Nuclear magnetic resonance phase-sensitive two-dimensional J decomposition spectrum method for inhibiting strong coupling pseudo peak

Abstract

The invention provides a nuclear magnetic resonance phase-sensitive two-dimensional J decomposition spectrum method for inhibiting a strong coupling pseudo peak. The method is used for multi-peak analysis of a complex chemical sample, and relates to the field of magnetic resonance spectroscopy detection. According to the method, two chirp sweep frequency pulses in opposite directions are adopted to achieve the purpose of restraining strong coupling pseudo peaks, a PSYCHE module is used for acquiring pure chemical shift information at a direct dimension, the evolution effect of J coupling is eliminated, J coupling information is recovered again through the effect of refocusing chemical shift by a J sampling module at an indirect dimension, and data post-processing is performed on a collected original signal to obtain a nuclear magnetic resonance phase-sensitive J decomposition spectrum for inhibiting the strong coupling pseudo peak. The effect of inhibiting the strong coupling pseudo peak is remarkable, and the method has extremely important significance on research of pure chemical shift in a magnetic resonance spectrum.

Description

technical field [0001] The invention relates to the field of magnetic resonance spectroscopy detection, in particular to a nuclear magnetic resonance phase-sensitive two-dimensional J-decomposition method for suppressing strong coupling false peaks Background technique [0002] NMR spectroscopy is an important technology in the field of NMR, in which the study of pure chemical shifts and J coupling constants plays a pivotal role, and is often used in molecular structure analysis of substances, object detection and other fields. At this stage, NMR spectroscopy technology faces many challenges, including 1 The narrow chemical shift distribution range (0-15ppm) and extensive J-coupling splitting of the H nucleus in the one-dimensional spectrum make the chemical shift and J-coupling information displayed in the one-dimensional spectrum very crowded, which is not conducive to people's analysis of the molecular structure. Therefore, most of these studies display information in th...

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Problems solved by technology

However, there are two problems in the conventional 2DJ spectrum: 1. The collected signal is affected by the phase modulation of the evolution period and the sampling period, so that the signal has a phase distortion problem when it is displayed in the spectrogram

In a strong coupling system, the strong coupling artifact signal is mainly caused by the strong coupling effect of the 180° non-selective hard pulse, and the strong coupling artifact signal is consistent with the coherent path of the sampled target signal, so it cannot pass the phase The cyclic method suppresses the artifact signal of strong coupling. Even the two-dimensional spectrum with phase-sensitive processing still cannot improve the problem of strong coupling artifact peaks in the strong coupling system.

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