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Application of breast milk and active components including human whey protein and human lactoferrin thereof as hepatitis B virus inhibitors

A technology of human lactoferrin and whey protein, which is applied in the field of hepatitis B virus inhibitors, can solve the problems of low breastfeeding rate and achieve the effect of improving breastfeeding rate, good safety and good curative effect

Pending Publication Date: 2020-12-25
NANJING DRUM TOWER HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Misunderstandings and prejudices such as these lead to low breastfeeding rates among children of HBV-infected mothers in my country

Method used

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  • Application of breast milk and active components including human whey protein and human lactoferrin thereof as hepatitis B virus inhibitors
  • Application of breast milk and active components including human whey protein and human lactoferrin thereof as hepatitis B virus inhibitors
  • Application of breast milk and active components including human whey protein and human lactoferrin thereof as hepatitis B virus inhibitors

Examples

Experimental program
Comparison scheme
Effect test

experiment example

[0033] Experimental example: the effect of human whey protein on inhibiting HBV infection

[0034] Detection principle:

[0035] In the HBV infection system used in the present invention, HBV is derived from the culture supernatant of HepG2.2.15 cells. HepG2.2.15 is a good in vitro research tool for the development of new anti-HBV drugs. The cell line is formed by transfecting the recipient cell HepG2 with two recombinant plasmids of the whole HBV-DNA gene linked head to tail. It can be asexually reproduced in vitro and can secrete HBsAg, HBeAg and complete virus into the culture supernatant stably for a long time. Dane particles, which can also produce a large number of replication intermediates, are a good model for in vitro screening of anti-HBV drugs widely used in practice. The method of concentrating HBV is as follows: collect the supernatant of HepG2.2.15 cultured for seven days, add sterilized polyethylene glycol-8000 (PEG-8000) solution to make the final concentrati...

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Abstract

The invention provides an application of breast milk and active components including human whey protein and human lactoferrin thereof as hepatitis B virus inhibitors. According to the invention, the effective inhibition components including the human whey protein and the human lactoferrin aiming at HBV are screened, identified and provided from the breast milk and can be used as the HBV inhibitorsfor preventing and / or treating diseases caused by the HBV. The human whey protein and human lactoferrin components can be specifically combined with HBsAg to inhibit HBV infected cells and intracellular replication, are the effective HBV inhibitors, and are high in safety, so that the human whey protein and human lactoferrin components can be applied to prevention and / or treatment of the diseasescaused by the HBV.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the use of breast milk and its active components human whey protein and human lactoferrin as hepatitis B virus inhibitors. Background technique [0002] Hepatitis B virus (HBV) infection is the main cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma in my country. HBV can be transmitted through unclean injection and blood products, mother-to-child infection, close contact and sexual contact. Mother-to-child transmission of HBV, that is, hepatitis B surface antigen (HBsAg) positive (ie, HBV infected) mothers transmit the virus to their children, is an important cause of chronic HBV infection in my country. Since the 1980s, my country has gradually promoted the immune prevention of HBV infection (HBV vaccine combined with HBV immunoglobulin), and HBV mother-to-child transmission has been significantly reduced. However, there are still challenges in how to reasonably ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/17A61K38/40A61P31/20A61P1/16A61P35/00
CPCA61K38/40A61K38/1709A61P31/20A61P1/16A61P35/00
Inventor 周乙华骆予倩向宽辉胡娅莉庄辉
Owner NANJING DRUM TOWER HOSPITAL