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Surfactant-free urine analysis quality control liquid

A surfactant and urine analysis technology, which is applied in the field of urine analysis quality control fluid without surfactant, can solve the problems of reduced expression of substance reactions, variability of protein substances, and increased dosage of ingredients, etc., to achieve The effect of extending shelf life, long storage time and low production cost

Pending Publication Date: 2020-12-22
成都恩普瑞生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the urinalysis quality control solution on the market needs to use surfactants to stabilize the system, but in this system, the activity of protein substances in it will be reduced, the expression will be weakened, and the sensitivity will be reduced;
[0004] Moreover, due to the use of surfactants for adjustment, the reaction expression of substances in the existing quality control liquid system is reduced, so in order to enhance the reaction effect of the product, it is necessary to increase the amount of ingredients, resulting in increased costs
[0005] In addition, because the existing quality control solution uses surfactants to stabilize the system, after long-term storage, some organic components that are difficult to dissolve in water are prone to isomerization, and protein substances are easily denatured, which is not conducive to long-term storage.

Method used

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  • Surfactant-free urine analysis quality control liquid
  • Surfactant-free urine analysis quality control liquid
  • Surfactant-free urine analysis quality control liquid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A urinalysis quality control solution free of surfactants, comprising:

[0028]

[0029]

[0030] In this embodiment, what the buffer solution adopts is Tris-HCl buffer solution with a pH value of 7; what the hydrolase adopts is lipase; what the bilirubin substitute adopts is direct bilirubin; what the urobilinogen substitute adopts It is sodium pyrrolidine dithioformate; the ketone body substitute is sodium acetoacetate; the sugar is glucose.

[0031] That is, the urinalysis quality control solution not containing surfactant of the present implementation comprises:

[0032] 20mmol / L of Tris-HCl buffer solution with a pH of 7;

[0033] Lipase 0.2g / L;

[0034] BSA 200mg / L;

[0035] Bovine hemoglobin 0.2g / L;

[0036] Sodium nitrite 100mg / L;

[0037] Calcium nitrate 200mg / L;

[0038] Direct bilirubin 100mg / L;

[0039] Sodium pyrrolidine dithioformate 0.2g / L;

[0040] Acetyl acetate sodium salt 0.2g / L;

[0041] Creatinine 200mg / L;

[0042] Glucose 2g / L.

Embodiment 2

[0044] Compared with Example 1, the urinalysis quality control solution that does not contain surfactant in this implementation includes:

[0045] Tris-HCl buffer solution 5mmol / L with pH 7;

[0046] Lipase 0.1g / L;

[0047] BSA 50mg / L;

[0048] Bovine hemoglobin 0.1g / L;

[0049] Sodium nitrite 20mg / L;

[0050] Calcium nitrate 50mg / L;

[0051] Direct bilirubin 20mg / L;

[0052] Sodium pyrrolidine dithioformate 0.1g / L;

[0053] Acetyl acetate sodium salt 0.1g / L;

[0054] Creatinine 50mg / L;

[0055] Glucose 1g / L.

Embodiment 3

[0057] Compared with Example 1, the urinalysis quality control solution that does not contain surfactant in this implementation includes:

[0058] 50mmol / L of Tris-HCl buffer solution with a pH of 7;

[0059] Lipase 1g / L;

[0060] BSA 500mg / L;

[0061] Bovine hemoglobin 1g / L;

[0062] Sodium nitrite 200mg / L;

[0063] Calcium nitrate 500mg / L;

[0064] Direct bilirubin 200mg / L;

[0065] Sodium pyrrolidine dithioformate 1g / L;

[0066] Acetyl acetate sodium salt 1g / L;

[0067] Creatinine 500mg / L;

[0068] Glucose 10g / L.

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Abstract

The embodiment of the invention discloses a surfactant-free urine analysis quality control liquid. The surfactant-free urine analysis quality control liquid comprises 5-50 mmol / L of a buffer solution,0.1-1 g / L of hydrolase, 50-500 mg / L of BSA, 0.1-1 g / L of bovine hemoglobin, 20-200 mg / L of sodium nitrite, 50-500 mg / L of calcium ions, 20-200 mg / L of a bilirubin substitute, 0.1-1 g / L of a urogen substitute, 0.1-1 g / L of ketone substitute, 50-500 mg / L of creatinine and 1-10g / L of sugar. The surfactant-free urine analysis quality control liquid disclosed by the embodiment of the invention does not need a surfactant or a protein protective agent, so that the real-time stability is improved, the toxicity is lower, the sensitivity is higher, and the detection result is more accurate; moreover, the production cost is lower, and the storage time is longer; and the surfactant-free urine analysis quality control liquid provided by the embodiment of the invention is a greener, more environment-friendly and more excellent urine analysis quality control liquid solution.

Description

technical field [0001] The invention relates to the technical field of urine analysis and detection quality control, in particular to a urine analysis quality control solution without surfactant. Background technique [0002] In today's society, people pay more and more attention to the field of physical health. Among them, urinalysis is used as a routine physical examination method to detect kidney and other diseases, and the quality control of urinalysis is even more important. [0003] At present, the urinalysis quality control solution on the market needs to use surfactants to stabilize the system, but in this system, the activity of protein substances in it will be reduced, the expression will be weakened, and the sensitivity will be reduced; [0004] Moreover, due to the use of surfactants for adjustment, the reaction expressivity of substances in the existing quality control liquid system is reduced. Therefore, in order to enhance the reaction effect of the product, i...

Claims

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Application Information

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IPC IPC(8): C12Q1/44C12Q1/40C12Q1/37C12Q1/34
CPCC12Q1/44C12Q1/40C12Q1/37C12Q1/34G01N2333/92G01N2333/916G01N2333/976G01N2333/928
Inventor 杨阳杨莉韦莉华
Owner 成都恩普瑞生物工程有限公司
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