A kind of varenicline tartrate tablet and preparation method thereof

A technology for varenicline tartrate and tablets, which is applied in the directions of pill delivery, pharmaceutical formulations, and non-active ingredients medical preparations, etc., can solve the problems of reduced dissolution rate of tablets, unsuitable for long-term use, cumbersome process, etc. High dissolution, low friability and good fluidity
CN112057431BActive Publication Date: 2022-07-15JIANGSU HANSOH PHARMA CO LTD +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
JIANGSU HANSOH PHARMA CO LTD
Publication Date
2022-07-15

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Abstract

The invention provides a varenicline tartrate tablet and a preparation method thereof. The weight percentage of sorbitol and microcrystalline cellulose in the composition is 5:1 to 10:1, and includes a disintegrating agent, a binder agents and lubricants. The preparation process of the product is simple, easy to operate, good in reproducibility, and suitable for large-scale industrial production. Moreover, the varenicline tartrate composition prepared by the present invention not only does not need to control the particle size, but also has small friability, good fluidity, high dissolution rate, good stability and low probability of adverse reactions.
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Description

technical field

[0001] The invention belongs to the field of pharmaceutical preparations, in particular to a varenicline tartrate tablet and a preparation method thereof. Background technique

[0002] Varenicline can specifically bind to acetylcholine receptors to regulate cholinergic function. Accordingly, the compounds are useful in the treatment of various diseases or conditions including, but not limited to, inflammatory bowel disease, irritable bowel syndrome, spastic dystonia, chronic pain, acute pain, vasoconstriction, anxiety, panic disorder, depression , Bipolar Disorder, Autism, Sleep Disorder, Jet Lag, Amyotrophic Lateral Sclerosis (ALS), Cognitive Impairment, Hypertension, Hyperphagia, Anorexia, Obesity, Cardiac Arrhythmia, Hyperacidity , ulcers, pheochromocytoma, chemical dependence and addiction (eg, dependence on or addiction to nicotine (and / or tobacco products), alcohol, benzodiazepines, barbiturates, opioids, or cocaine), Headache, migraine, stroke, traum...

Claims

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