Biological specimen preserving fluid and system containing same and integrating specimen collection and preservation functions

Abstract

The invention belongs to the technical field of medical biology. A biological specimen preserving fluid comprises 10-500 g / L of silk fibroin and 10-500 mmol / L of trehalose, a collecting structure is provided with a silk membrane, the silk fibroin is composed of a large hydrophobic structural domain and a small hydrophilic structural domain to form a nano-scale crystallization structural domain, the crystal transition temperature is high, and protein active molecules fixed on the crystallization structural domain have good temperature stability. Trehalose is a polyhydroxy hydrophilic compound,molecules in the biological specimen and silk fibroin form hydrogen bonds, inherent stability and mechanical strength are achieved for temperature and humidity changes, it is avoided that effective components in the biological specimen are affected by temperature or degradation effects of enzymes, and the problem that a biological specimen needs to be stored in a cold chain in the transportation process is solved. The invention provides a system containing the preserving fluid and integrating specimen collection and preservation functions, and the system can be used for collecting and preserving blood, oral and nasal mucous membrane fluid, sputum, urine, cerebrospinal fluid, lung lavage fluid and the like.

Description

technical field [0001] The invention belongs to the technical field of medical biology, and in particular relates to a biological specimen preservation solution and a system including the specimen collection and preservation functions integrated therein. Background technique [0002] Bacteria, viruses, microorganisms or various proteins, enzymes, lipids, and sugars contained in biological samples can be used as markers for health screening, monitoring and diagnosis. The stability of the markers in biological samples It determines the accuracy of clinical test results, so it can be seen that the stable preservation of biological specimens is very important. [0003] At present, the preservation of biological specimens is mainly through pre-treatment and refrigeration to prevent the degradation of biological specimens. However, in actual operation, frozen biological specimens need to be repeatedly frozen and thawed. This process will lead to a decrease in thermodynamic free en...

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Problems solved by technology

[0004] Therefore, the technical problem to be solved by the present invention is to overcome the defects that the existing biological specimens are difficult to store stably for a long time and easily cause cross-contamination, so as to provide a preservation solution that can store biological specimens stably for a long time and facilitate the timely collection and detection of biological specimens by medical staff. An integrated system of specimen collection and preservation that effectively prevents cross-contamination

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