Pharmaceutical composition consisting of calcium channel blocker and serotonin reuptake inhibitor
A technology of calcium channel blocker and composition, applied in the field of pharmacy, can solve the problems of not paying attention to the mental and psychological health of hypertensive patients, the effect of antihypertensive treatment, lack of sufficient cognition, etc., so as to relieve depression or anxiety. Effect
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Examples
Embodiment 1
[0030] Embodiment 1. preparation amlodipine 5mg / paroxetine 20mg sheet (1000 sheet quantity)
[0031]
[0032]
[0033] Preparation method: pass the raw materials and auxiliary materials of the prescription amount through an 80-mesh sieve, and set aside. Take 5g of amlodipine and 20g of paroxetine and mix them uniformly according to the method of equal increase, add lactose, microcrystalline cellulose, sodium carboxymethyl starch and low-substituted hydroxypropyl cellulose respectively according to the prescription amount, and mix evenly according to the method of equal increase , use 5% povidone K30-95% ethanol solution to make soft material, granulate with 20 mesh sieve, dry at 40°C for about 2 hours, granulate with 18 mesh sieve, control the water content of the granules to 2-3%, dry the granules Weigh, add magnesium stearate in a ratio of 1.0%, and the semi-finished product is detected, and the tablet weight is calculated according to the content of the total mixed pa...
Embodiment 2
[0034] Embodiment 2. preparation felodipine 5mg / paroxetine 20mg sheet (1000 sheet quantity)
[0035]
[0036] Preparation method: pass the raw materials and auxiliary materials of the prescription amount through an 80-mesh sieve, and set aside. Take 5g of felodipine and 20g of paroxetine and mix them uniformly according to the method of equal increase, add lactose, microcrystalline cellulose, sodium carboxymethyl starch and croscarmellose sodium respectively according to the prescription amount, and mix them evenly according to the method of equal increase. Mix, then mix with glyceryl behenate evenly, test the semi-finished product, measure the content, and directly compress it into 1000 tablets with a tablet machine.
Embodiment 3
[0037] Embodiment 3. preparation lacidipine 4mg / paroxetine 20mg sheet (1000 sheet quantity)
[0038]
[0039] Preparation method: pass the raw materials and auxiliary materials of the prescription amount through an 80-mesh sieve, and set aside. Take 4g of lacidipine and 20g of paroxetine and mix them uniformly according to the method of equal increase, add lactose, microcrystalline cellulose, sodium carboxymethyl starch and croscarmellose sodium respectively according to the prescription amount, Mix, then mix with glyceryl behenate evenly, test the semi-finished product, measure the content, and directly compress it into 1000 tablets with a tablet machine.
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Description
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Application Information
- IPC
- A61K45/06; A61K31/4525; A61K31/4422; A61P9/12; A61P25/22; A61P25/24
- CPC
- A61K45/06; A61K31/4525; A61K31/4422; A61P9/12; A61P25/22; A61P25/24; A61K2300/00
- Inventors
- 耿庆山; 张磊