Micro-needle mask containing active peptide and preparation method thereof

A technology of microneedle and facial mask, which is applied in the field of skin care products, can solve the problems that active ingredients cannot fully penetrate the skin, microneedles remain in the body, and the efficiency of essence is low, so as to achieve sufficient and effective care, simple use method, simple and convenient operation Effect

Inactive Publication Date: 2021-02-23
上海可米日化股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The traditional microneedle transdermal drug delivery generally goes through two steps: first, use microneedle equipment, such as a microneedle roller, to stimulate the face, and then apply a nursing mask for care. The ingredients cannot fully penetrate the skin, so that the skin absorbs the essence inefficiently and cannot perform skin care efficiently; and if the microneedle device is accidentally broken during use, the microneedle will remain in the body, causing damage to the skin. damage

Method used

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Examples

Experimental program
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Effect test

preparation example Construction

[0037] The preparation method of above-mentioned microneedle facial mask, comprises the steps:

[0038] The first step is to prepare the microneedle stock solution, the specific process is as follows:

[0039] 1. Take an appropriate amount of hyaluronic acid or hyaluronate, add an appropriate amount of water, and stir to fully hydrolyze the hyaluronic acid or hyaluronate to obtain a hyaluronic acid or hyaluronate solution;

[0040] 2. Take an appropriate amount of active peptide, water-soluble fatty alcohol, and hardening film material, add water, and stir to fully mix the raw materials to obtain the active peptide mixture;

[0041] 3. Heat the active peptide mixture in (2), and when the temperature rises to 30-50°C, add the active peptide mixture into the hyaluronic acid or hyaluronate solution in (1) During the process, stirring is carried out so that the active peptide mixture is fully mixed with the hyaluronic acid or hyaluronate solution to obtain the auxiliary stock sol...

specific Embodiment approach 1

[0050] Specific implementation mode 1: Preparation of blue copper peptide microneedle mask

[0051] Required raw materials: 70% hyaluronic acid, 20% trehalose, 5% ethylhexylglycerin, 3% blue copper peptide, and the balance is water.

[0052] The detailed preparation process is as follows:

[0053] The first step is to prepare the microneedle stock solution, the specific process is as follows:

[0054] 1. Take 70% hyaluronic acid, add an appropriate amount of water, and stir to fully hydrolyze the hyaluronic acid to obtain a hyaluronic acid solution;

[0055] 2. Add 3% blue copper peptide, 5% ethylhexylglycerin, and 20% trehalose to water, and stir to fully mix the raw materials to obtain a blue copper peptide mixture;

[0056] 3. Heat the blue copper peptide mixture in (2), and when the temperature rises to 30°C, add the blue copper peptide mixture into the hyaluronic acid solution in (1) and stir. Fully mix the blue copper peptide mixture with the hyaluronic acid solution ...

specific Embodiment approach 2

[0064] Specific embodiment two: preparation of palmitoyl pentapeptide microneedle mask

[0065] Required raw materials: 60% hyaluronic acid, 33% trehalose, 10% ethylhexylglycerin, 2% palmitoyl pentapeptide, and the balance is water;

[0066] The detailed preparation process is as follows:

[0067] The first step is to prepare the microneedle stock solution, the specific process is as follows:

[0068] 1. Take 60% hyaluronic acid, add an appropriate amount of water, and stir to fully hydrolyze the hyaluronic acid to obtain a hyaluronic acid solution;

[0069] 2. Take 2% of palmitoyl pentapeptide, 10% of ethylhexylglycerin, and 33% of trehalose, add water, stir, and mix all raw materials fully to obtain palmitoyl pentapeptide mixed solution;

[0070] 3. Heat the palmitoyl pentapeptide mixture in (2), and when the temperature rises to 30°C, add the palmitoyl pentapeptide mixture into the hyaluronic acid solution in (1), and stir. Fully mix the palmitoyl pentapeptide mixed solu...

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Abstract

The invention discloses a micro-needle mask containing active peptide. The micro-needle mask comprises a mask substrate, micro-needles and an essence layer; the microneedles are arranged on the mask substrate; the essence is arranged in the microneedles; the mask is characterized in that the microneedles are formed by processing a plurality of components, and the mask comprises the components, byweight, 60%-92% of hyaluronic acid or hyaluronate, 5%-35% of a hardening material, 1%-15% of water-soluble fatty alcohol, 0.5%-5% of active peptide, and the balance of water; the microneedles are uniformly distributed on the mask substrate, and the number of the microneedles per square centimeter is 180-250; and the lengths of the microneedles are 100-300 microns. The mask is a micro-needle mask which is simple to operate, safe, reliable, efficient in whitening, wrinkle-removing, quick to dissolve and capable of being quickly absorbed into a human body.

Description

technical field [0001] The invention relates to the field of skin care products, in particular to a microneedle mask containing active peptides and a preparation method thereof. Background technique [0002] Peptides are small molecular proteins, which are connected by amino acids with a certain sequence through amide bonds. Two amino acids are called dipeptides, three amino acids are called tripeptides, and so on; in the skin care process, win Peptides play an important role, such as cell proliferation, cell migration, pigment formation, and protein synthesis and regulation; with further understanding of the microstructure and care mechanism of the skin, a variety of peptides used in skin care can promote collagen production. Skin care functions such as generation, anti-free radical oxidation, anti-inflammatory repair. [0003] Studies have shown that the skin care effect of active peptides is mainly through two ways: one is to block the transmission process of neurotransm...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/02A61K8/34A61K8/64A61K8/73A61Q19/00A61Q19/02A61M37/00
CPCA61K8/0212A61K8/345A61K8/64A61K8/735A61K2800/91A61M37/0015A61M2037/0023A61Q19/00A61Q19/02
Inventor 陈云生王淑荣孙西洋王照斌令狐梦玲芦俊霞
Owner 上海可米日化股份有限公司
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