Whole Liver Bioartificial Liver System
A bioartificial and liver technology, applied in the field of whole liver bioartificial liver system, can solve the problem of low flow rate, achieve the effect of increasing utilization rate, improving perfusion efficiency and avoiding burden
Active Publication Date: 2021-09-17
GUANGDONG UNISUN BIOTECHNOLOGY CO LTD
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Problems solved by technology
However, compared with the natural liver in vivo, the cell-based bioartificial liver still has a certain gap in cell number, three-dimensional structure, and internal and external environment, and the flow rate of the existing bioartificial liver is low, making it difficult for the existing bioartificial liver to meet the needs of patients. need
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[0031] The embodiments of the present application are described in detail below, and examples of the embodiments are illustrated in the drawings, wherein the same or similar reference numerals are indicated by the same or similar elements or elements having the same or similar functions. The following is exemplary, and is intended to explain the present application by referring to the embodiments described with reference to the accompanying drawings.
[0032] See figure 1 This application relates to a whole liver bioartificial liver system, which solves the existing lower circulation rate of bioartificial liver system, it is difficult to meet the needs of patients with severe liver failure problems, are better able to adjust the extracorporeal liver perfusion pressure and flow velocity, and to ensure optimal external environment is in vitro liver, it can exhibit a good cycle purge and replace function.
[0033] Total hepatic bioartificial liver system of the present application in...
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This application provides a whole-hepatic bioartificial liver system, including relatively independent plasma separation and circulation pathways, liver perfusion circulation pathways, plasma separation and reinfusion circulation pathways, and a blood storage tank. The blood storage tank is used to mix patient plasma and extracorporeal liver oxygen. The carrier; the plasma separation circulation pathway includes a blood input pipeline, the first plasma separation pipeline and the blood return pipeline, and the first plasma separation pipeline is connected to the blood storage tank; the liver perfusion circulation pathway includes a biochemical The purification pipeline, the biochemical purification pipeline is connected to the blood storage tank; the plasma separation and return circulation path includes the second plasma separation circulation pipeline and the plasma return pipeline, the input end of the second plasma separation circulation pipeline and the output of the blood storage tank The end is connected, and the slurry return pipeline is connected between the second slurry circulation pipeline and the blood return pipeline. In this application, by setting the blood storage tank, the perfusion pressure, flow rate and flow rate of the extracorporeal liver can be better adjusted, the perfusion efficiency can be improved, and the circulation time can be shortened.
Description
Technical field [0001] The present application relates to the field of biological and medical device, and more particularly, to a whole liver bioartificial liver system. Background technique [0002] Artificial Liver Support System (Artificial Liver Support System, ALSS) is an alternative method of treatment of liver, the liver which is based on a strong self-regeneration capability by mechanical, physical and chemical or biological means of introducing in vitro, removal of harmful substances, essential supplement material, improve the patient environment, temporarily replace part of the function of the liver, liver failure and liver cell repair and regeneration to create conditions in patients, but also for awaiting liver transplant donor to create time. Artificial liver currently divided into two categories, i.e., simple mechanical, physical and chemical apparatus and the non-bioartificial bioartificial liver with a biological cell or whole liver apparatus and the like. [0003...
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IPC IPC(8): A61M1/36
CPCA61M1/3621A61M1/3639A61M1/369
Inventor 高毅薛巍松李阳
Owner GUANGDONG UNISUN BIOTECHNOLOGY CO LTD