Whole-liver bioartificial liver system
A bioartificial and liver technology, applied in the field of whole-liver bioartificial liver system, can solve the problem of low flow rate, and achieve the effect of improving utilization rate, good replacement function, and avoiding burden
Active Publication Date: 2021-04-06
GUANGDONG UNISUN BIOTECHNOLOGY CO LTD
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Problems solved by technology
However, compared with the natural liver in vivo, the cell-based bioartificial liver still has a certain gap in cell number, three-dimensional structure, and internal and external environment, and the flow rate of the existing bioartificial liver is low, making it difficult for the existing bioartificial liver to meet the needs of patients. need
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[0031]The embodiments of the present application are described in detail below, and examples of the embodiments are illustrated in the drawings, wherein the same or similar reference numerals are indicated by the same or similar elements or elements having the same or similar functions. The following is exemplary, and is intended to explain the present application by referring to the embodiments described with reference to the accompanying drawings.
[0032]Seefigure 1 The present application relates to a fullpheldic biological artificial liver system that solves the problem of low cycle flow of the existing biological artificial liver system, difficult to meet the needs of serious patients with hepatic failure, and better regulate the perfusion of the body liver. Pressure and flow rate, flow rate, and ensure that the external liver is in an optimal internal and external environment, allowing it to play a good cycle purification and alternative function.
[0033]The whole liver-type biolo...
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The invention provides a whole-liver bioartificial liver system which comprises a plasma separation and circulation passage, a liver perfusion circulation passage, a plasma separation and return circulation passage and a blood storage tank which are relatively independent, and the blood storage tank is used for mixing plasma of a patient and an in-vitro liver oxygen carrier; the plasma separation and circulation passage comprises a blood input pipeline, a first plasma separation pipeline and a blood return pipeline, and the first plasma separation pipeline is connected with the blood storage tank; the liver perfusion circulation path comprises a biochemical purification pipeline provided with a whole liver perfusion assembly, and the biochemical purification pipeline is connected with the blood storage tank; the plasma separation and return circulation passage comprises a second plasma separation circulation pipeline and a plasma return pipeline, the input end of the second plasma separation circulation pipeline is connected with the output end of the blood storage tank, and the plasma return pipeline is connected between the second plasma separation circulation pipeline and the blood return pipeline. By arranging the blood storage tank, the perfusion pressure, flow and flow velocity of the in-vitro liver can be better adjusted, the perfusion efficiency is improved, and the circulation time is shortened.
Description
Technical field[0001]The present application relates to the field of biological fields and the field of medical devices, in particular to a whole liver-type biological artificial liver system.Background technique[0002]Artificial Liver Support System, AlSS is a liver replacement treatment method, which is based on the liver has strong self-regenerative repair capability. By introducing a mechanical, physicochemical or biological device, remove harmful substances, supplementing human body necessary Substances, improve the internal environment, temporarily replacing part of the liver, to repair the regeneration and regeneration of hepatocytes in patients with liver failure, and also create time for liver transplantation donor. At present, artificial liver is mainly divided into two major categories, namely, non-biological artificial liver, which is simply used, and contains biological artificial liver containing cell or whole liver.[0003]Among them, biometric artificial liver is an art...
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Login to View More IPC IPC(8): A61M1/36
CPCA61M1/3621A61M1/3639A61M1/369
Inventor 高毅薛巍松李阳
Owner GUANGDONG UNISUN BIOTECHNOLOGY CO LTD