Unlock instant, AI-driven research and patent intelligence for your innovation.

Application of biomarker in prediction of lung cancer prognosis

A biomarker and prognostic technology, applied in the field of disease diagnosis, can solve problems such as the limitation of the predictive ability of the TNM staging system

Pending Publication Date: 2021-09-24
BEIJING MEDINTELL BIOMED CO LTD
View PDF0 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the prediction ability of TNM staging system is also limited, so there is an urgent need for new markers that can accurately predict the prognosis of lung cancer patients (Shi X, Li R, Dong X et al. IRGS: an immune-related gene classifier for lung adenocarcinomaprognosis. Journal of translational medicine, 18(1), 55(2020).)

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of biomarker in prediction of lung cancer prognosis
  • Application of biomarker in prediction of lung cancer prognosis
  • Application of biomarker in prediction of lung cancer prognosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0043] Some aspects and embodiments of the invention will now be discussed with reference to the accompanying drawings. Other aspects and embodiments will become apparent to those skilled in the art. All documents mentioned herein are hereby incorporated by reference.

[0044] sample

[0045] A "sample" as used herein may be a cell or tissue sample (eg, a biopsy), a biological fluid, an extract (eg, a protein or DNA extract obtained from a subject). In particular, the sample may be a tumor sample, such as a solid tumor, such as lung adenocarcinoma. A sample may be a sample obtained fresh from a subject, or may be a sample that has been processed and / or stored (eg, frozen, fixed, or subjected to one or more purification, enrichment, or extraction steps) prior to determination.

[0046] "And / or" as used herein is to be read as a specific disclosure of each of the two specified features or components with or without the other. For example, "A and / or B" would be considered a s...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses application of a biomarker in prediction of lung cancer prognosis. According to the invention, through single-factor Cox regression analysis, the genes related to the survival time of the lung cancer are screened out, a model for predicting the prognosis of the lung cancer is further constructed through a multi-factor Cox regression model, and the model can independently predict the prognosis condition of a patient with the lung cancer.

Description

technical field [0001] The present invention relates to the field of disease diagnosis, more specifically, the present invention relates to the application of biomarkers in predicting the prognosis of lung cancer. Background technique [0002] Lung cancer is the most common malignant tumor in the world, and its morbidity and mortality rank first among men and women (Bray F, Ferlay J, et al. Global cancer mortality worldwide for 36 cancers in 185 countries. CA: a cancer journal for clinicians, 68 (6), 394-424(2018)). Lung cancer is divided into small cell lung cancer (small cell lung cancer, SCLC) and non-small cell lung cancer (non-small cell lung cancer, NSCLC), 80-85% of lung cancer patients are NSCLC. NSCLC is mainly divided into three histological types, namely lung adenocarcinoma, lung squamous cell carcinoma and large cell carcinoma, among which lung adenocarcinoma is the main histological type, accounting for about 40% (Bender E. Epidemiology: The dominant malignancy...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886G01N33/574G01N33/68G16B5/00G16B25/10G16H50/30G16H50/50
CPCC12Q1/6886G01N33/57423G01N33/57484G01N33/57488G01N33/68G16B5/00G16B25/10G16H50/30G16H50/50C12Q2600/118C12Q2600/158G01N2333/47
Inventor 杨承刚李雨晨刘乐凯王丹
Owner BEIJING MEDINTELL BIOMED CO LTD