188Re-labeled degradable nano-probe for breast cancer diagnosis and treatment and preparation method thereof

A nanoprobe, 188re technology, applied in the field of tumor treatment, can solve the problem of not significantly prolonging the survival time of patients
CN113456841APending Publication Date: 2021-10-01GENERAL HOSPITAL OF NUCLEAR IND
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
GENERAL HOSPITAL OF NUCLEAR IND
Publication Date
2021-10-01

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Abstract

The invention discloses a 188Re-labeled degradable nano-probe for breast cancer diagnosis and treatment and a preparation method, the 188Re-labeled degradable nano-probe for breast cancer diagnosis and treatment comprises a nano-probe, and the nano-probe is formed by coating an IDO inhibitor with PLGA nano-particles, the nano-probe comprises the following components by molar mass: 4-6 mol of lactide, 1-2 mol of glycolide, an initiator, a surfactant, an IDO inhibitor and a dispersant, the nano-probe is connected with folic acid for targeting 4T1 breast cancer, and is connected with 188Re for targeted tracking of breast cancer and lymph node metastasis, SPECT imaging and internal irradiation sensitization treatment. The degradable nano-probe disclosed by the invention can realize targeted tracking, SPECT imaging and internal irradiation sensitization precise treatment of breast cancer and lymph node metastasis, and realizes diagnosis and treatment integration of breast cancer.
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Description

technical field

[0001] The invention relates to the technical field of tumor treatment, in particular to 188 Re-labeled degradable nano-probe for diagnosis and treatment of breast cancer and preparation method. Background technique

[0002] Breast cancer is the female tumor with the first incidence rate and the second mortality rate, which seriously endangers women's life, health and quality of life. One of the main reasons for the high mortality rate of breast cancer is that the early detection rate is low, often diagnosed in the middle and late stages, and the best treatment opportunity is lost. Therefore, accurate early diagnosis of breast cancer is of great significance.

[0003] X-ray mammography, breast ultrasound and breast magnetic resonance (MRI) examinations are the most commonly used methods for clinical diagnosis of breast cancer. However, these diagnostic methods have certain defects, such as: X-ray mammography examination is not easy to detect small tumors w...

Claims

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