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Research on protective effect of curcumin on Cyprinus carpio liver injury by activating Nrf2 activity

A protective effect, the technology of curcumin, is applied in the research on the protective effect of curcumin on carp liver damage by activating Nrf2 activity. tract damage, etc.

Pending Publication Date: 2021-08-06
FRESHWATER FISHERIES RES INST OF SHANDONG PROVINCE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, studies on curcumin's antioxidant and liver damage protection are mostly found in mice ( Mus musculus ) and livestock and poultry, the results of the research all show that curcumin has an effect on mice or broiler chickens ( Gallus gallus ) and other animals have a protective effect on liver damage, but fish research in this area is rare, only Yu Yunzhen et al. Ctenopharynodon idellus ) research on the protective effect of acute liver injury. However, in this study, curcumin was administered by intragastric administration. This method is difficult to operate and has certain damage to the digestive tract function of fish. It is not suitable for large-scale breeding processes.

Method used

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  • Research on protective effect of curcumin on Cyprinus carpio liver injury by activating Nrf2 activity
  • Research on protective effect of curcumin on Cyprinus carpio liver injury by activating Nrf2 activity
  • Research on protective effect of curcumin on Cyprinus carpio liver injury by activating Nrf2 activity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] The curcumin of embodiment one different addition amount is to carp ( Cyprinus carpio ) Effects on Growth Performance

[0069] Ⓐ Selection of test subjects and breeding management

[0070] Carp fry were provided by the Fine Breed Farm of Shandong Freshwater Fisheries Research Institute.

[0071] Before the start of the test, first use the sinking feed provided by Tongwei Feed Company to raise temporarily for 21 days, then randomly select 540 fish fry with basically the same size, specification and constitution, and divide them into 6 groups, with 3 fish in parallel in each group. 30 parallel fish were put into 18 circulating water culture buckets respectively, and the water volume of the culture bucket was 250 L.

[0072] The breeding tanks used in each group of experiments were randomly scattered and arranged in space to reduce the error caused by factors such as light among the test groups.

[0073] Feed 3 times a day with full food, the feeding time is 8:30, 12:3...

Embodiment 2

[0105] Embodiment two curcumin is to carbon tetrachloride (CCl 4 ) to induce fish liver damage

[0106] Ⓐ Effects of curcumin on blood and liver function indexes of carp liver injury induced by carbon tetrachloride

[0107] The kits used in this study were purchased from Nanjing Jiancheng Bioengineering Institute.

[0108] The plasma stored in the refrigerator at ‒80°C in Example 1 was taken out and dissolved in a refrigerator at 4°C, and the contents of total protein (TP), aspartate transaminase (GOT), alanine aminotransferase (GPT) and total antioxidant in plasma were determined. Capability (T-AOC).

[0109] Table 3CCl 4 Effects of pre-induction curcumin on carp plasma liver function indexes

[0110] Table3. Effects of dietary curcumin supplementation on the plasmaphysiological indexes of Cyprinus carpio before CCl 4 -challenged

[0111] n =9;

[0112]

[0113] Note: There is a significant difference between the mean values ​​of the two groups without the sam...

Embodiment 3

[0157] Example 3 Study on the Recovery Effect of Curcumin on Carp Acute Liver Injury Induced by Carbon Tetrachloride

[0158] Ⓐ Effects of curcumin on carp plasma liver function indexes at different time points after carbon tetrachloride induction

[0159] The kits used in this study were purchased from Nanjing Jiancheng Bioengineering Institute.

[0160] The plasma stored in the ‒80°C refrigerator in Example 1 was taken out and placed in a 4°C refrigerator to dissolve, and the contents of aspartate aminotransferase (GOT), alanine aminotransferase (GPT) and total antioxidant capacity (T-AOC) were determined.

[0161] Such as Figure 6A and Figure 6B It can be seen that adding curcumin in the feed has a significant effect on the acute liver injury induced by carbon tetrachloride in carp after feeding for a period of time, and within a period of time, the GPT and GOT activities in the plasma of fish vary with the amount of curcumin added. Also different. When induced by car...

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Abstract

The invention discloses a research on a protective effect of curcumin on Cyprinus carpio liver injury by activating Nrf2 activity. The research comprises three tests, wherein the first test is to research the influence of curcumin with different addition amounts on the growth performance of Cyprinus carpio; the second test is to research the influence of curcumin on carbon tetrachloride (CCl4) induced fish liver injury; and the third test is to research the recovery effect of curcumin on carbon tetrachloride induced acute liver injury of Cyprinus carpio. According to the research disclosed by the invention, 120mg / kg of curcumin is added into the feed, and the Nrf2 activity can be improved to promote transfer of the Nrf2 into nucleus so as to improve the antioxidant state of Cyprinus carpio, so that the antioxidant enzyme activity is improved, and the Cyprinus carpio is finally protected from CCl4 liver injury. In addition, the research result also proves that the curcumin added into the feed has a recovery effect on acute liver injury of Cyprinus carpio.

Description

technical field [0001] The invention relates to a study on the protective effect of curcumin on carp liver damage, in particular to a study on the protective effect of curcumin on carp liver damage by activating Nrf2 activity, and belongs to the field of freshwater biological applications. Background technique [0002] In recent years, the development of aquaculture in my country has gradually moved closer to a high-density and intensive farming model, with a rapid increase in breeding density, large-scale feeding of artificial compound feed, non-standard use of drugs and hormones, deteriorating aquaculture water environment, feed There are more and more unfavorable factors such as the existence of harmful substances in the feed and the lack and imbalance of feed nutrients, which put a huge pressure on the fish itself, make the metabolic system unbalanced, especially the damage to the liver function is particularly huge, and eventually lead to fish hepatobiliary syndrome The l...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/12A61P1/16A61K49/00A01K61/13
CPCA61K31/12A61P1/16A61K49/0008A01K61/13Y02A40/81
Inventor 张媛媛姚芳斌成慧中王晓丽
Owner FRESHWATER FISHERIES RES INST OF SHANDONG PROVINCE
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