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Biocompatible material

A biocompatibility and base material technology, applied in drug delivery, inorganic non-active ingredients, aerosol delivery, etc., can solve the problems of unable to suppress the pain of stomatitis, cancer patients do not expect therapeutic agents, etc., and achieve scratch resistance excellent effect

Pending Publication Date: 2021-04-13
FUJIFILM CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, these therapeutic agents contain an immunosuppressant steroid as an active ingredient, so they are undesirable therapeutic agents for cancer patients
[0005] In addition, when food is ingested by mouth, the patch attached to the affected area peels off or the ointment or spray applied to the affected area disappears, so the pain of stomatitis cannot be suppressed

Method used

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  • Biocompatible material
  • Biocompatible material
  • Biocompatible material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～30、 comparative example 1～10

[0179]

[0180] The components shown in Table 1 were mixed at the contents shown in Table 1 to prepare biocompatible materials of Examples 1 to 30 and Comparative Examples 1 to 10.

Embodiment 1

[0184] 324 g of sodium alginate (manufactured by Kimica Corporation, Kimika Argin I-S), 36 g of aluminum lactate (manufactured by Musashino Chemical Laboratory, Ltd.), 180 g of xylitol (manufactured by Mitsubishi Corporation Life Sciences Limited., Xylitol P), and carboxyvinyl were uniformly mixed in powder 180 g of a base polymer (manufactured by Lubrizol, CARBOPOL971PNF) was divided into three equal portions.

[0185] 3500 g of liquid paraffin (manufactured by KANEDA Co., Ltd., Hicol M-352) and 3500 g of ointment base Plastibase (manufactured by Taisho Pharmaceutical Co., Ltd.) were evenly mixed, and wrapped with a nylon mesh (manufactured by NBC Meshtec Inc., N-NO. 230T) was filtered. 1080 g of the obtained mixture was charged into a Hibis Dispermix 3D-5 type (manufactured by PRIMIX Corporation), while stirring at 20° C. and a setting of 5 rpm in a planetary mixer (without using a homodisperser) (afterwards, in the same stirring Stir continuously under the conditions), whi...

Embodiment 31

[0287] [Example 31: Confirmation of Stomatitis Protective Effect Based on Stomatitis Model Mice (Part 1)]

[0288] Animal experiments using stomatitis model mice were conducted for the purpose of confirming the stomatitis-protecting function of the biocompatible material of the present invention. The stomatitis model mouse described here refers to a mouse artificially produced with stomatitis, and it is known that such mice cannot take in sufficient food due to pain, resulting in weight loss or starvation (reference: "Ito Toxicity Pathology" Edited by Michito Takahashi and Akiharu Fukushima, Maruzen Publishing (Published on July 30, 2010) (ISBN 978-4-621-08642-1C3047), 6. Toxic pathology of target organs, 6.4. Oral cavity, tongue , Pharynx, P195 "6.4.5 Effects of Disorders").

[0289] Next, the degree of stomatitis was changed, and the protective effect against stomatitis was confirmed by the number of survivors and changes in body weight, respectively.

[0290] 6-week-old m...

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Abstract

The present invention provides a biocompatible material from which a gel having excellent retention ability and scratch resistance can be formed. The biocompatible material of the present invention comprises: an alginate having a weight-average molecular weight of 1,000,000 or higher; an aluminum compound; a carboxyvinyl polymer; and an oil-based material, wherein the biocompatible material does not substantially comprise water.

Description

technical field [0001] The present invention relates to a biocompatible material. Background technique [0002] In cancer patients, cancer treatment can affect the oral mucosa and predispose to stomatitis. For example, in anticancer drug therapy, administration of a drug that easily causes stomatitis, and in radiation therapy for head and neck cancer (cancer ranging from the head to the neck), directly irradiating radiation to the oral mucosa will inevitably cause stomatitis. The pain of stomatitis is so severe that food cannot be taken by mouth. [0003] As a symptomatic treatment for stomatitis, there are patches that are directly attached to the affected area (for example, Aphthaseal (R) 25 μg, manufactured by Taisho Toyama Pharmaceutical Co., Ltd.; active ingredient triamcinolone acetonide), ointment applied to the affected area (for example, Dexaltin oral ointment, manufactured by Nippon Kayaku Co., Ltd; active ingredient dexamethasone), and spray Spray on the affect...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/36A61K9/06A61K9/70A61K47/02A61K47/12A61K47/26A61K47/32
CPCA61K47/32A61K47/02A61K47/26A61K47/36A61K9/06A61K9/006A61K47/44A61K9/5161A61K47/24
Inventor 富川晴贵高久浩二千叶幸介细川隆史
Owner FUJIFILM CORP