An automated system for isolating circulating tumor cells from blood samples

Abstract

The present invention provides an automatic system for separating circulating tumor cells from blood samples, which includes a sample preparation work area, a separation work area, an inspection work area and a general control area that controls and connects the above work areas, and is characterized in that: sample preparation The work area includes automatic sample preparation equipment and automatic sample injection equipment; the separation work area includes red blood cell separation equipment, microfluidic chip equipment, and sample incubation equipment; the inspection work area includes sample analysis equipment; each work area is connected to each other through a connecting device, The connection device is composed of several multi-directional transmission devices; the general control area includes the main console, which controls and connects each work area and the connection device; the present invention can integrate each originally independent instrument and device into one through a special transmission device. In this system, in the process of sample processing and analysis, it is no longer necessary to rely on manpower to transfer samples and operate instruments, avoiding the influence of various adverse factors that may arise in manpower operations.

Description

technical field [0001] The invention belongs to the field of biology and medicine, relates to medical biological testing equipment, in particular to an automatic system for separating circulating tumor cells from blood samples. Background technique [0002] Cancer is currently a major cause of human death. According to statistics from the World Health Organization (WTO), cancer has caused more than 8.8 million deaths in 2015 alone; what people generally refer to as cancer is a general term for all malignant tumors. Generally refers to malignant tumors originating from epithelial tissue; common cancer types include lung cancer, liver cancer, colorectal cancer, gastric cancer, and breast cancer. [0003] Cancer usually originates from normal cells that have become cancerous; under the interaction of the human body's own genetic factors and three carcinogens, such as physical, chemical and biological, the normal cells of the human body become cancerous, begin to abnormally prol...

AI Technical Summary

Problems solved by technology

[0009] Since various CTC separation techniques have their own advantages and disadvantages, the currently commonly used separation and detection techniques usually use a combination of multiple techniques to improve detection sensitivity and obtain undamaged and active CTCs for subsequent research and diagnosis; From the sample to the separation and enrichment, and the subsequent detection links, there are many kinds of instruments used, which often require long-term operation by the user. Each detection takes tens of minutes or even several hours, and the operation process is cumbersome and complicated; due to manual operation It is easy to produce unstable operation errors, which will easily have an adverse effect on the test results. Therefore, an automated system that can integrate various testing instruments is needed at present.

Images