Method for extracting shikimic acid and quinic acid from ginkgo biloba extract adsorptioncolumn-discharging water

An extract, shikimic acid technology, applied in the field of natural plant extraction, can solve the problems of unsuitability for industrial production, high requirements for preparation equipment, complex process routes, etc., achieve wide industrial application prospects, good purification effect, and high purity

Active Publication Date: 2021-02-23
CHENGUANG BIOTECH GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The process route is complicated and requires high preparation equipment, so the equipment input cost is high and the output is low, so it is not suitable for industrial production

Method used

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  • Method for extracting shikimic acid and quinic acid from ginkgo biloba extract adsorptioncolumn-discharging water

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] A method for extracting shikimic acid and quinic acid from ginkgo biloba extract adsorbed column water, comprising the steps of:

[0041] 1) Ginkgo biloba extract is adsorbed and the column water is passed through a 5nm ceramic membrane. The filtration temperature is 47°C and the filtration pressure is 0.21MPa. Yield 96.38%, quinic acid yield 95.46%;

[0042] 2) The ceramic membrane filtrate is passed through a 500-700 molecular weight nanofiltration membrane, the filtration temperature is 36 ° C, the filtration pressure is 0.56 MPa, the retentate is washed 3 times, and the washing liquid and the permeate are combined to obtain the nanofiltration membrane filtrate, wherein shikimic acid Yield 92.38%, quinic acid yield 93.46%;

[0043]3) The nanofiltration membrane filtrate is concentrated to obtain a concentrated solution with a solid content of 60%, the concentration temperature is 82°C, and the vacuum degree is -0.079Mpa;

[0044] 4) Under the condition of 45°C, use...

Embodiment 2

[0050] A method for extracting shikimic acid and quinic acid from ginkgo biloba extract adsorbed column water, comprising the steps of:

[0051] 1) Ginkgo biloba extract is adsorbed and the column water is passed through a 25nm ceramic membrane. The filtration temperature is 52°C and the filtration pressure is 0.29MPa. %, quinic acid yield 97.95%;

[0052] 2) The ceramic membrane filtrate is passed through a 500-700 molecular weight nanofiltration membrane, the filtration temperature is 40 ° C, the filtration pressure is 0.64 MPa, the retentate is washed 3 times, and the water washing liquid and the permeate are combined to obtain the nanofiltration membrane filtrate. The yield of shikimic acid 95.67%, quinic acid yield 97.16%;

[0053] 3) The nanofiltration membrane filtrate is concentrated to obtain a concentrated solution with a solid content of 75%, the concentration temperature is 79°C, and the vacuum degree is -0.070Mpa;

[0054] 4) Under the condition of 55°C, use 93%...

Embodiment 3

[0059] A method for extracting shikimic acid and quinic acid from ginkgo biloba extract adsorbed column water, comprising the steps of:

[0060] 1) Ginkgo biloba extract is adsorbed and the column water is passed through a 50nm ceramic membrane. The filtration temperature is maintained at 55°C and the filtration pressure is 0.40MPa. Yield 99.57%, quinic acid yield 99.95%;

[0061] 2) The ceramic membrane filtrate is passed through a 500-700 molecular weight nanofiltration membrane, the filtration temperature is maintained at 45 ° C, the filtration pressure is 0.68 MPa, the retentate is washed 3 times, and the washing liquid and the permeate are combined to obtain the nanofiltration membrane filtrate, shikimic acid Yield 99.37%, quinic acid yield 98.16%;

[0062] 3) The nanofiltration membrane filtrate is concentrated to a solid content of 85%, the concentration temperature is 85°C, and the vacuum degree is -0.080Mpa;

[0063] 4) At 60°C, use 95% ethanol to carry out alcohol ...

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Abstract

The invention discloses a method for extracting shikimic acid and quinic acid from ginkgo biloba extract adsorption column-discharging water, wherein the method comprises the steps: taking ginkgo biloba extract adsorption column-discharging water concentrated solution with solid content of 60-90%, and carrying out alcohol precipitation on the concentrated solution by using 90-95% short carbon chain alcohol, wherein the ratio of the volume of short carbon chain alcohols to the mass of the concentrated solution is (4-5):1; filtering to obtain a shikimic acid filtrate and a quinic acid crude extract; drying and concentrating the shikimic acid filtrate to obtain a shikimic acid crude extract; dissolving the shikimic acid crude extract by using 85-95% ethanol, crystallizing, and drying to obtain shikimic acid with the purity of more than or equal to 98%; and dissolving the quinic acid crude extract by using 85-95% methanol, crystallizing, and drying to obtain quinic acid with the purity ofmore than or equal to 98%. Quinuclidic acid and shikimic acid in the ginkgo biloba extract preparation waste liquid can be extracted at the same time, operation is easy and convenient, the purification effect is good, and the method is suitable for industrial production and good in practicability.

Description

technical field [0001] The invention belongs to the technical field of natural plant extraction, and in particular relates to a method for extracting shikimic acid and quinic acid from column water absorbed by ginkgo biloba extract. Background technique [0002] Quinic acid (Quinic acid) and shikimic acid (Shikimic acid), are the unique alicyclic organic acids of higher plants, both have multiple chiral centers, and are important materials in three-dimensional organic synthesis. They are used as chiral raw materials to synthesize drugs, It is widely used in the preparation of new polymeric materials. For example, by affecting the metabolism of arachidonic acid, shikimic acid can inhibit platelet aggregation, inhibit arterial and venous thrombosis and cerebral thrombosis, and has anti-inflammatory and analgesic effects, and can also be used as an intermediate of antiviral and anticancer drugs. Shikimic acid is mostly used as a pharmaceutical intermediate, which is irritating...

Claims

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Application Information

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IPC IPC(8): C07C51/42C07C51/43C07C62/32C07C62/04
CPCC07C51/42C07C51/43C07C2601/14C07C2601/16C07C62/32C07C62/04Y02P20/54
Inventor安晓东李佳高伟连运河吕兴娜
OwnerCHENGUANG BIOTECH GRP CO LTD