofol addiction, has a good effect, and isexpected to fundamentally treat propofol addiction behaviors.

Description

technical field [0001] The invention relates to the application of brain-derived neurotrophic factor in the prevention and treatment of propofol addiction, in particular to its application in the preparation of drugs for the prevention and treatment of propofol addiction, and belongs to the field of medical technology. Background technique [0002] Propofol (propofol) is widely used in clinical anesthesia, painless outpatient clinics, and sedation of ICU patients due to its advantages of rapid onset of action, rapid elimination, and no accumulation. It is the most commonly used intravenous anesthetic. With the widespread use of propofol, some potential problems have gradually been paid attention to: some patients experience pleasure, excitement and euphoria after use. Animal experiments have proved that it is highly addictive, and there have been many reports of propofol addiction and death due to overdose injection. Propofol has the potential to be considered a new drug ag...

Claims

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Application Information

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IPC IPC(8): A61K38/18A61P25/30
CPCA61K38/18A61P25/30
Inventor 连庆泉
Owner 连庆泉
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