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Composition for intestinal tract preparation

A composition and application technology, applied in the direction of drug combination, active ingredients of artificially synthesized polymer materials, medical preparations containing active ingredients, etc., can solve the problem of unsatisfactory bowel cleansing effect, reduce patient compliance, and increase colonoscopy medical treatment Burden and other issues

Active Publication Date: 2021-02-05
唐传生物科技(厦门)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Polyethylene glycol (PEG) is a commonly used bowel preparation drug. PEG has the advantages of simple method and low price. However, oral administration of PEG has adverse reactions such as nausea, vomiting, and abdominal distension. In addition, PEG also has poor bowel cleansing effect. Ideal, it can’t achieve the effect of colonoscopy observation, causing patients to repeat the intestinal preparation process, which not only affects the patient’s psychology of intestinal preparation before colonoscopy, but also greatly reduces the patient’s compliance, and is far from achieving the preparation effect stated in the drug instructions. It will increase the medical burden of colonoscopy

Method used

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  • Composition for intestinal tract preparation
  • Composition for intestinal tract preparation
  • Composition for intestinal tract preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0111] The present embodiment prepares a kind of emulsion, and described emulsion prescription is as shown in table 1:

[0112] Table 1 The formulation composition of the emulsion

[0113]

[0114] Preparation:

[0115] The emulsion preparation method of the embodiment of the present invention 1 is the same, and the steps are as follows:

[0116] (1) Mix the components of the water phase in the prescribed amount, heat to 70°C, stir and mix to obtain the water-based A phase;

[0117] (2) Mix the components of the oil phase and the components of the emulsifier in the prescribed amount, heat to 70°C, stir and mix to obtain the oily phase B;

[0118] (3) Slowly inject the water-based phase A into the oily phase B under stirring, continue to stir evenly for 6 minutes, then use a homogenizer to homogenize at 12,000 rpm for 5 minutes, and fully emulsify to obtain a water-in-oil emulsion.

[0119] Particle size performance determination:

[0120] The average particle size of th...

Embodiment 2

[0122] The present embodiment is the same as Example 1, and the difference is that the prescription of the emulsion is as shown in Table 2:

[0123] Table 2 The formulation composition of the emulsion

[0124]

Embodiment 3

[0126] The present embodiment is the same as embodiment 1, and the difference is that the prescription of the emulsion is as shown in table 3:

[0127] Table 3 The formulation composition of the emulsion

[0128]

[0129]

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PUM

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Abstract

The invention relates to a composition for intestinal tract preparation. Specifically, the invention provides a composition which comprises PEG and arabinose. The composition provided by the inventionhas excellent gut purging effect and patient compliance.

Description

technical field [0001] The invention relates to the field of medicines, in particular to a composition for bowel preparation. Background technique [0002] With the development of endoscopic technology, colonoscopy has been widely used clinically and has become one of the main means of diagnosis and treatment of various intestinal diseases. Colonoscopy is affected by bowel preparation to some extent. It is extremely important to make adequate bowel preparation before surgery to improve the image quality of colonoscopy to improve the detection rate of colonic diseases. [0003] Bowel preparation refers to a method such as oral cathartics or enemas to remove feces from the intestinal tract, reduce the number of intestinal bacteria and postoperative complications. Bowel preparation is widely used before bowel surgery, colonoscopy, enteroscopy, capsule endoscopy diagnosis and treatment, and imaging examination, and is the key to the success of colonoscopy and bowel surgery. An...

Claims

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Application Information

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IPC IPC(8): A61K31/77A61K31/7004A61K9/107A61K47/44A61P1/10A61P1/08A61P1/00
CPCA61K31/77A61K31/7004A61K9/107A61K47/44A61P1/10A61P1/08A61P1/00A61K2300/00
Inventor 石国良林卫军王羽娟郭志坚蔡许斌
Owner 唐传生物科技(厦门)有限公司
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