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A kind of medical silver-loaded gauze and preparation method thereof

A gauze and silver-loaded technology, which is applied in the fields of plant fiber, fiber treatment, textiles and papermaking, can solve problems such as damage, and achieve the effects of high safety performance, good dispersibility, and simple operation

Active Publication Date: 2022-07-26
长沙海润生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, nano-silver can not only cause direct damage to the cell membrane through the silver ions released from its surface, but also play a role in the cell. It has clear antibacterial and cytotoxicity, and is not suitable for wounds.

Method used

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  • A kind of medical silver-loaded gauze and preparation method thereof
  • A kind of medical silver-loaded gauze and preparation method thereof
  • A kind of medical silver-loaded gauze and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] A medical silver-carrying gauze of the present invention is loaded with polyamide complex silver in the degreased gauze; the modified polyamide complex silver is composed of silver ions and modified polyamide (see figure 1 ) is complexed with the amino group of the modified polyamide, and the amino group of the modified polyamide exists only in the interior of its molecular structure.

[0040] The medical silver-carrying gauze of the present embodiment is prepared by the following method:

[0041](1) Polyamide synthesis modification: polycondensation reaction between polyamino monomer (triethylenetetramine) and olefinic acid (acrylic acid); specifically, triethylenetetramine is cooled to 5-10°C in an ice-water bath, and then Slowly add acrylic acid dropwise to it with a funnel, and react at room temperature for 4 hours to form a light yellow intermediate after the addition is completed. ℃ under reduced pressure for 2-4 hours to obtain a polyamino hyperbranched polymer;...

Embodiment 2

[0048] A medical silver-carrying gauze of the present invention is loaded with polyamide complex silver in the degreased gauze; the modified polyamide complex silver is composed of silver ions and modified polyamide (see figure 1 ) is complexed with the amino group of the modified polyamide, and the amino group of the modified polyamide exists only in the interior of its molecular structure.

[0049] The medical silver-loaded gauze of the present embodiment is prepared by the following method:

[0050] (1) Synthesis and modification of polyamide: polycondensation reaction occurs between polyamino monomer (diethylenetriamine) and olefinic acid (methyl acrylate); specifically, diethylenetriamine is cooled to 5-10°C in an ice-water bath , and then slowly add methyl acrylate dropwise to it with a funnel. After the dropwise addition, the reaction is performed at room temperature for 4 hours to generate a light yellow intermediate. The intermediate is placed on a rotary evaporator t...

Embodiment 3

[0057] A medical silver-carrying gauze of the present invention is loaded with polyamide complex silver in the degreased gauze; the modified polyamide complex silver is composed of silver ions and modified polyamide (see figure 1 ) is complexed with the amino group of the modified polyamide, and the amino group of the modified polyamide exists only in the interior of its molecular structure.

[0058] The medical silver-loaded gauze of the present embodiment is prepared by the following method:

[0059] (1) Synthesis and modification of polyamide: polycondensation reaction occurs with polyamino monomer (mixed solution of diethylenetriamine and tetraethylenepentamine) and olefinic acid (methyl acrylate); The 1:1 mixture of ethylene pentamine was cooled to 5-10°C in an ice-water bath, and then methyl methacrylate was slowly added dropwise to it with a funnel. After the dropwise addition, the reaction was performed at room temperature for 4 hours to form a pale yellow intermediate...

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Abstract

The invention discloses a medical silver-carrying gauze. The modified polyamide complex silver is loaded in the gauze; the modified polyamide complex silver is mainly composed of silver ions and the amino group of the modified polyamide complexed. The amino group of an amide exists only in the interior of its molecular structure. The silver ions are wrapped in the modified polyamide, and then tightly combined with the gauze, so that the silver ions can be fixed and released in a small amount, and the release is stable; the release time of silver ions is more than 8 days, and the release is lasting; the antibacterial performance is excellent; It is non-nano-silver, non-irritating, non-sensitizing, non-acute and chronic systemic toxicity, non-genotoxic, and has good biocompatibility. The invention also discloses the preparation method of the medical silver-carrying gauze, which has the advantages of simple operation, low cost, environmental friendliness, high safety performance, and no new impurity elements are introduced.

Description

technical field [0001] The invention belongs to the field of medical materials, in particular to a medical silver-carrying gauze and a preparation method thereof. Background technique [0002] Silver dressing is a dressing change for chronic refractory wounds. The current silver-containing dressings are easy to oxidize due to the characteristics of silver ions themselves, so that the dressings themselves are prone to discoloration and lose the bacteriostatic effect, and the uncontrollable release of silver can easily lead to silver deposition and the bacteriostatic effect is not lasting. [0003] In order to overcome the problems of easy oxidation and uncontrollable release of silver ions, a cationic type closed space network structure polyamide dendrimer polymer-stabilized nano-silver aqueous solution was designed in the prior art, and it was combined with gauze infiltration. However, nanosilver can enter cells in the form of particles through the endocytic pathway and con...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D06M15/59D06M11/00C08G73/02D06M101/06
CPCD06M15/59D06M11/00C08G73/028D06M2101/06
Inventor 何杰熊翰超史丙华姜志华
Owner 长沙海润生物技术有限公司
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