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Iron metabolism-related protein marker composition and application thereof for risk prediction of high myopia and auxiliary diagnosis of high myopia

A technology of high myopia and markers, applied in the field of biomedicine, can solve problems such as myopia and affect patients' diopter, and achieve high-sensitivity effects

Active Publication Date: 2022-02-01
TIANJIN EYE HOSPITAL OPTOMETRIC DEPT
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Problems solved by technology

However, no research has revealed the differentially expressed proteins related to corneal cell metabolism and proliferation in different myopic populations, and what kind of corneal morphology or ultrastructural changes will be caused by cell metabolism and proliferation, which will affect the patient's diopter and eventually lead to myopia, especially development of high myopia

Method used

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  • Iron metabolism-related protein marker composition and application thereof for risk prediction of high myopia and auxiliary diagnosis of high myopia
  • Iron metabolism-related protein marker composition and application thereof for risk prediction of high myopia and auxiliary diagnosis of high myopia
  • Iron metabolism-related protein marker composition and application thereof for risk prediction of high myopia and auxiliary diagnosis of high myopia

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Embodiment

[0040] 1. Experimental method

[0041] In this experiment, the corneas removed from patients undergoing femtosecond laser-assisted small incision lenticule extraction (SMILE) in the Eye Hospital Affiliated to Nankai University (Tianjin Eye Hospital) from February 2019 to August 2019 were selected. Stromal tissue, a total of 133 people, 259 eyes, all patients are not accompanied by other ocular and systemic diseases except for myopia diagnosis of different degrees, which will not affect the analysis of corneal protein results. This study was approved by the Ethics Committee of Nankai University.

[0042] All patients were divided into low myopia group (SE>-3.00D) and moderate myopia group (-6.00D

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Abstract

The present invention provides an iron metabolism-related protein marker composition and application thereof for high myopia risk prediction and high myopia auxiliary diagnosis. Specifically, the present invention provides a biomarker composition composed of serum transferrin, ferritin light chain and ferritin heavy chain and its kit, which are applied to predict the risk of high myopia and high myopia in the subject to be tested. auxiliary diagnosis. In addition, the present invention also provides a marker composition or method for screening candidate compounds for preventing, delaying or treating high myopia.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a marker composition for risk prediction of high myopia and auxiliary diagnosis of high myopia and its application. In addition, the present invention also relates to a marker composition or method for screening candidate compounds for preventing, delaying or treating high myopia. Background technique [0002] Myopia, as a disease with high incidence in the world, has received more and more attention at home and abroad in recent years. At the same time, myopia is also the main reason affecting the visual health of young people in our country, and it is also a major public health problem that our country is facing. According to statistics from the Ministry of Education in 2018, the overall myopia rate of young people in my country is 53.6%, which is much higher than other countries and regions in the world. Among them, the myopia rate of junior high school students and high ...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/68G01N27/62
CPCG01N33/6893G01N33/6848G01N2333/79G01N2333/47G01N2800/16G01N2800/60G01N2500/20
Inventor 陈静乙王雁吴文静
Owner TIANJIN EYE HOSPITAL OPTOMETRIC DEPT
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