Lactobacillus paracasei capable of antagonizing pharyngitis pathogenic bacterium beta hemolytic streptococcus

Abstract

The invention provides a lactobacillus paracasei AR340 strain capable of antagonizing pharyngitis pathogenic bacteria beta hemolytic streptococcus. The lactobacillus paracasei AR340 strain is preserved in the general microbiological center of the China Committee for Culture Collection of Microorganisms, the preservation number is CGMCC No.15762, and the preservation time is May 14, 2018. The lactobacillus paracasei AR340 strain disclosed by the invention has good self-agglutination capacity, copolymerization capacity and hydrophobic property, namely, the lactobacillus paracasei AR340 strain is not massively gathered in a pharynx and an oral cavity, and meanwhile, a certain amount of thalli are ensured to be adhered to the oral mucosa to play a role, so that the self-agglutination of the beta hemolytic streptococcus strain is reduced to a certain extent, and the survival rate of pathogenic bacteria is reduced; and the strain can effectively antagonize the growth of pharyngitis pathogenic bacteria beta hemolytic streptococcus, can reduce the generation amount of macrophage NO, and can be used for regulating pharyngeal flora, relieving inflammatory response and preventing, relieving or treating infection symptoms caused by the pharyngitis pathogenic bacteria beta hemolytic streptococcus.

Description

technical field [0001] The invention belongs to the field of biotechnology, in particular to the field of production and development of functional lactic acid bacteria, in particular to Lactobacillus paracasei which antagonizes pharyngitis pathogenic bacteria B-hemolytic Streptococcus. Background technique [0002] Pharyngitis is the inflammation of pharyngeal mucosa and submucosal tissue, often a part of upper respiratory tract infection, mainly with symptoms of discomfort such as sore throat, dry itching, nausea, and desire to vomit, and is also one of the most common diseases in the world. Under the invasion of beta-hemolytic streptococcus, Klebsiella pneumoniae, Haemophilus parainfluenzae, Staphylococcus aureus and other pathogenic bacteria, the flora of the pharynx is out of balance, the diversity of flora changes, and the dominant flora of origin decreases, The increase of opportunistic pathogenic bacteria will cause the decrease of the antagonistic ability of the nati...

AI Technical Summary

Problems solved by technology

[0004] In recent years, foreign studies have shown that probiotics have the effect of relieving and treating pharyngitis. Streptococcus salivarius K12 can effectively colonize oral mucosal cells. Clinical verification can prevent pharyngitis caused by streptococcus. There are few domestic reports , the only patent "probiotic food composition and food with the effect of relieving throat inflammation" (authorized announcement number: CN103798392B) mainly uses Lactobacillus salivarius which has the ability to resist gastric Helicobacter pylori and increases the content of active isoflavones in animals Mycobacterium as probiotics in the treatment of pharyngitis

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