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Microjoule amplifier system for three photon microscopy utilizing existing femtosecond lasers

A femtosecond laser and amplifier technology, applied in the field of amplifier systems, can solve the problems of expensive systems and low repetition rates

Pending Publication Date: 2021-05-14
THORLABS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Systems capable of producing these peak power levels are expensive and operate at low repetition rates

Method used

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  • Microjoule amplifier system for three photon microscopy utilizing existing femtosecond lasers
  • Microjoule amplifier system for three photon microscopy utilizing existing femtosecond lasers

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Embodiment Construction

[0012] The description of illustrative embodiments in accordance with the principles of the invention is intended to be read in conjunction with the accompanying drawings, which are considered a part of this entire written description. In describing the various embodiments of the invention disclosed herein, any reference to direction or orientation is for convenience of description only and does not limit the scope of the invention in any way. Words such as "lower", "upper", "horizontal", "vertical", "above", "under", "up", "down", "top" and "bottom" and their derivatives (for example, " Relative terms such as "horizontally," "downwardly," "upwardly," etc.) should be construed to refer to an orientation as subsequently described or as shown in the figure in question. These relative terms are for convenience of description only and do not require the device to be constructed or operated in a particular orientation unless specifically indicated to be so. Terms such as "attached...

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Abstract

Disclosed are ideas to produce an add-on device which turns widely used high repetition rate lasers used for 2-photon microscopy into a light source which can be used for 3-photon microscopy. The add-on encompasses a device to reduce the pulse repetition rate of the high repetition rate (>50 MHz) laser source (laser or OPO) to less than 10 MHz which allows for higher pulse energies while maintaining reasonable average powers. If the high repetition sources operate below 1250 nm the add-on shifts or broadens the seed light to cover 1.3 [Mu]m to 1.8 [Mu]m before amplification. If the high repetition rate source operates at or around 1.3 [Mu]m the add-on only needs to amplify the pulse after downshifting the repetition rate. In another implementation the add-on shifts or broadens the 1.3 [Mu]m light to cover the spectral range out to 1.8 [Mu]m before amplification.

Description

[0001] Cross-References to Related Applications [0002] This application claims the benefit of U.S. Provisional Patent Application No. 62 / 741,930, filed October 5, 2018, the disclosure and full version of which is hereby incorporated by reference. technical field [0003] The present invention relates generally to amplifier systems for multiphoton microscopy, and more particularly to microjoule amplifier systems for three-photon microscopy that utilize existing femtosecond lasers for two-photon microscopy as a seed source . Background technique [0004] In the life sciences, fluorescence microscopy is used to study biological samples such as single cells or to study complex structures such as the brain. Scattering in these samples limits imaging depth. It is generally true that light with longer wavelengths scatters less in tissue, thus allowing it to penetrate deeper into eg the brain. Two-photon (2p) microscopy takes advantage of this and allows imaging down to eg abou...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01S3/07H01S3/107H01S3/108
CPCG02F1/39H01S3/2316H01S3/0057H01S3/0085H01S3/0092G02F2203/54G02F1/392G02F2203/26G02F1/353H01S3/06741G02F1/3532
Inventor P·芬德尔
Owner THORLABS INC
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