Genotyping method and device, electronic equipment and storage medium
A genotyping method and typing technology, applied in sequence analysis, bioinformatics, instruments, etc., can solve the problems of low efficiency of sequence typing, improve the efficiency of comparison and genotyping, reduce processing capacity, and improve Effect of genotyping efficiency
Active Publication Date: 2021-04-09
CHANGSHA DUXACT BIOTECH CO LTD +1
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Problems solved by technology
[0003] Embodiments of the present invention provide a genotyping method, device, electronic equipment, and storage medium to solve the problem of comparing the gene sequencing sequence with the gene sequence in the gene bank one by one in the prior art, due to the gene sequence in the gene bank The large number leads to the problem of low typing efficiency of gene sequencing sequences
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[0025] In order to make the technical problems, technical solutions and advantages to be solved by the present invention clearer, the following will describe in detail with reference to the drawings and specific embodiments. In the following description, specific details, such as specific configurations and components, are provided only to assist in a comprehensive understanding of the embodiments of the present invention. Accordingly, those of ordinary skill in the art should recognize that various changes and modifications of the embodiments described herein can be made without departing from the scope and spirit of the invention. Also, descriptions of well-known functions and constructions are omitted for clarity and conciseness.
[0026] Unless otherwise defined, the technical terms or scientific terms used in the present invention shall have the usual meanings understood by those skilled in the art to which the present invention belongs. "First", "second" and similar wor...
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The embodiment of the invention provides a genotyping method and device, electronic equipment and a storage medium. The genotyping method comprises the steps: obtaining a to-be-typed sequence, a benchmark reference sequence in a preset gene pool and a first difference result set, and enabling the preset gene pool to comprise a plurality of candidate reference sequences, wherein the first difference result set comprises a plurality of first difference results corresponding to the candidate reference sequences respectively, and the first difference results are used for representing differences between the corresponding candidate reference sequences and the benchmark reference sequences; obtaining a second difference result between the to-be-typed sequence and the benchmark reference sequence; determining a target reference sequence from the plurality of candidate reference sequences, wherein the target reference sequence is a candidate reference sequence meeting a first preset condition between the corresponding first difference result and second difference; and determining a typing result of the to-be-typed sequence according to the target reference sequence. According to the embodiment of the invention, the data processing amount can be effectively reduced, and the comparison and genotyping efficiency is improved.
Description
technical field [0001] The invention relates to the technical field of gene detection, in particular to a genotyping method, device, electronic equipment and storage medium. Background technique [0002] As we all know, there are a large number of gene sequences in gene banks such as the International Immunogenetics Information System (IMGT), such as human leukocyte antigen (humanleukocyte antigen, HLA) gene sequences, etc.; Comparing the gene sequences, the typing results of the gene sequencing sequences can be obtained. In the prior art, the gene sequencing sequence is usually compared with the gene sequence in the gene bank one by one. Due to the large number of gene sequences in the gene bank, the typing efficiency of the gene sequencing sequence is low. Contents of the invention [0003] Embodiments of the present invention provide a genotyping method, device, electronic equipment, and storage medium to solve the problem of comparing the gene sequencing sequence with...
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CPCG16B30/10
Inventor 欧阳冬生李晓晖李超鹏谢秀芬谭海灿费云舟
Owner CHANGSHA DUXACT BIOTECH CO LTD