Research on protective effect of curcumin on Cyprinus carpio liver injury by activating Nrf2 activity

A protective effect, the technology of curcumin, is applied in the research on the protective effect of curcumin on carp liver damage by activating Nrf2 activity. tract damage, etc.
CN113209062APending Publication Date: 2021-08-06FRESHWATER FISHERIES RES INST OF SHANDONG PROVINCE
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
FRESHWATER FISHERIES RES INST OF SHANDONG PROVINCE
Publication Date
2021-08-06

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Abstract

The invention discloses a research on a protective effect of curcumin on Cyprinus carpio liver injury by activating Nrf2 activity. The research comprises three tests, wherein the first test is to research the influence of curcumin with different addition amounts on the growth performance of Cyprinus carpio; the second test is to research the influence of curcumin on carbon tetrachloride (CCl4) induced fish liver injury; and the third test is to research the recovery effect of curcumin on carbon tetrachloride induced acute liver injury of Cyprinus carpio. According to the research disclosed by the invention, 120mg / kg of curcumin is added into the feed, and the Nrf2 activity can be improved to promote transfer of the Nrf2 into nucleus so as to improve the antioxidant state of Cyprinus carpio, so that the antioxidant enzyme activity is improved, and the Cyprinus carpio is finally protected from CCl4 liver injury. In addition, the research result also proves that the curcumin added into the feed has a recovery effect on acute liver injury of Cyprinus carpio.
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Description

technical field

[0001] The invention relates to a study on the protective effect of curcumin on carp liver damage, in particular to a study on the protective effect of curcumin on carp liver damage by activating Nrf2 activity, and belongs to the field of freshwater biological applications. Background technique

[0002] In recent years, the development of aquaculture in my country has gradually moved closer to a high-density and intensive farming model, with a rapid increase in breeding density, large-scale feeding of artificial compound feed, non-standard use of drugs and hormones, deteriorating aquaculture water environment, feed There are more and more unfavorable factors such as the existence of harmful substances in the feed and the lack and imbalance of feed nutrients, which put a huge pressure on the fish itself, make the metabolic system unbalanced, especially the damage to the liver function is particularly huge, and eventually lead to fish hepatobiliary syndrome The l...

Claims

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