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Composition for reducing blood pressure and/or for reducing neutral fats

A neutral fat and composition technology, applied in the directions of drug combination, application, food science, etc., can solve problems such as less side effects, and achieve the effect of less side effects, high safety, and reducing neutral fat.

Pending Publication Date: 2020-12-04
MORINAGA MILK IND CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, there are people who strongly desire less side effects, high safety, and more excellent active ingredients for lowering blood pressure and / or for reducing neutral fat

Method used

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  • Composition for reducing blood pressure and/or for reducing neutral fats
  • Composition for reducing blood pressure and/or for reducing neutral fats
  • Composition for reducing blood pressure and/or for reducing neutral fats

Examples

Experimental program
Comparison scheme
Effect test

no. 2 approach

[0245] The fermented food and drink of the present invention uses casein hydrolyzate and Since indigestible dextrin is used as a raw material, the bitter taste of these peptides, the unpleasant smell, and the unpleasant smell of gum are easily produced. In this case, using (1) sucralose, and / or, (2) one or more monosaccharides or rare sugars selected from the group consisting of fructose, allulose, and allulose is suitable. By using such sucralose, rare sugar, etc., it is possible to mask the unpleasant smell of the fermented food and drink of the present invention without impairing the unique aroma of the fermented food and drink as much as possible. Flavor of indigestible dextrin fermented food and drink. Moreover, by using (3) lactulose and lactoligosaccharide in the fermented food-drinks of this invention, these unpleasant smell etc. can be suppressed, and milk flavor can be improved more favorably.

[0246] 〔1-3-2-4. Functionally labeled food and drink〕

[0247] In ad...

Embodiment

[0489] Hereinafter, the present invention will be described in more detail based on examples, test examples, and the like. In addition, the Example, test example, etc. demonstrated below are an example which shows the representative Example of this invention, and are not intended to interpret the scope of this invention narrowly by this.

[0490] [Tests related to the blood pressure lowering effect and / or neutral fat reducing effect of the present invention]

manufacture example 1

[0492] Add 900 mg of water to 100 mg of commercially available casein (manufactured by New Zealand Dairy Company) to make it fully dispersed, add sodium hydroxide to adjust the pH of the solution to 7.0, completely dissolve the casein, and prepare casein with a concentration of about 10%. protein solution.

[0493] The casein aqueous solution was heat-sterilized at 85° C. for 10 minutes, the temperature was adjusted to 50° C., and the pH was adjusted to 9.0 by adding sodium hydroxide. Then, 2 mg of trypsin (manufactured by Amano Enzyme Inc.) and 4 mg of protease A (Amano Enzyme Inc.) were added. Enzyme Inc.), the hydrolysis reaction was started. After 8 hours, heat at 80°C for 6 minutes to inactivate the enzyme and stop the enzyme reaction, and cool to 10°C.

[0494] The hydrolyzate was subjected to ultrafiltration with an ultrafiltration membrane having a molecular weight cutoff of 1000 (manufactured by Nihon Pall Ltd.), concentrated, and then freeze-dried to obtain 85 mg of...

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Abstract

Provided is a composition for reducing blood pressure and / or reducing neutral fats that has few side effects and is very safe. The composition for reducing blood pressure and / or for reducing neutral fats comprises a casein hydrolysate and digestion-resistant dextrin. Ideally, the casein hydrolysate contains a peptide comprising Met-Lys-Pro. Ideally, the casein hydrolysate contains a peptide comprising Met-Lys-Pro and the composition comprises 5,000-100,000 parts by mass of digestion-resistant dextrin with respect to 1 part by mass of said peptide.

Description

technical field [0001] The present invention relates to compositions and the like for lowering blood pressure and / or for reducing neutral fat. Background technique [0002] Lifestyle disease is the main factor hindering healthy and long life, so the country or medical institutions recommend lifestyle disease patients or their reserves to improve their living habits. There are various types of lifestyle diseases, and examples include hypertension, dyslipidemia, and diabetes. [0003] In hypertension, since high blood pressure exerts strong pressure on blood vessel walls, blood vessels are damaged, aging phenomena are accelerated, and it also has adverse effects on the whole body (especially the kidneys, brain, retina of the eyes, etc.). In addition, in dyslipidemia, LDL cholesterol and neutral fat (triglyceride) in the blood damage the inside of blood vessels and gradually lead to arteriosclerosis. Each of these hypertension and dyslipidemia does not have characteristic sym...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/17A23L2/00A23L33/18A23L33/21A61K31/718A61P3/06A61P9/12C07K5/062
CPCA23L33/18A61P9/12A23L33/21A61K31/718A61P3/06A61K38/018A23L33/125A23L33/19A61K9/143A61K2300/00A23C9/12
Inventor 多田明日翔田中美顺越智大介堀笼美也子柳泽咏子
Owner MORINAGA MILK IND CO LTD