Mathematical modeling method for drug sustained release of tea polyphenol drug-loaded microspheres

Abstract

The invention provides a mathematical modeling method for drug sustained release of tea polyphenol drug-loaded microspheres. The mathematical modeling method comprises the following steps: S1, establishing a tea polyphenol standard surface equation; S2, converting the formula to obtain a released drug concentration equation; S3, performing conversion to obtain a release amount equation in the time period T; and S4, dividing the time T into enough equal-length micro time periods to obtain a cumulative release amount equation, a dosing amount equation and an encapsulation rate. According to the mathematical modeling method for drug sustained release of the tea polyphenol drug-loaded microspheres, drug sustained release behaviors of a tea polyphenol drug-loaded sustained and controlled release system are modeled again, and a more accurate calculation model is explored.

Description

technical field [0001] The invention relates to the technical field of drug sustained release modeling, in particular to a mathematical modeling method for drug sustained release of tea polyphenol drug-loaded microspheres. Background technique [0002] In recent years, tea polyphenols have attracted more and more attention in the field of biomedicine due to their outstanding antioxidant properties, antibacterial and antiviral properties, and their inhibitory effects on various tumor cells. However, its easy oxidation, easy absorption in the gastrointestinal tract environment and seldom entering the blood circulation limit its clinical application. This problem can be well solved by embedding tea polyphenols in polymers to make microspheres or nanoparticles with slow and controlled drug release properties. [0003] During the slow-release process of the tea polyphenol drug-loaded slow-release system, tea polyphenols react with oxygen in the air to oxidize and deteriorate, wh...

AI Technical Summary

Problems solved by technology

The first is the way of drug loading. Some drugs are added during production, while some drugs are loaded by adsorption. These two methods will inevitably lead to different sustained release behaviors.

Secondly, the molecular weight of the drug itself makes it have different slow-release curves during the slow-release process. The burst release phenomenon of macromolecules such as proteins is not serious during the release process. The higher the molecular weight, the longer the release time, and even lead to the hydrophobicity of the drug. Improve the problem of reducing the cumulative release rate of the drug; and the drug has a small molecular weight, which is more prone to burst release during the release process, and the overall release time is also shorter

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