Use of nightshade or nightshade extract for increasing susceptibility to antibiotics or antineoplastic drugs

A technology of anti-tumor drugs and extracts, applied in the field of medicine, to achieve the effect of increasing sensitivity, reducing dosage, and making full use of

Active Publication Date: 2022-02-25
XIANGYA HOSPITAL CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Solanum nigrum and its extracts have the effect of interfering with the abnormal DNA methylation and histone modification of bacteria and tumor cells, but there is no mechanism based on the regulation of epigenetics, solanum nigrum is used in combination with antibiotics and anti-tumor drugs to treat bacteria and tumor drug resistance

Method used

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  • Use of nightshade or nightshade extract for increasing susceptibility to antibiotics or antineoplastic drugs
  • Use of nightshade or nightshade extract for increasing susceptibility to antibiotics or antineoplastic drugs
  • Use of nightshade or nightshade extract for increasing susceptibility to antibiotics or antineoplastic drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A pharmaceutical composition for increasing the susceptibility of antibiotics, the pharmaceutical composition comprising antibiotics and nightshade, the mass ratio of antibiotics and nightshade in the pharmaceutical composition, and the types of antibiotics are shown in Table 1.

[0027] The preparation method of the present embodiment pharmaceutical composition is:

[0028] (1) Grind the nightshade fruit into a coarse powder, add 6 times the amount of water, stir and extract at 20°C for 0.5-4 hours, extract twice, and use high performance liquid chromatography to monitor the content of solanine in the extract during the extraction process content, to ensure that the content of solanine in the obtained freeze-dried powder is 3-6mg / g, stop the extraction when reaching the corresponding content, combine the extracts, filter, centrifuge, put the centrifugate into a freeze-drying box, freeze-dry, extract and grind into powder , obtain the fine powder of crossing 200 mesh si...

Embodiment 2～7、 comparative example 1～2

[0032] The pharmaceutical compositions of Examples 2-7 include antibiotics and Solanum nigrum, and the mass ratio of antibiotics and Solanum nigrum in the pharmaceutical composition, and the types of antibiotics are shown in Table 1. Comparative Example 1 did not contain black nightshade, and Comparative Example 2 did not contain antibiotics.

[0033] The preparation method of the pharmaceutical composition of Examples 2-7 and Comparative Examples 1-2 is the same as that of Example 1.

[0034] Table 1

[0035]

[0036]

Embodiment 8～14、 comparative example 3～4

[0038] The pharmaceutical compositions of Examples 8-14 include anti-tumor biological drugs and Solanum nigrum, and the mass ratios of anti-tumor biological drugs and Solanum nigrum in the pharmaceutical compositions, and the types of anti-tumor biological drugs are shown in Table 2. Comparative Example 3 did not contain black nightshade, and Comparative Example 4 did not contain anti-tumor biological drugs.

[0039] The preparation method of the pharmaceutical composition of Examples 8-14 and Comparative Examples 3-4 is the same as that of Example 1.

[0040] Table 2

[0041] anti-tumor biopharmaceuticals Mass ratio of Solanum solanum to antitumor biological drug Example 8 Nivolumab 50:1 Example 9 Nivolumab 20:1 Example 10 Nivolumab 10:1 Example 11 Nivolumab 5:1 Example 12 Nivolumab 1:1 Example 13 Bevacizumab 10:1 Example 14 Adalimumab 10:1 Comparative example 3 Nivolumab Does not contain nightshad...

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Abstract

The invention relates to the application of nightshade or nightshade extract in increasing the sensitivity of antibiotics or antitumor drugs, and belongs to the technical field of medicine. The present invention finds that nightshade or Solanum nigrum extract is used in combination with antibiotics or antitumor drugs, which can increase the sensitivity of antibiotics or antitumor drugs, reduce dosage, improve the safety of drug use and prolong the treatment time. The pharmaceutical composition of the present invention is based on the mechanism that nightshade or nightshade extract can interfere with DNA abnormal methylation and histone modification, and can be used for treating antibiotics or tumor drug resistance. The present invention provides a new solution for the resistance of existing antibiotics or antineoplastic drugs, fully utilizes and prolongs the life cycle of existing drugs, and is more in line with the current level of the pharmaceutical industry and the status quo of pharmaceutical investment from the principle of medical economics.

Description

technical field [0001] The invention relates to the application of nightshade or nightshade extract in increasing the sensitivity of antibiotics or antitumor drugs, and belongs to the technical field of medicine. Background technique [0002] Antibiotics and antineoplastic drugs are the main means of treating infectious diseases and tumors respectively. However, due to the evolution mechanism of bacteria and tumors themselves, as well as the long-term use of large doses of antibiotics and antineoplastic drugs, the problem of bacterial and tumor drug resistance is intensifying. [0003] Natural medicines are rich in biologically active substances. A large number of studies have shown that scientific compatibility of traditional Chinese medicine and western medicine can synergize, increase sensitivity, reduce dosage, and reduce toxic and side effects. Combining traditional Chinese medicine with antibiotics and antineoplastic drugs may play unique advantages in improving bacter...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/81A61K45/06A61K39/395A61P31/04A61P35/00A61K31/5377
CPCA61K36/81A61K45/06A61K39/39558A61K31/5377A61P31/04A61P35/00A61K2300/00
Inventor 李岱李湘平付喆魏康竞付四海
Owner XIANGYA HOSPITAL CENT SOUTH UNIV
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