Double-network hydrogel wound dressing and preparation method thereof

A wound dressing and hydrogel technology, used in medical science, bandages, etc., can solve the problems of only short-term improvement, performance decline, and no good interaction, so as to promote repair, improve antibacterial and anti-inflammatory Effect

Active Publication Date: 2021-06-01
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

BC hydrogel has a three-dimensional fiber network structure similar to the extracellular matrix of skin tissue, and has good water absorption and moisture permeability, certain hemostatic function and anti-adhesion performance; Invaded pathogenic bacteria and infected wounds have no effect; on the other hand, because the water in the BC hydrogel will overflow when squeezed, the water retention performance is poor, and it cannot effectively provide an excellent moist environment for the wound
BC-CS hydrogel dressing, on the basis of BC hydrogel, added CS with antibacterial effect, BC-CS hydrogel effectively improved the water retention and mechanical strength of BC hydrogel, making it have a certain The bacteriostatic effect is more conducive to wound healing; but because the BC-CS hydrogel prepared in this way, the CS is directly soaked into the BC fiber network, and there is no good interaction between the two, so it can only be shortened. Time improves the related performance of BC, with the overflow of CS, its performance will decrease significantly

Method used

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  • Double-network hydrogel wound dressing and preparation method thereof
  • Double-network hydrogel wound dressing and preparation method thereof
  • Double-network hydrogel wound dressing and preparation method thereof

Examples

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preparation example Construction

[0044] Such as figure 1 Shown, a kind of preparation method of double network hydrogel wound dressing, it may further comprise the steps:

[0045] (1) preparing aldylated Artemisia annua polysaccharide;

[0046] (2) Preparation of double network hydrogels (such as figure 2 shown).

[0047] In some embodiments, the step (1) includes the following steps:

[0048] (11) Dissolving Artemisia annua polysaccharide in distilled water and stirring to obtain solution A;

[0049] (12) Add absolute ethanol to solution A and stir to obtain solution B;

[0050] (13) After adding sodium periodate in solution B to avoid light and oxidize, solution C is obtained;

[0051] (14) After adding ethylene glycol in solution C and stirring to react, solution D is obtained;

[0052] (15) Add ethanol to solution D, stir, and obtain solution E after standing;

[0053] (16) Suction filter the solution E and dry the filter residue to obtain the aldylated Artemisia annua polysaccharide.

[0054] In s...

Embodiment 1

[0076] 1. Preparation of bacterial cellulose hydrogel (BC hydrogel):

[0077] (1) Cut the bacterial cellulose membrane into a membrane with a size of 2cm*2cm, put it into boiling ultrapure water and boil for 10 minutes to obtain the bacterial cellulose hydrogel.

[0078] (2) Put the bacterial cellulose hydrogel into a container filled with ultrapure water, and sterilize it under high temperature and high pressure for 30 minutes to obtain a sterile bacterial cellulose hydrogel.

[0079] 2. Preparation of bacterial cellulose-chitosan hydrogel (BC-CS hydrogel):

[0080] (1) Cut the bacterial cellulose membrane into a membrane with a size of 2cm*2cm, put it into boiling ultrapure water and boil for 10 minutes to obtain the bacterial cellulose hydrogel.

[0081] (2) 150 mg of carboxymethyl chitosan was dissolved in 30 ml of PBS buffer solution, and the solution was sterilized by filtering through a filter membrane with a pore size of 0.22 μm to obtain a sterile carboxymethyl chito...

Embodiment 2

[0090] Three kinds of hydrogels that embodiment 1 obtains are characterized:

[0091] 1. SEM: After dehydrating the hydrogel gradient, carry out critical point drying, and then perform SEM electron microscope scanning (such as image 3 shown).

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Abstract

The invention discloses a dual-network hydrogel wound dressing and a preparation method thereof, and the preparation method comprises the following steps: (1) preparing polysaccharides from Artemisia annua L.. and (2) preparing the double-network hydrogel. The invention aims to provide the preparation method of the double-network hydrogel wound dressing which is formed by taking bacterial cellulose as a first-layer network and taking oxidized polysaccharides from Artemisia annua L. and carboxymethyl chitosan as a second-layer network. According to the double-network hydrogel wound dressing prepared by the method, the anti-oxidation performance and the repair promoting performance of the wound dressing can be improved, and meanwhile, the mechanical property of the hydrogel is enhanced and the water locking and retaining capacity of the hydrogel is improved by forming the double-network hydrogel.

Description

technical field [0001] The invention relates to the technical field of polymer materials, in particular to a double network hydrogel wound dressing and a preparation method thereof. Background technique [0002] For the repair of skin damage, there are currently two main products: dry dressing and wet dressing. The early dry wound healing theory believed that wound healing needs to be promoted by atmospheric oxygen in a dry environment. Based on this theory, early wound care mostly used gauze made of cotton, hemp and other materials; but later studies showed that epidermal wounds Oxygen cannot be obtained from the atmosphere, and because gauze cannot isolate the wound from the outside world, it is easy to cause bacterial invasion; in addition, during the process of using gauze to care for the wound, the wound will adhere to the gauze, and the newly grown granulation tissue will penetrate into the wound during the wound healing process. into the gap of the gauze; when changi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L1/02C08L5/08C08L5/00A61L26/00
CPCC08J3/075A61L26/008A61L26/0023C08J2301/02C08J2405/08C08J2405/00
Inventor 樊渝江王启光汪婉
Owner SICHUAN UNIV
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