Application of pH-responsive copper-based compound nanomaterial serving as disulfiram carrier in preparation of multi-level selective tumor treatment medicine

A technology of nanomaterials and copper compounds, applied in the field of nanobiomedicine, can solve the problems of low selectivity tumor toxicity and side effects
CN112791193APending Publication Date: 2021-05-14ZHEJIANG UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ZHEJIANG UNIV OF TECH
Publication Date
2021-05-14

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Abstract

The invention provides application of a pH-responsive copper-based compound nanomaterial serving as a disulfiram carrier in preparation of a multi-level selective tumor treatment medicine. According to the invention, a functional carrier for performing copper doping (Cu-MSNs) in mesoporous silicon dioxide nanoparticles is prepared by adopting a metal ion doping template method, and a nanodrug delivery system is obtained after disulfiram is loaded. The nanodrug delivery system prepared by the invention can release copper ions and disulfiram after being enriched at a tumor site through an EPR effect, plays a role in both a tissue level and a cell level, improves the effect of chemotherapeutic drugs, reduces systemic toxic and side effects caused by a traditional drug delivery route, and provides a new research direction for in-situ local treatment of tumors.
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Description

technical field

[0001] The invention belongs to the field of nano-biomedicine, and relates to the application of a pH-responsive copper-based compound nanomaterial as a disulfiram carrier in the preparation of multi-level selective therapeutic drugs for tumors. Background technique

[0002] Malignant tumor is a disease that seriously threatens human health. Although significant progress has been made in the diagnosis and treatment of cancer, how to effectively control and overcome malignant tumors has become an urgent problem to be solved. In recent years, chemotherapy using various drugs followed by surgery or radiation therapy is one of the most commonly used cancer treatment strategies in clinical practice. However, the systemic delivery of chemotherapeutic drugs has its limitations, such as severe side effects caused by high dose administration and low selective tumor toxicity. With the development of nanotechnology, nanoparticles with tumor microenvironment responsiven...

Claims

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