Oxymatrine and tributyrin composite microcapsules as well as preparation method and application thereof

A technology of tributyrin and oxymatrine, applied in application, microcapsule, digestive system, etc., can solve problems such as harm to human health, lack of weaned piglets, antibiotic residues, etc., and achieve the effect of reducing diarrhea rate

Active Publication Date: 2021-04-06
NANJING AGRICULTURAL UNIVERSITY
View PDF10 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, my country's aquaculture industry still mainly uses antibiotics to reduce the incidence of weaned piglet diarrhea, so it will cause antibiotic residues in meat p

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Oxymatrine and tributyrin composite microcapsules as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026]Preparation method of oxidative alkali-tributylglyceride composite microcapsules A includes the following steps:

[0027]Step 1, prepare the core material: dissolve 1 g of oxidative alcohol in 2 ml of deionized water, then filtered with 0.22 μm filter, then filtered oxide hydrazine solution and liquid tributyate, according to volume ratio 1: 19 Mixed and used high shear emulsifier to emulsify 10 min under 16 000 rpm to obtain a core material. Among them, the mass ratio of oxidative alcoholine and liquid tributyrate is 1: 15.7.

[0028]Step 2, the capsule preparation: Mix the mass ratio of 1: 1 molt dextrin and ocenic succinate sodium starch, add deionized water, stirred in a water bath at 60 ° C to dissolve, to obtain maltodextrin and octene The total concentration of sodium starch sodium starch is 30% aqueous solution as a capsule.

[0029]Step 3, prepare the core sac mixing liquid: according to the core material and the bladder mass ratio of 1: 3, the core material is added to the st...

Embodiment 2

[0032]Preparation method of oxidative alkali-tributylglyceride composite microcapsules B, including the following steps:

[0033]Step 1, the core material is prepared: 1 g of oxidative alcoholine is dissolved with 3 ml of deionized water, and then filtered with 0.22 μm filter, then the filtered oxide aqueous solution and liquid tributyate is 1% by 1: 9 Mixed and used a high shear emulsifier to emulsify 15 min at 13000 rpm to obtain a core. Among them, the mass ratio of oxide incense and liquid tributyate is 1: 8.9.

[0034]Step 2, the capsule materials: gave the mass ratio of 1: 2, maltodextrin and octylene succinate sodium in the ionized water, and stirred in a water bath at 70 ° C to dissolve, to obtain maltodextrin and ocenyl The total concentration of succinate sodium was 20% aqueous solution as a capsule.

[0035]Step 3, prepare the core sac mixing liquid: according to the core material and the bladder mass ratio of 1: 4, in the case of the core material to step 2, the mix is ​​uniform,...

Embodiment 3

[0038]Preparation method of oxidative alkali-tributylglyceride composite microcapsules C included the following steps:

[0039]Step 1, the core material is prepared: 1 g of oxidative alcoholine is dissolved with 4 mL of deionized water, then filtered with 0.22 μm filter, and then filtered, then the hydrate-based alcoholine solution and liquid tributyrate, according to the volume ratio of 1: 4 Mixed and used high shear emulsifier to emulsify 20 min at 10,000 rpm to obtain a core material. Among them, the mass ratio of oxidative alcoholine and liquid tributyrate is 1: 3.6.

[0040]Step 2, the bladder is prepared: gave the mass ratio of 1: 3 maltodextrin and oxyl succinate sodium in the deionized water, and stirred in a water bath at 80 ° C to dissolve, to obtain maltodextrin and ocenyl The total concentration of succinate sodium was aqueous solution of 25% of the aqueous solution to prepare a capsule.

[0041]Step 3, prepare the core sac mixing liquid: according to the core material and the bl...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention provides oxymatrine and tributyrin composite microcapsules as well as a preparation method and application thereof, and belongs to the technical field of medicine preparation. The oxymatrine and tributyrin composite microcapsules comprise a core material and a capsule material; the core material comprises oxymatrine and tributyrin; the capsule material comprises maltodextrin and starch sodium octenylsuccinate. According to the oxymatrine and tributyrin composite microcapsules, the discomfort of the taste of oxymatrine is overcome, and the oxymatrine and tributyrin composite microcapsules which have a synergistic effect in the aspect of reducing the diarrhea rate of weaned pigs and can replace antibiotic products are provided.

Description

Technical field[0001]The present invention belongs to the technical field of drug preparation, and more particularly to oxidative alcoholica and tributyrate composite microcapsules and preparation methods and applications thereof.Background technique[0002]Oxidative alcoholine is the main component of traditional Chinese medicine, with a variety of pharmacological effects, such as antioxidant, anti-inflammatory, antibacterial, antiviral, anti-fibrosis, anti-tumor and neuroprotection. At present, oxidative alkali-based drugs limits its application in breeding due to its shortcomings.[0003]Trilanate is a short chain fatty acid ester, slightly fat aroma. It does not decompose in the gastric juice, slowly released tertiaryric acid and glycerin under the action of intestine lipase, repair small intestinal velvet, inhibits intestinal harmful bacteria, promotes digestive absorption and utilization of nutrients.[0004]At present, my country's farming industry still uses antibiotics to reduce ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A23K50/30A23K50/60A23K20/158A23K20/163A23K20/137A23K40/30A61K9/52A61K47/36A61K47/14A61K31/4375A61P1/12
CPCA23K50/30A23K50/60A23K20/158A23K20/163A23K20/137A23K40/30A61K9/5036A61K31/4375A61K47/14A61P1/12
Inventor 刘斐赵冬单衍可曹金虎金慧琴
Owner NANJING AGRICULTURAL UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap