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Material for spinal cord injury repair and preparation method of bone spinal cord tissue engineering scaffold

A tissue engineering scaffold and spinal cord injury technology, applied in the field of regenerative medicine and biomaterials, can solve the problems of difficult to effectively promote the repair of spinal cord injury, the inability to simulate the structure of the spinal cord, and the inconvenience of preparation, etc., to achieve good bionic spinal cord tissue structure, good Restorative effect, easy preparation effect

Active Publication Date: 2021-08-20
AFFILIATED HOSPITAL OF YOUJIANG MEDICAL UNIV FOR NATTIES +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is: the existing materials for spinal cord injury repair are difficult to effectively promote the repair of spinal cord injury, the preparation is inconvenient and the cost is high, and the normal spinal cord structure cannot be well simulated

Method used

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  • Material for spinal cord injury repair and preparation method of bone spinal cord tissue engineering scaffold
  • Material for spinal cord injury repair and preparation method of bone spinal cord tissue engineering scaffold
  • Material for spinal cord injury repair and preparation method of bone spinal cord tissue engineering scaffold

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Embodiment 1

[0045] Embodiment 1: This embodiment provides a kind of material for spinal cord injury repair, and described material comprises the following components by weight part number: Organic polymer material-polycaprolactone (PCL) 10 parts, organic solvent trifluoroethanol 50 parts, 2 parts of deionized water, 10 parts of supramolecular hydrogel material, and 1 part of drug Oxymatrine (OMT). The supramolecular hydrogel material is water, gelatin, double bonded β-cyclodextrin, polyethylene glycol diacrylate (PEGDA) with molecular weight 700-10000, spinal cord extracellular matrix, and photoinitiator, wherein water: Gelatin: double-bonded β-cyclodextrin: polyethylene glycol diacrylate (PEGDA): spinal cord extracellular matrix: UV photoinitiator is 100 parts: 12 parts: 8 parts: 1 part: 10 parts: 0.1 parts. The drug is Oxymatrine (OMT), which has the effect of reducing tissue fiber scar formation.

[0046] Utilize above-mentioned material for spinal cord repair to prepare bone and spin...

Embodiment 2

[0065] Embodiment 2: This embodiment provides a kind of material for repairing spinal cord injury, and described material comprises the following components by weight: 25 parts of organic macromolecular material polyglycolic acid (PGA), 75 parts of organic solvent trifluoroethanol , 14 parts of deionized water, 20 parts of supramolecular hydrogel material, and 1 part of drug Oxymatrine (OMT). The supramolecular hydrogel material is water, gelatin, double-bonded β-cyclodextrin, polyethylene glycol diacrylate (PEGDA) with a molecular weight of 700-10000, spinal cord extracellular matrix, and photoinitiator, wherein water: Gelatin: double-bonded β-cyclodextrin: polyethylene glycol diacrylate (PEGDA): spinal cord extracellular matrix: UV photoinitiator is 100 parts: 12 parts: 8 parts: 1 part: 10 parts: 0.1 parts, The drug Oxymatrine (OMT) has the effect of reducing tissue fibrous scarring.

[0066] Utilize above-mentioned material for spinal cord repair to prepare bone and spinal...

Embodiment 3

[0085] Embodiment 3: This embodiment provides a kind of material for spinal cord injury repair, and described material comprises the following components by weight: 40 parts of organic polymer material polylactic acid (PLA), 100 parts of organic solvent trifluoroethanol, 30 parts of deionized water, 30 parts of hydrogel material, and 1 part of drug Oxymatrine (OMT); the supramolecular hydrogel material includes water, gelatin, double-bonded β-cyclodextrin, polyethylene with a molecular weight of 700-10000 Glycol diacrylate (PEGDA), spinal cord extracellular matrix and photoinitiator, in which water: gelatin: double-bonded β-cyclodextrin: polyethylene glycol diacrylate (PEGDA): spinal cord extracellular matrix: ultraviolet light initiation The dosage is 100 parts: 12 parts: 8 parts: 1 part: 10 parts: 0.1 part. The drug Oxymatrine (OMT) has the effect of reducing tissue fibrous scarring.

[0086] Utilize above-mentioned material for spinal cord repair to prepare bone and spinal...

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Abstract

The invention relates to the technical field of regenerative medicine and biological materials, and discloses a material for spinal cord injury repair and a preparation method of a bone spinal cord tissue engineering scaffold. The material for spinal cord injury repair comprises the following components in parts by weight: 10-40 parts of an organic polymer material, 50-100 parts of an organic solvent, 2-30 parts of water, 10-30 parts of a hydrogel material and 0-1 part of a drug. The raw materials for spinal cord injury repair are common raw materials, are easy to obtain and rich in resources, and provide convenient conditions for the popularization and application of the bone spinal cord tissue engineering scaffold.

Description

technical field [0001] The invention relates to the technical fields of regenerative medicine and biomaterials, in particular to a preparation method of a material for spinal cord injury repair and bone and spinal cord tissue engineering scaffold. Background technique [0002] Currently, more than 27 million people worldwide are disabled due to spinal cord injury. Spinal cord injuries can have a variety of causes, including trauma, inflammation, infection, vascular causes, tumors, or degeneration. 90% of them are caused by trauma. For example, factors such as spinal trauma often lead to vertebral fractures, which compress the spinal cord parenchyma and cause spinal cord injury and the death of spinal cord neurons. After the death of spinal cord neurons, the interrupted nerve bundles cannot transmit information, resulting in multi-system dysfunction and sensory, motor, and autonomic dysfunction. Neurological dysfunction. Spinal cord injuries often result in permanent defic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/36A61L27/22A61L27/20A61L27/50A61L27/54A61L27/56B33Y70/10B33Y80/00
CPCA61L27/18A61L27/3633A61L27/3675A61L27/3687A61L27/3691A61L27/222A61L27/20A61L27/50A61L27/54A61L27/56B33Y70/10B33Y80/00A61L2430/32A61L2300/412A61L2300/204C08L67/04C08L71/02C08L5/16
Inventor 刘佳唐毓金谢克恭宋世强赵兴昌李凯杨成亮王翀王立强黄可
Owner AFFILIATED HOSPITAL OF YOUJIANG MEDICAL UNIV FOR NATTIES
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