A kit for the treatment of habitual abortion caused by the reduction or absence of blocking antibodies

Abstract

Unexplained habitual abortion is a kind of infertility that is difficult to cure. Insufficient or missing blocking antibody is the main reason for habitual abortion. According to the principle of immunology, the active immunization method of habitual abortion was born. The active immunization method uses the lymphocytes in the peripheral blood of the patient's spouse to stimulate the patient's immune system to trigger the production of blocking antibodies, so that the placenta is protected after pregnancy. A kit for the treatment of habitual abortion caused by insufficient or missing blocking antibodies, which uses the principle of active immunization to treat habitual abortion, and uses the clinical-grade medical reagents and special sterile lymphocyte separation device in the kit, which can be simple, fast and safe Aseptically isolate the lymphocytes in the peripheral blood of the patient's spouse, and then inject them subcutaneously in the patient's upper arm. The concentration of lymphocytes in each injection is 20-30*10 9 / L, inject 3 to 4 Pichu points, 0.25ml per point, once every 3 weeks, 4 times as a course of treatment. After years of clinical research, the success rate of active immunization in the treatment of habitual abortion is 83.72%. If combined with other treatment methods, the success rate of treatment can be further improved.

Description

Technical field [0001] The present invention belongs to the third class of medical technology - immune cell therapy industry. Background [0002] In normal pregnant women, there is an antibody against the spousal lymphocytes, which binds to the antigen on the surface of the placental cells, thereby blocking the immune attack of the maternal T lymphocytes on the placenta, which is called blocking antibody. When for some reason the pregnant woman lacks this blocking antibody, the embryo is attacked by the lymphocytes of the mother, resulting in recurrent miscarriage. At present, in view of this habitual miscarriage caused by the reduction or lack of blocking antibodies, the active immunotherapy is mainly taken from the spouse lymphocytes as antigens, that is, lymphocytes are isolated from the whole blood of the spouse for subcutaneous injection, so that sufficient blocking antibodies are produced in the body. However, in the process of clinical use, the isolation of lymphocytes is ...

AI Technical Summary

Problems solved by technology

However, in the process of clinical use, the separation of lymphocytes is cumbersome, the purity of the cells is not high, the doctor's operation is more complicated, and it is easy to cause pollution, and even cause adverse reactions in patients after injection.

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