Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

High-length-diameter-ratio tricalcium phosphate artificial bone meal bone repair material and preparation method thereof

A tricalcium phosphate, high aspect ratio technology, applied in chemical instruments and methods, phosphorus compounds, inorganic chemistry, etc., to achieve the effects of high yield, mild reaction conditions, and broad clinical application prospects

Pending Publication Date: 2021-05-07
JINZHOU MEDICAL UNIV
View PDF9 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But, the preparation method of the tricalcium phosphate artificial bone powder with high aspect ratio characteristic has not seen any report yet

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • High-length-diameter-ratio tricalcium phosphate artificial bone meal bone repair material and preparation method thereof
  • High-length-diameter-ratio tricalcium phosphate artificial bone meal bone repair material and preparation method thereof
  • High-length-diameter-ratio tricalcium phosphate artificial bone meal bone repair material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] A tricalcium phosphate artificial bone repair material with a high aspect ratio, the artificial bone powder bone repair material is rod-shaped tricalcium phosphate particles, and the surface has a porous structure with interconnected pores; the diameter of the artificial bone powder bone repair material is 35-40nm , with a length of 50-75 μm and an aspect ratio of 1.25×10 3 ~2.14×10 3 .

[0037] The preparation method of the above-mentioned high aspect ratio tricalcium phosphate artificial bone powder bone repair material comprises the following steps:

[0038] S1. First, configure the concentration of 0.3mol / L (NH 4 ) 2 HPO 4 solution and a concentration of 0.2mol / L Ca(NO 3 ) 2 solution;

[0039] Under stirring conditions, 30mL (NH 4 ) 2 HPO 4 The solution was added dropwise to 30ml Ca(NO 3) 2 In the solution, control the feeding time to complete within 30 minutes, and after stirring evenly, configure a mixed solution of calcium salt and phosphate with a Ca...

Embodiment 2

[0048] A high aspect ratio tricalcium phosphate artificial bone repair material, the artificial bone powder bone repair material is rod-shaped tricalcium phosphate particles, and the surface is a porous structure with interconnected pores; the diameter of the artificial bone powder bone repair material is 25-30nm , with a length of 85-95 μm and an aspect ratio of 2.83×10 3 ~3.80×10 3 .

[0049] The preparation method of the above-mentioned high aspect ratio tricalcium phosphate artificial bone powder bone repair material comprises the following steps:

[0050] S1. First, configure NaH with a concentration of 0.3mol / L 2 PO 4 solution and a concentration of 0.2mol / L Ca(NO 3 ) 2 solution;

[0051] Under stirring conditions, 20mL NaH 2 PO 4 The solution was added dropwise to 20ml Ca(NO 3 ) 2 In the solution, control the feeding time to complete within 40 minutes, and after stirring evenly, configure it into a mixed solution of calcium salt and phosphate with a Ca / P molar...

Embodiment 3

[0060] A tricalcium phosphate artificial bone repair material with a high aspect ratio, the artificial bone powder bone repair material is rod-shaped tricalcium phosphate particles, and the surface has a porous structure with interconnected pores; the artificial bone powder bone repair material has a diameter of 30-35nm , with a length of 60-80 μm and an aspect ratio of 1.71×10 3 ~2.67×10 3 .

[0061] The preparation method of the above-mentioned high aspect ratio tricalcium phosphate artificial bone powder bone repair material comprises the following steps:

[0062] S1. First, configure K with a concentration of 0.3mol / L 2 HPO 4 Solution and CaCl with a concentration of 0.2mol / L 2 solution;

[0063] Under stirring conditions, 20mL K 2 HPO 4 The solution was added dropwise to 20ml CaCl at a certain speed 2 In the solution, control the feeding time to complete within 20 minutes, and after stirring evenly, configure a mixed solution of calcium salt and phosphate with a C...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
lengthaaaaaaaaaa
diameteraaaaaaaaaa
Login to View More

Abstract

The invention provides a high-length-diameter-ratio tricalcium phosphate artificial bone meal bone repair material and a preparation method thereof. The artificial bone meal bone repair material is rodlike tricalcium phosphate particles, and the surface of the artificial bone meal bone repair material is of a porous structure with mutually communicated pore channels; the diameter of the artificial bone meal bone repair material is 20-40nm, and the length of the artificial bone meal bone repair material is 50-100[mu]m. The bone repair material is of a rodlike porous structure, and has good plasticity on the basis of having certain mechanical strength, so that the bone repair material can be suitable for repairing various bone injury parts and irregular bone defect parts, and is convenient to use and good in biocompatibility. According to the preparation method, the length and diameter of the bone repair material can be changed by changing the pH of a mixed solution of soluble calcium salt and phosphate, the reaction time and temperature, the calcium / phosphorus molar ratio and other conditions, so the high-aspect-ratio tricalcium phosphate artificial bone meal with different aspect ratios is obtained; the method is mild in reaction condition, simple in preparation process, high in yield, and facilitates the industrial production.

Description

technical field [0001] The invention belongs to the technical field of medical biological materials, and in particular relates to a high aspect ratio tricalcium phosphate artificial bone powder bone repair material and a preparation method thereof. Background technique [0002] Medical bioartificial bone powder is a kind of bone tissue engineering repair material for bone defects. The synthetic bone repair material can largely avoid the defects of biological bone repair materials. Bioartificial bone powder has been gradually applied to actual clinical practice due to its functions of repairing, replacing and promoting new bone regeneration in the body's bone tissue. [0003] The artificial bone powder prepared by tricalcium phosphate can be absorbed and utilized by the body in the physiological environment or excreted through the circulatory system in the body while completing specific functions. After repairing the defective bone with tricalcium phosphate artificial bone p...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32
CPCC01B25/32
Inventor 陈震华梅晰凡张鹏张杰王大昊
Owner JINZHOU MEDICAL UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products