A kind of medical radioactive silicon dioxide microsphere and its preparation method and application

A silicon dioxide and radioactive technology, applied in the direction of radioactive carriers, drug combinations, antineoplastic drugs, etc., can solve the problems of large side effects, poor accuracy, and large normal tissue damage, and achieve less radioactive waste, low production costs, and reduce radioactivity radiation effect

Active Publication Date: 2021-11-09
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can realize internal radiation therapy of solid tumors and internal radiation imaging of tumors, and solve the problems of large side effects, poor accuracy, and large damage to normal tissues in the treatment of malignant tumors in the prior art.

Method used

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  • A kind of medical radioactive silicon dioxide microsphere and its preparation method and application
  • A kind of medical radioactive silicon dioxide microsphere and its preparation method and application
  • A kind of medical radioactive silicon dioxide microsphere and its preparation method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0032] Experimental equipment: one ten-thousandth balance (ME204, Mettler-Toledo Shanghai Co., Ltd.); ultrapure water system (DirectQ5, MerckMillipore, USA); constant temperature mixer (YY10, Shanghai Yunyan Instrument Co., Ltd.); radioactivity Activity meter (FJ-391A4, Beijing Nuclear Instrument Factory); gamma radioimmunoassay counter (LB2111, German BERTHOLD company); scanning electron microscope (EVO18, German Carl Zeiss company); SPECT / CT imaging system (Milabs, Hong Kong Merrill Lynch Group) Co., Ltd.); fluorescence microscope (IX73, Japan Olympus Company); commonly used glass and surgical utensils.

[0033] Experimental reagent: silica microspheres (Suzhou Zhiyi Microsphere Technology Co., Ltd.); 177 LuCl 3 Solution (Sichuan Xinke Pharmaceutical Co., Ltd.); potassium hydroxide (Shanghai Aladdin Biochemical Technology Co., Ltd.); phosphoric acid (Shanghai Aladdin Biochemical Technology Co., Ltd.); normal saline (Shanghai Yuanye Biotechnology Co., Ltd.); Ma Lin (Shangha...

Embodiment 3

[0052] Disperse 8mg of silica microspheres in 10mL of pure water, add 1Ci medical radionuclide yttrium chloride [ 90 YCl 3 ] solution, at room temperature, shake in a constant temperature mixer for 10 minutes to prepare a silica microsphere mixture. Under shaking at room temperature, add 0.025 mL of sodium carbonate-sodium hydroxide buffer solution (pH = 12) dropwise to the above silica microsphere mixture, and continue shaking for 30 minutes. After solid-liquid separation, wash with pure water for 4 times, after draining, yttrium carbonate [ 90 YCO 3 ] Medical radioactive silica microspheres.

Embodiment 4

[0054] Disperse 10 mg of silica microspheres in 0.6 mL of pure water, add 0.2 Ci of medical radionuclide yttrium chloride [ 90 YCl 3 ] solution, 0.1Ci medical radionuclide lutetium chloride [ 177 LuCl 3 ] solution, 0.4Ci medical radionuclide strontium chloride [ 89 SrCl 2 ], at room temperature, shake in a constant temperature mixer for 10 minutes to prepare a mixture of silica microspheres. Under shaking at room temperature, add 0.2 mL of potassium chloride-sodium hydroxide (pH = 10) dropwise to the above silica microsphere mixture, continue shaking for 30 minutes, and wash with pure water for 5 times after solid-liquid separation , after draining, the resulting 90 Y, 177 Lu, 89 Hydroxide silica microspheres of various medical radionuclides of Sr.

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Abstract

The invention belongs to the technical field of in vivo tumor radiotherapy and intratumoral radiation imaging, and specifically discloses a medical radioactive silicon dioxide microsphere and its preparation method and application. The radionuclides are adsorbed or deposited in the microspheres, and then further purified to prepare medical radioactive silica microspheres. The adsorption efficiency of silica microspheres to radionuclides is higher than 98%, and the release rate is lower than 1%, which can be used for internal radiation therapy and intratumoral radiation imaging of solid tumors with rich blood vessels such as liver cancer.

Description

technical field [0001] The invention relates to the technical fields of in vivo tumor radiotherapy and intratumoral radiation imaging, in particular to a medical radioactive silicon dioxide microsphere and its preparation method and application. Background technique [0002] Malignant tumors are an important cause of threats to human health. Surgical treatment, chemotherapy, and radiotherapy are the main methods for treating malignant tumors. Surgical therapy is only suitable for early malignant tumors, and requires patients to tolerate surgery. The selectivity of chemotherapeutic drugs in chemotherapy is poor, and side effects of varying degrees often occur while achieving therapeutic results, and the tumor may no longer be sensitive to chemotherapeutic drugs after repeated chemotherapy. External radiation therapy will damage normal tissues and limit the dose of radiation. External radiation therapy also has the disadvantages of poor dose uniformity and accuracy in the tar...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K51/02A61P35/00A61K103/00A61K103/32A61K101/00
CPCA61K51/02A61P35/00
Inventor 王广林高明远吴曼冉张晓璐
Owner SUZHOU UNIV
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