Double-network hydrogel wound dressing and preparation method thereof

Abstract

The invention discloses a dual-network hydrogel wound dressing and a preparation method thereof, and the preparation method comprises the following steps: (1) preparing polysaccharides from Artemisia annua L.. and (2) preparing the double-network hydrogel. The invention aims to provide the preparation method of the double-network hydrogel wound dressing which is formed by taking bacterial cellulose as a first-layer network and taking oxidized polysaccharides from Artemisia annua L. and carboxymethyl chitosan as a second-layer network. According to the double-network hydrogel wound dressing prepared by the method, the anti-oxidation performance and the repair promoting performance of the wound dressing can be improved, and meanwhile, the mechanical property of the hydrogel is enhanced and the water locking and retaining capacity of the hydrogel is improved by forming the double-network hydrogel.

Description

technical field [0001] The invention relates to the technical field of polymer materials, in particular to a double network hydrogel wound dressing and a preparation method thereof. Background technique [0002] For the repair of skin damage, there are currently two main products: dry dressing and wet dressing. The early dry wound healing theory believed that wound healing needs to be promoted by atmospheric oxygen in a dry environment. Based on this theory, early wound care mostly used gauze made of cotton, hemp and other materials; but later studies showed that epidermal wounds Oxygen cannot be obtained from the atmosphere, and because gauze cannot isolate the wound from the outside world, it is easy to cause bacterial invasion; in addition, during the process of using gauze to care for the wound, the wound will adhere to the gauze, and the newly grown granulation tissue will penetrate into the wound during the wound healing process. into the gap of the gauze; when changi...

AI Technical Summary

Problems solved by technology

BC hydrogel has a three-dimensional fiber network structure similar to the extracellular matrix of skin tissue, and has good water absorption and moisture permeability, certain hemostatic function and anti-adhesion performance; Invaded pathogenic bacteria and infected wounds have no effect; on the other hand, because the water in the BC hydrogel will overflow when squeezed, the water retention performance is poor, and it cannot effectively provide an excellent moist environment for the wound

BC-CS hydrogel dressing, on the basis of BC hydrogel, added CS with antibacterial effect, BC-CS hydrogel effectively improved the water retention and mechanical strength of BC hydrogel, making it have a certain The bacteriostatic effect is more conducive to wound healing; but because the BC-CS hydrogel prepared in this way, the CS is directly soaked into the BC fiber network, and there is no good interaction between the two, so it can only be shortened. Time improves the related performance of BC, with the overflow of CS, its performance will decrease significantly

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