Nasal cavity internal drug administration device for tree shrews

Abstract

The invention discloses a nasal cavity internal drug administration device for tree shrews, and mainly relates to the field of nasal drug administration of experimental animals. The device comprises adeveloping device, an external insertion hose, a medicine injection inner sleeve hose and a flow choking device, wherein the external insertion hose comprises a middle hose cavity and an annular cleaning cavity, a cleaning through hole is formed in the top surface of the head of the external insertion hose head, and a medicine injection short pipe is arranged at the side part of the head of the external insertion hose; the developing device is arranged in the center of the top surface of the head of the external insertion hose; and a medicine injection opening is formed in the side part of the hose head of the medicine injection inner sleeve hose. The device has the beneficial effects that the device is suitable for drug administration for a nasal disease model of a tree shrew, the intubation position in the nasal cavity can be tracked in real time, the intubation position is determined, and the drug administration position is more accurate. In addition, in the propelling process, nasal fluid can be removed and cleaned in real time, and insertion of an intubation tube is facilitated. During drug medication, injected liquid medicines can be prevented from flowing into digestive tracts, so that the injection dosage is more accurate.

Description

technical field [0001] The invention relates to the field of nasal drug delivery for experimental animals, in particular to a drug delivery device inside the nasal cavity of tree shrews. Background technique [0002] The tree shrew is a new type of experimental animal. It is small in size, reproduces quickly, and has a closer relationship with primates than traditional experimental animals (rats, mice, rabbits, etc.), and was considered a low-level primate in the past. Animals; therefore, it has a wide range of applications in the field of biomedicine, especially its role in animal models of human diseases has attracted more and more attention. For the research of different diseases, it is often necessary to use different routes of administration; for the creation of nasal disease models, usually the administration site is limited to the local part of the nose to obtain the ideal model effect. However, tree shrews have a complex nasal structure, turbinates and sinuses occup...

AI Technical Summary

Problems solved by technology

[0004] 1. The hose has no scale, and the insertion depth cannot be known, so it is impossible to guess the final administration site, which may lead to inaccurate administration sites

[0005] 2. The medicine liquid directly output through the hose may flow into the digestive tract through the back nostril, and the loss of the medicine liquid will lead to inaccurate local drug injection dosage

[0006] 3. There is a lot of nasal fluid in the nasal cavity of tree shrews. The nasal fluid is relatively thick and the plastic hose is soft. During the continuous insertion process, it will push the nasal fluid to accumulate inward and increase the resistance, thus hindering the further insertion of the plastic hose. make the whole insertion process difficult

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