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Medicine for treating meniere's disease and application thereof

A technology of Meniere's disease and drugs, which is applied in the field of drugs for the treatment of Meniere's disease, can solve the problems that there is no cure for this disease, and the etiology and pathogenesis of Meniere's disease are unknown, so as to improve Meniere's disease. Symptoms, relieving rotation, enhancing the effect of treatment or relief

Pending Publication Date: 2021-08-24
BEIHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Since the etiology and pathogenesis of Meniere's disease are unknown, there is currently no cure for the disease

Method used

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  • Medicine for treating meniere's disease and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1: preparation pharmaceutical preparation

[0020] Take 100g of ebselen and 10g of acetazolamide, add 80g of starch, 30g of croscarmellose sodium and 3g of magnesium stearate, and press it into a tablet of 4mg of ebselen / tablet.

Embodiment 2

[0027] Embodiment 2: Anti-Ménière's symptom pharmacodynamic experiment

[0028] 50 guinea pigs weighing 240-300 grams were used in the experiment, half male and half male, and randomly divided into groups of 10 guinea pigs. Fasting without water for 12 hours before the experiment, each of the placebo group, the positive control group and the test group was given 1 tablet by intragastric administration, and the model group was not given any drug administration, and the experiment was carried out 4 hours after the administration.

[0029] Accurately inject 20 μL of chloroform into the deep part of the external auditory canal through a thin plastic tube. Usually, clinical symptoms appear about 10 minutes after administration: the whole body rotates rapidly to the administration side, usually 15-20 minutes after administration of chloroform Appears, then stops and rotates, and stops in about 60-80 minutes. This is the most serious symptom. The number of rotations within 2 hours is...

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PUM

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Abstract

The invention relates to a medicine for treating Meniere's disease and application thereof, the medicine comprises the active components of ebbuselenium and acetazolamide, and the weight ratio of ebbuselenium to acetazolamide is (8-12): 1. The acetazolamide and the ebbeselenium are combined according to a certain proportion, through synergistic interaction, the Meniere's disease can be effectively treated or relieved, and particularly, rotation, eyeball tremor and left-right swing of the head caused by the Meniere's disease can be relieved at the same time.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a medicine for treating Meniere's disease and its application. Background technique [0002] Meniere's disease (MD) is defined as the triad of episodic vertigo, hearing loss and tinnitus. It was once called Meniere's disease and was first proposed by a French physician in 1861. Ear pressure or aural fullness are frequently reported, and most auditory and vestibular symptoms fluctuate in frequency and intensity. Although the etiology of MD is unknown, it is associated with endolymphedema. Endolymphedema is swelling of the inner lymphatic compartment of the inner ear. After an acute phase in which vertigo is the most common feature, a chronic phase occurs in which hearing loss and tinnitus become the most common features, although balance disturbances are often reported. [0003] Since the etiology and pathogenesis of Meniere's disease are unknown, there is currentl...

Claims

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Application Information

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IPC IPC(8): A61K31/433A61P27/16A61K31/41
CPCA61K31/41A61K31/433A61P27/16A61K2300/00
Inventor 李中华聂宇航孟晶
Owner BEIHUA UNIV
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