Production and preparation method of calculus bovis factitius-venenum bufonis granule, prepared calculus bovis factitius-venenum bufonis granule and application of calculus bovis factitius-venenum bufonis granule

A technology of granule and bovine toad, which is applied in the directions of non-active ingredient medical preparations, medical preparations containing active ingredients, and pharmaceutical formulas, etc. problems, to improve the efficacy of drugs, improve the dispersion effect, improve the effect of palatability

Inactive Publication Date: 2021-07-02
LUOYANG HUIDE BIO ENG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But its weak point is that the main ingredient in the Niu Toad granule has numb tongue, the borneol has a certain irritation, and the bile acid in the artificial bezoar is bitter. , due to the above-mentioned defects in palatability, Niu Chan granules are sensitive to the taste of pigs, and the therapeutic effect on livestock with picky tastes is affected; and the solubility of toad su and artificial bezoar in water is poor because of the important pharmacologically active ingredients contained in it. It is not soluble in water, so the solution after the venom granule dissolves is turbid, and the prepared high-concentration solution sometimes blocks the pipeline, causing great inconvenience to the drinking water of poultry; it is also not conducive to the absorption of active ingredients of the drug by animals after taking it, thus affecting the product Clinical efficacy

Method used

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  • Production and preparation method of calculus bovis factitius-venenum bufonis granule, prepared calculus bovis factitius-venenum bufonis granule and application of calculus bovis factitius-venenum bufonis granule
  • Production and preparation method of calculus bovis factitius-venenum bufonis granule, prepared calculus bovis factitius-venenum bufonis granule and application of calculus bovis factitius-venenum bufonis granule
  • Production and preparation method of calculus bovis factitius-venenum bufonis granule, prepared calculus bovis factitius-venenum bufonis granule and application of calculus bovis factitius-venenum bufonis granule

Examples

Experimental program
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Effect test

Embodiment 1

[0019] Embodiment 1 Preparation of Niutoad granules of the present invention

[0020] (1) Take by weighing 4g artificial bezoar, 2g toad venom, 2g borneol, 1000g scutellaria baicalensis, 200g licorice for later use;

[0021] (2) Prepare a citric acid buffer solution with a pH of 3.5: 0.1mol / L citric acid solution, take 21.01g of citric acid, add 1000ml of purified water, dissolve, shake well, 0.1mol / L sodium citrate solution, take sodium citrate 29.41g, add 1000ml of purified water, dissolve, shake well, the volume ratio of the two is 15.5:4.5, mix well;

[0022] (3) Add the artificial bezoar and toad venom taken in step (1) into 100 parts by weight of fresh milk and grind evenly, then filter, and the filtrate is for subsequent use;

[0023] (4) Take 7g of phospholipids and 3g of cholesterol, add 50ml of absolute ethanol, stir in a water bath at 70°C to dissolve and disperse the ethanol, add 100ml of citric acid buffer at the same temperature after film formation, stir in a w...

Embodiment 2

[0028] Embodiment 2 The preparation of another bovine toad granule of the present invention

[0029] (1) Take by weighing 4g artificial bezoar, 2g toad venom, 2g borneol, 1000g scutellaria baicalensis, 200g licorice for later use;

[0030](2) Prepare a citric acid buffer solution with a pH of 5.0: 0.1mol / L citric acid solution, take 21.01g of citric acid, add 1000ml of purified water, dissolve, shake well, 0.1mol / L sodium citrate solution, take sodium citrate 29.41g, add 1000ml of purified water, dissolve, shake well, the volume ratio of the two is 8.2:11.8;

[0031] (3) Add the artificial bezoar and toad venom taken in step (1) into 100 parts by weight of fresh milk and grind evenly, then filter, and the filtrate is for subsequent use;

[0032] (4) Take 7g of phospholipids and 3g of cholesterol, add 50ml of absolute ethanol, stir in a water bath at 73°C to dissolve and disperse the ethanol, add 100ml of citric acid buffer at the same temperature after film formation, stir in...

Embodiment 3

[0037] Embodiment 3 The preparation of another bovine toad granule of the present invention

[0038] (1) Take by weighing 4g artificial bezoar, 2g toad venom, 2g borneol, 1000g scutellaria baicalensis, 200g licorice for later use;

[0039] (2) Prepare a citric acid buffer solution with a pH of 6.0: 0.1mol / L citric acid solution, take 21.01g of citric acid, add 1000ml of purified water, dissolve, shake well, 0.1mol / L sodium citrate solution, take sodium citrate 29.41g, add 1000ml of purified water, dissolve, shake well, the volume ratio of the two is 3.8:16.2;

[0040] (3) Add the artificial bezoar and toad venom taken in step (1) into 100 parts by weight of fresh milk and grind evenly, then filter, and the filtrate is for subsequent use;

[0041] (4) Take 7g of phospholipids and 3g of cholesterol, add 50ml of absolute ethanol, stir in a water bath at 75°C to dissolve and disperse the ethanol, add 100ml of citric acid buffer at the same temperature after film formation, stir i...

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Abstract

The invention provides a production and preparation method of a calculus bovis factitius-venenum bufonis granule. According to the preparation method, blank liposome is coated with calculus bovis factitius and venenum bufonis, so the prepared calculus bovis factitius-venenum bufonis granule does not influence the feed intake of pigs at all, and meanwhile, calculus bovis factitius-venenum bufonis granule is beneficial to absorption of active pharmaceutical ingredients after being taken by animals, and curative effect is ensured.

Description

technical field [0001] The invention relates to the technical field of veterinary drug preparations, in particular to a production and preparation method of venomous toad granule, the prepared veterinary toad granule and its application. Background technique [0002] The ingredients of Niu Chan Granules include artificial bezoar, toad venom, borneol, scutellaria baicalensis and licorice. Diseases, etc., mainly used for livestock and poultry viral diseases and respiratory diseases. The main ingredient, toad venom, is the secretion of toad's auricular glands and epidermal glands. It has significant anti-virus, anti-bacterial and anti-inflammatory effects, and enhances the body's immunity. It also has the characteristics of low toxicity, high efficiency, and no residue; it can detoxify and reduce swelling. , strong heart, pain relief, the main active ingredient is aglycone, which is a steroidal compound; artificial bezoar is processed from bovine bile powder, cholic acid, hyod...

Claims

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Application Information

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IPC IPC(8): A61K36/539A61P11/00A61P31/04A61P31/12A61P31/14A61K9/127A61K9/16A61K47/36A61K31/045A61K35/413A61K35/65A61K36/484
CPCA61K35/413A61K35/65A61K31/045A61K36/539A61K36/484A61K9/127A61K9/1623A61K9/1652A61P11/00A61P31/12A61P31/14A61P31/04A61K2236/331A61K2300/00
Inventor 刘飞鸟李冬冬梁立钦雷海昌于利红
Owner LUOYANG HUIDE BIO ENG CO LTD
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