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3D polylactic acid stent for bone tissue engineering and preparation method thereof

A technology of bone tissue engineering and polylactic acid, which is applied in the field of 3D polylactic acid scaffold for bone tissue engineering and its preparation, can solve the problems of low strength and the like

Pending Publication Date: 2021-04-20
WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Therefore, it is necessary to develop a scaffold that can induce cell behavior and promote soft tissue repair. On the one hand, it has good biocompatibility and mechanical strength in application, high bioactivity and antibacter

Method used

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  • 3D polylactic acid stent for bone tissue engineering and preparation method thereof
  • 3D polylactic acid stent for bone tissue engineering and preparation method thereof
  • 3D polylactic acid stent for bone tissue engineering and preparation method thereof

Examples

Experimental program
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Example Embodiment

[0029]Example 1

[0030]The preparation method of the 3D polylactic acid bracket for bone disposable engineering provided in this embodiment is as follows:

[0031]The preparation method of the 3D polylactic acid bracket for bone disposable engineering, including the following steps:

[0032]The design of the S1, 3D printing bracket uses AutoCAD 2013, and the CAD model is saved as a stereoscopic .stl file, imported into the printer software. The polylactic acid filament (a fiber is 20d, the intensity is 3 cn / DTEX, the fracture elongation is 25%, the heat shrinkage rate of 15%) is loaded into the 3D printer (Ultimaker3 printer), heated to 180 ° C, then extruded from the nozzle Out, a layer of layer-by-layer structure is formed, a cylindrical 3D polylactic acid bracket having a diameter of 10 mm and a height of 5 mm is produced. The 3D polylactic acid holder consists of strands having a thickness of 0.4 mm, and the gap length of the strand is 0.4 mm.

[0033]S2, the 3D polylactic acid stent in ...

Example Embodiment

[0037]Example 2

[0038]The preparation method of the 3D polylactic acid bracket for bone disposable engineering provided in this embodiment is as follows:

[0039]The preparation method of the 3D polylactic acid bracket for bone disposable engineering, including the following steps:

[0040]The design of the S1, 3D printing bracket uses AutoCAD 2013, and the CAD model is saved as a stereoscopic .stl file, imported into the printer software. The polylactic acid filament (a fiber is 30d, the strength is 5 cn / DTEX, the elongation at break is 35%, the heat shrinkage ratio is 25%), which is loaded into the 3D printer (Ultimaker3 printer), heated to 200 ° C, then extruded from the nozzle Out, a layer of layer-by-layer structure is formed, and a cylindrical 3D polylactic acid bracket having a diameter of 20 mm and a height of 8 mm is produced. The 3D polylactic acid holder consists of strands having a thickness of 0.6 mm, and the gap length of the strand is 0.6mm, and the structure of the 3D pol...

Example Embodiment

[0045]Example 3

[0046]The preparation method of the 3D polylactic acid bracket for bone disposable engineering provided in this embodiment is as follows:

[0047]The preparation method of the 3D polylactic acid bracket for bone disposable engineering, including the following steps:

[0048]The design of the S1, 3D printing bracket uses AutoCAD 2013, and the CAD model is saved as a stereoscopic .stl file, imported into the printer software. The polylactic acid filament (a fiber is 25d, the strength is 30%, the heat shrinkage is 20%, the heat shrinkage ratio is 20%), which is heated to 190 ° C, then extruded from the nozzle Out, a layer of layer-by-layer structure is formed, and a cylindrical 3D polylactic acid bracket having a diameter of 20 mm and a height of 8 mm is produced. The 3D polylactic acid holder consists of strands having a thickness of 0.6 mm, and the gap length of the strand is 0.6 mm.

[0049]S2, the 3D polylactic acid bracket in step S1 is etched for 8 hours with a 0.2 mol / L ...

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Abstract

The invention belongs to the technical field of biomedical materials, and particularly relates to a 3D polylactic acid stent for bone tissue engineering and a preparation method thereof. The preparation method mainly comprises the following two steps of (1) manufacturing a polylactic acid stent through 3D printing; and (2) modifying and coarsening the surface of the stent and introducing gelatin and mucic acid to the surface of the stent. The 3D polylactic acid stent for bone tissue engineering not only has good biocompatibility and mechanical strength, but also can resist bacteria and inflammation and enhance adhesion and proliferation of cells; and in addition, the 3D polylactic acid stent also shows better characteristics with regards to bone induction, protein adsorption, degradation, biomineralization, drug release, cell friendliness and the like, and has a potential application prospect in the biomedical fields of tissue repair and the like.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a 3D polylactic acid scaffold for bone tissue engineering and a preparation method thereof. Background technique [0002] The increasing incidence of bone-related defects has become a serious concern, bone tissue engineering is a promising alternative to induce regeneration of damaged tissue, and tailored scaffold-mediated regeneration is an emerging field in tissue regeneration. field. Polylactic acid (PLA) is a heat-stable aliphatic polyester derived in monomeric form from sugarcane, corn, sugar beet and cassava. The toughness and ductility of PLA can be improved by adopting strategies such as plasticization and copolymerization. Studies have found that natural PLA or PLA paired with polyethylene glycol (PEG), nano-hydroxyapatite or calcium metaphosphate (CMP) can induce new bone formation. Although synthetic scaffolds have better mechanical strength...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/18A61L27/58A61L27/34A61L27/54
Inventor 黄建祥许杉杉
Owner WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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