Unlock instant, AI-driven research and patent intelligence for your innovation.

Artificial intelligence biosensor detection method for detecting use of chlortrimeton

A biosensor, artificial intelligence technology, applied in the field of pharmacy, can solve the problem of less research on therapeutic use

Active Publication Date: 2021-09-03
BEIJING UNIV OF CHINESE MEDICINE
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is only used as an H1 receptor blocker, and there are few studies on other therapeutic uses

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Artificial intelligence biosensor detection method for detecting use of chlortrimeton
  • Artificial intelligence biosensor detection method for detecting use of chlortrimeton
  • Artificial intelligence biosensor detection method for detecting use of chlortrimeton

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1 Preparation of a Syk-AlGaAs / GaAs HEMT artificial intelligence biosensor

[0040] A kind of preparation of Syk-AlGaAs / GaAs HEMT artificial intelligence biosensor, concrete steps are as follows:

[0041] (1) Using the AlGaAs / GaAs HEMT semiconductor material as the carrier, using the probe platform and electrochemical workstation, measure the source and drain current I of each channel of the AlGaAs / GaAs HEMT device DS -V DS Curve, judge and compare the performance of each channel, and select the channel with excellent semiconductor performance as the test channel;

[0042] (2) Stick a sample tube on the clean AlGaAs / GaAs HEMT device, add 3-MPA solution to the sample tube, and react at room temperature for 24 hours to generate Au-S bonds on the surface of the AlGaAs / GaAs HEMT device, forming a self- Assemble a single layer;

[0043] (3) Suck off the 3-MPA in the sample tube, wash the remaining 3-MPA with deionized water, add an equal volume mixed aqueous sol...

Embodiment 2

[0046] Example 2 Preparation of a MIF-AlGaAs / GaAs HEMT artificial intelligence biosensor

[0047] A kind of preparation of MIF-AlGaAs / GaAs HEMT artificial intelligence biosensor, concrete steps are as follows:

[0048] (1) Using the AlGaAs / GaAs HEMT semiconductor material as the carrier, using the probe platform and electrochemical workstation, measure the source and drain current I of each channel of the AlGaAs / GaAs HEMT device DS -V DS Curve, judge and compare the performance of each channel, and select the channel with excellent semiconductor performance as the test channel;

[0049] (2) Stick a sample tube on the clean AlGaAs / GaAs HEMT device, add 3-MPA solution to the sample tube, and react at room temperature for 24 hours to generate Au-S bonds on the surface of the AlGaAs / GaAs HEMT device, forming a self- Assemble a single layer;

[0050] (3) Suck off the 3-MPA in the sample tube, wash the remaining 3-MPA with deionized water, add EDC with a concentration of 20mM and...

Embodiment 3

[0053] Example 3 Application of a Syk-AlGaAs / GaAs HEMT biosensor in the detection of chlorpheniramine combined with Syk

[0054] The application of a Syk-AlGaAs / GaAs HEMT biosensor in detecting chlorpheniramine combined with Syk, the specific steps are as follows:

[0055] (1) Preparation of the sample solution to be tested: take a piece of chlorpheniramine tablets (molecular weight: 390.86) with a specification of 4 mg and dissolve it in 10 mL of PBS solution with a concentration of 0.1 M, mix well, and pass through a 0.45 μL microporous membrane, that is Obtain a chlorpheniramine solution with a concentration of about 1.0 mM; dilute it by 10 times the concentration to obtain a 0.1 mM solution, then dilute it 3 times according to a 1000-fold concentration gradient to obtain 0.1 μM, 0.1 nM, and 0.1 pM chlorpheniramine solutions successively, for subsequent use;

[0056] (2) With the Syk-AlGaAs / GaAs HEMT biosensor prepared in embodiment 1 as the reaction device, add the chlorph...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides application of an artificial intelligence biosensor detection method in detection of the use of chlortrimeton. According to an artificial intelligence biosensor, an AlGaAs / GaAs HEMT device is used as a transducer, Syk protein and MIF protein modifying a HEMT device are used as recognition original elements, and two biosensors including a Syk-AlGaAs / GaAs HEMT biosensor and a MIF-AlGaAs / GaAs HEMT biosensor are constructed through self-assembly of single layers, the two biosensors are used for identifying the potential inhibition effect of chlortrimeton on the Syk and MIF. The sensitivity is high, the detection concentration is as low as 0.1 pM, the detection range covers 5-10 orders of magnitude, and data support is provided for expanding adaptation diseases of chlortrimeton tablets.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to an application method of an artificial intelligence biosensor detection method in the detection of chlorpheniramine. Background technique [0002] With the continuous changes in the spectrum of human diseases, the clarification of disease mechanisms, and the integration of medical concepts, drug databases also need to be updated urgently. However, the investment in new drug research and development is large, the output is small, and the success rate is less than 10%. Advances in drug therapy such as new use of old drugs and multiple uses of one drug have promoted the safe and effective clinical use of many doctors. In the past few decades, the FDA has officially approved many examples of new uses of old drugs. For example, aspirin, a conventional anti-inflammatory and analgesic drug, has been confirmed to thin blood, prevent thrombosis and reduce the incidence of stroke; It i...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/414
CPCG01N27/4145
Inventor 吴志生马丽娟
Owner BEIJING UNIV OF CHINESE MEDICINE