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New application of colchicine

A technology for new uses of colchicine, applied in the field of new uses of colchicine, can solve the problems of non-division of cells, inability to form two daughter cells, doubling of chromosomes, etc., achieving good patient compliance, reducing treatment costs, and reducing medical insurance. The effect of paying pressure

Pending Publication Date: 2020-12-25
徐明中 +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In such mitosis, although the chromosomes split longitudinally, the cell does not divide and cannot form two daughter cells, thus doubling the chromosomes
Since American scholar Blakeslee (A.F.Blakeslee) succeeded in doubling the chromosome number of Datura and other plants with colchicine in 1937, colchicine has been widely used in cytology, genetics research and plant breeding. , consult foreign literature ( Biber J, Murer H, et al.:Role of microtubules in the rapid upregulation of rat renal proximal tubular Na-Pi cotransport following dietary P restriction.J Clin Invest 1997,99:1302–1312), found that colchicine can inhibit renal tubular Expression of epithelial sodium-phosphorus cotransporter, which has not been used in the treatment of hyperphosphatemia

Method used

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  • New application of colchicine

Examples

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Effect test

Embodiment 1

[0014] Patient 1, age 47, uremia patient, dialysis for 5 years, blood phosphorus level before treatment was 2.28mmol / l, administered colchicine 0.5mg bid, 0.5 hours before meal, blood phosphorus level after treatment was 1.89mmol / l.

Embodiment 2

[0016] Patient 2, age 25, uremia patient, dialysis for 6 years, blood phosphorus level before treatment was 2.8mmol / l, administered colchicine 0.5mgbid, 0.5 hours before meal, blood phosphorus level after treatment was 2.3mmol / l.

Embodiment 3

[0018] Patient 3, age 53, uremia patient, dialysis for 9 years, blood phosphorus level before treatment was 2.4mmol / l, 0.5mgbid colchicine was administered 0.5 hours before meal, blood phosphorus level after treatment was 2.17mmol / l.

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Abstract

The invention discloses a new application of colchicine, an application of the colchicine as a medicine for treating hyperphosphatemia which is caused due to chronic renal insufficiency and uremia, and an application of the colchicine as a medicine for inhibiting phosphorus absorption of intestinal tracts and renal tubules. Compared with an existing phosphorus-reducing medicine, the colchicine islow in price and beneficial to reduction of expenditure of patients, extremely few clinical side effects of a small dosage of the colchicine are caused, and patient compliance is good.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a new application of colchicine. Background technique [0002] Patients with chronic renal insufficiency and uremia have hyperphosphatemia. The current therapeutic drugs combine phosphorus in food to reduce the absorption of phosphorus in the intestines to reduce the blood scale level of patients. They are called phosphorus binders. Traditional Currently available drugs for reducing blood phosphorus are expensive and have mediocre effects, so there is an urgent need for an affordable drug for reducing blood phosphorus. [0003] Colchicine, an alkaloid, was originally extracted from the lily plant colchicine, hence the name, also known as colchicine. Pure colchicine is in the form of yellow needle-like crystals with a melting point of 157°C. Soluble in water, ethanol and chloroform. Bitter, poisonous. Colchicine can inhibit mitosis, destroy the spindle, and make chromosomes s...

Claims

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Application Information

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IPC IPC(8): A61K31/165A61P7/08A61P3/00A61P13/12A61P29/00
CPCA61K31/165A61P7/08A61P3/00A61P13/12A61P29/00
Inventor 徐明中
Owner 徐明中
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