Preparation method of beta-propiolactone

Abstract

The invention relates to a preparation method of beta-propiolactone, the preparation method comprises the following steps: (1) dissolving 3-halogenated propionic acid in an organic solvent at a room temperature, stirring, cooling to a temperature of 0 DEG C or less, and adding organic amine to obtain a solution A; preparing alkali liquor below 0 DEG C as a solution B; (2) mixing the solution A and the solution B under stirring at 0-2 DEG C, then heating to 4-6 DEG C, carrying out a heat preservation reaction, stopping stirring after the reaction is completed, cooling to 0 DEG C, and standing to generate split phases; and (3) washing the organic phase obtained by phase splitting with salt water, cooling to 0 DEG C or below, washing with water, drying, desolventizing to obtain a crude product beta-propiolactone, and distilling to obtain the product beta-propiolactone. According to the method, the reaction technology combining extraction and phase transfer is adopted, the reaction is carried out at low temperature, beta-propiolactone can be prepared at high yield, the used raw materials are easy to obtain, the cost is low, the preparation process is simple, and the method is suitable for industrial production.

Description

technical field

[0001] The invention relates to the technical field of organic chemistry, in particular to a preparation method of β-propiolactone. Background technique

[0002] β-propiolactone, also known as beta-propiolactone, is a heterocyclic compound with a molecular number of C 3 h 4 o 2 , with a molecular weight of 72.06. It is a colorless viscous liquid at normal temperature, with a faint sweet taste and a boiling point of 162.3°C, soluble in water. Has a strong inactivation effect on viruses. It has been widely used in the inactivation of various vaccines abroad, acting on the DNA or RNA of pathogens, changing the structure of viral nucleic acid to achieve the purpose of inactivation. β-propiolactone directly interacts with viral nucleic acid instead of capsid protein, and does not destroy the immunogenicity of pathogens. Although a large dose of β-propiolactone (BPL) is a carcinogen, it is easily hydrolyzed and disappears after being hydrolyzed in a water bat...

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