Wound covering and preparation method thereof

A covering and wound technology, which is applied in the field of wound covering and its preparation, can solve the problems of long healing time and lack of biological activity of the wound, and achieve the effect of accelerating tissue epithelialization, excellent mechanical strength and good biocompatibility

Active Publication Date: 2020-11-27
ZHENDE MEDICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a good mechanical dressing to solve the defects that the existing dressing does not have biological activity, the wound healing time is long, and the wound needs to b

Method used

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  • Wound covering and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The present invention provides a kind of preparation method of wound cover, comprises the following steps:

[0035] 1) Construction of collagen-mussel mucin film

[0036] 1) Take mussel mucin and dissolve it in 0.0001mol / L glacial acetic acid solution to prepare a mussel mucin stock solution with a concentration of 0.4%;

[0037] 2) Take 5 parts of the above-mentioned stock solution and dilute to 20 parts with water; dissolve the collagen in the above-mentioned mussel mucin glacial acetic acid aqueous solution, fully stir and dissolve, so that the concentration of the collagen is 0.5%, and the concentration of the mussel mucin is 0.1%. ;

[0038] 3) Pour the above solution into a 30*30cm stainless steel plate, the solution height is 5mm; put the stainless steel plate into a freeze dryer, and vacuum freeze-dry it at -10°C and 10-50Pa for 10 hours; then quickly put the plate layer The temperature is raised to 10°C, and the system pressure is adjusted to 300-500Pa (befor...

Embodiment 2

[0045] The present invention provides a kind of preparation method of wound cover, comprises the following steps:

[0046] 1) Construction of collagen-mussel mucin film

[0047] 1) Take mussel mucin and dissolve it in 0.0001mol / L glacial acetic acid solution to prepare a mussel mucin stock solution with a concentration of 0.4%;

[0048] 2) Take 5 parts of the above stock solution and dilute to 20 parts with water; dissolve the collagen in the above-mentioned mussel mucin glacial acetic acid aqueous solution, fully stir and dissolve, so that the collagen concentration is 0.3%, and the mussel mucin concentration is 0.1%. ;

[0049] 3) Inject the above solution into a 30*30cm stainless steel plate with a solution height of 12.5mm; put the stainless steel plate into a freeze dryer, and vacuum freeze-dry it at -10°C and 10-50Pa for 15 hours; then quickly place the plate The temperature of the layer is raised to 10°C, and the system pressure is adjusted to 300-500Pa, so that before ...

Embodiment 3

[0056] The present invention provides a kind of preparation method of wound cover, comprises the following steps:

[0057] 1) Construction of collagen-mussel mucin film

[0058] 1) Take mussel mucin and dissolve it in 0.0001mol / L glacial acetic acid solution to prepare a mussel mucin stock solution with a concentration of 0.4%;

[0059] 2) Take 1 part of the above-mentioned stock solution and dilute it to 20 parts with water; dissolve the collagen in the above-mentioned mussel mucin glacial acetic acid aqueous solution, fully stir and dissolve, so that the concentration of the collagen is 0.4%, and the concentration of the mussel mucin is 0.02%. ;

[0060] 3) Inject the above solution into a 30*30cm stainless steel plate with a solution height of 2.4mm; put the stainless steel plate into a freeze dryer, and vacuum freeze-dry it at -10°C and 10-50Pa for 7 hours; then quickly place the plate The temperature of the layer is raised to 10°C, and the system pressure is adjusted to...

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Abstract

The invention relates to a wound covering good in biocompatibility and capable of accelerating wound healing and a preparation method of the wound covering. The wound covering comprises a film sheet,and the film sheet is prepared from a carrier with good biocompatibility and high mechanical strength and protein containing dopa groups; the carrier is collagen, and the protein containing the dopa group is mussel mucin. The collagen is mixed with mussel mucin, a dry membrane is prepared by a semi-freeze-drying method under a low-temperature condition, the mussel mucin is immobilized on the collagen through chemical crosslinking, residual cross-linking agents are removed through rinsing, then the mussel mucin is stored in a preservation solution, the stability of the protein structure is enhanced, the activity of the collagen and the mussel mucin is maintained, and a collagen matrix has excellent mechanical strength and can be trimmed into any shape; tissue epithelialization can be accelerated, and wound healing is promoted; and the biocompatibility is good, the wound surface is not adhered, and secondary injury to the wound surface is avoided.

Description

technical field [0001] The invention relates to a medical material, in particular to a wound covering which has good biocompatibility and can accelerate wound healing and a preparation method thereof. Background technique [0002] The main function of medical dressings is to cover and protect damaged skin, and at the same time provide an environment conducive to wound healing. It should not stimulate the human body, and will not cause poisoning and disease. [0003] Existing solutions mostly use Vaseline oil gauze, hydrocolloid dressings and other non-biologically active dressings to cover the skin donor area or burn wounds, but its defects are: (1) the wound healing time is long; (2) the wound surface during treatment Multiple dressing changes are required, which can cause hemorrhage of new granulation tissue and pain in patients. Contents of the invention [0004] The purpose of the present invention is to provide a good mechanical dressing to solve the defects that the...

Claims

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Application Information

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IPC IPC(8): A61L15/32A61L15/42A61L15/46A61L15/44
CPCA61L15/225A61L15/32A61L15/325A61L15/42A61L15/46A61L15/44A61L2300/252A61L2300/404A61L2300/412C08L89/00A61L26/0033A61L26/0066A61L15/58A61L2300/214A61L2300/216
Inventor 张锐鲁建国赵鲁苹宫宇
Owner ZHENDE MEDICAL CO LTD
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