Synthesis method of aminoethanethiol

Abstract

The invention provides a synthesis method of a taurine intermediate aminoethanethiol. According to the method, epithioethane and an ammonia compound are subjected to an addition reaction under the catalysis of a modified supported metal catalyst to obtain aminoethanethiol. According to the method, the problem that the epithioethane is easy to self-polymerize after ring opening is solved, the yield is improved, and the production cost is reduced.

Description

technical field

[0001] The invention belongs to the field of preparation of nutritional chemical intermediates, and in particular relates to a synthesis method of aminoethanethiol. Background technique

[0002] Taurine, also known as 2-aminoethanesulfonic acid, is a sulfur-containing non-protein amino acid. Widely present in tissue cells and abundant in the brain. It has the functions of promoting the growth and development of the nervous system and cell differentiation, preventing cardiovascular diseases, affecting lipid absorption, improving immunity, and maintaining normal reproductive needs; therefore, it is widely used in medical treatment, health care, food, etc., and has a good market prospect.

[0003] As an important intermediate in the synthesis of taurine, aminothiol was discovered and studied in recent years. In 2007, Hu, L.B. et al. reported the use of thioacetic acid as a nucleophile to attack polysubstituted aziridines to generate N-acetyl substituted aminot...