Preparation method of antibacterial silkworm cocoon-based wound dressing

A wound dressing and antibacterial technology, which is applied in the field of preparation of antibacterial cocoon-based wound dressings, can solve the problems of disrupting electrolyte balance, inability to kill bacteria, slow antibacterial effect, etc., and achieve softness, good transparency, and good shape , Excellent antibacterial properties

Active Publication Date: 2020-10-30
JIANGSU UNIV OF SCI & TECH
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  • Application Information

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Problems solved by technology

The antibacterial agent represented by silver series belongs to the contact reaction antibacterial mechanism. When a small amount of silver ion reaches the microbial cell, because the latter is negatively charged, the two are firmly adsorbed by Coulomb gravity, thereby destroying its electrolyte balance, causing the microorganism to be absorbed by the cell wall. Damaged and killed; the disadvantage is that the price is high and the antibacterial effect is slow, and it cannot kill bacteria as quickly as organic antibacterial agents

Method used

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  • Preparation method of antibacterial silkworm cocoon-based wound dressing
  • Preparation method of antibacterial silkworm cocoon-based wound dressing
  • Preparation method of antibacterial silkworm cocoon-based wound dressing

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Embodiment 1

[0036] A preparation method for an antibacterial cocoon-based wound dressing, comprising the following steps:

[0037] a) Preparation of silkworm cocoon membrane—use a ternary solution (molar ratio; water: calcium chloride: alcohol = 8:1:2) to treat the silkworm cocoon in a water bath to obtain a soft and transparent silkworm cocoon membrane;

[0038] First add 648ml of deionized water to 500g of calcium chloride, after the calcium chloride solution is cooled and the calcium chloride is completely dissolved, then add 525ml of alcohol, and complete the preparation of the ternary solution after the solution is sub-cooled. Then, completely infiltrate the cocoon with the silkworm chrysalis removed in the ternary solution, that is, pour an appropriate amount of ternary solution into the filter bottle containing the cocoon, and then shake the filter bottle to make the surface of the cocoon infiltrate. After the infiltration is complete, pour it out. The ternary solution, refill the ...

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Abstract

The invention provides a preparation method of an antibacterial silkworm cocoon-based wound dressing. Natural silkworm cocoons are used as starting materials, the preparation method comprises the following steps: firstly, obtaining a silkworm cocoon film with softness, transparency and ductility on the basis of reserving a silkworm cocoon natural structure, firstly preparing sericin, then reducingchloroauric acid in situ through reducibility of the sericin to obtain a silkworm cocoon membrane loaded with nanogold, then utilizing the specific action between the nanogold and sulfydryl, enablingthe silkworm cocoon membrane to obtain antibacterial property through self-assembly of the nanogold and 2-sulfydryl-1-methylimidazole (MMT), and finally obtaining the transparent and soft silkworm cocoon membrane with stable antibacterial property. The preparation method is simple and suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of medical dressings, and in particular relates to a preparation method of an antibacterial cocoon-based wound dressing. Background technique [0002] Wound healing is one of the most basic and important things in human history, however, currently in clinical practice, wound infection caused by bacteria is still an urgent problem to be solved. On the one hand, wound infection will delay wound healing; on the other hand, wound infection is also an important cause of high probability of morbidity and death in patients. Therefore, it is urgent to solve the problem of wound infection. As an important material in the wound healing process, wound dressings play an important role in covering the wound, protecting the wound from external bacterial infection, releasing drugs, and accelerating wound healing. Therefore, preparing an antibacterial wound dressing has become an important way to solve the problem of woun...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/18A61L15/20A61L15/32A61L15/46A61L15/40A61L15/42
CPCA61L15/18A61L15/20A61L15/32A61L15/46A61L15/40A61L15/42A61L2300/102A61L2300/216A61L2300/404A61L2400/12C08L89/00
Inventor 钱平巫蓉张业顺
Owner JIANGSU UNIV OF SCI & TECH
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