Calixarene-rhodamine supramolecular co-assembly as well as preparation method and application thereof

A co-assembly, supramolecular technology, applied in chemical instruments and methods, analytical materials, measurement devices, etc., can solve problems such as nucleic acid and protein hazards

Active Publication Date: 2021-10-01
GUIZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, although iron ions are very active in metabolic processes such as cell metabolism, oxygen transport, and electron transfer, excessive iron ions will cause great harm to nucleic acids and proteins

Method used

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  • Calixarene-rhodamine supramolecular co-assembly as well as preparation method and application thereof
  • Calixarene-rhodamine supramolecular co-assembly as well as preparation method and application thereof
  • Calixarene-rhodamine supramolecular co-assembly as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Embodiment 1: Preparation of calixarene-rhodamine co-assembly:

[0045] a. Mix rhodamine (50mg, 0.104mmol) and 4-sulfonylcalix[4]arene hydrate (225mg, 0.302mmol) into hydrochloric acid solution (6mol / L, 15mL), stir to dissolve, and obtain solution A ;

[0046] b. Transfer solution A to a stainless steel autoclave lined with 25mL polytetrafluoroethylene, keep the temperature at 100°C for 1 hour, then cool it to room temperature, transfer it to a beaker, and let it stand at room temperature for 2 days , to obtain crystal B;

[0047] c. Use the Bruker D8 VENTURE single crystal diffractometer to test the structure of crystal B to determine its molecular configuration and molecular formula. The molecular configuration is a solid triangle structure and the molecular formula is C 112 h 103 o 51 N 2 S 12 Cl, with a molecular weight of 2713.17;

[0048] d. Determination of crystal B 1 H NMR spectrum, to further determine the ratio of calixarene-rhodamine co-assembly, the...

Embodiment 2

[0050] Embodiment 2: Preparation of calixarene-rhodamine co-assembly:

[0051] 1) Rhodamine and 4-sulfonylcalix[4]arene hydrate are mixed in a ratio of less than 1:5 in the amount of substances and added to a hydrochloric acid solution with a concentration of 6mol / L, stirred to dissolve, and solution A is obtained;

[0052] 2) Add solution A into the autoclave, keep the temperature at 95°C for 1.5h, then cool it down to room temperature, let it stand for 1d to crystallize, and obtain crystal B;

[0053] 3) The crystal B described in step 2) is filtered out, and the crystal B is the calixarene-rhodamine supramolecular co-assembly.

Embodiment 3

[0054] Embodiment 3: the preparation of calixarene-rhodamine co-assembly:

[0055] 1) Rhodamine and 4-sulfonylcalix[4]arene hydrate are mixed in a ratio of less than 1:7 in terms of the amount of substances and added to a hydrochloric acid solution with a concentration of 6mol / L, stirred to dissolve, and solution A is obtained;

[0056] 2) Add solution A into the autoclave, keep the temperature at 105°C for 0.5h, then cool it down to room temperature, and let it stand for 3d to crystallize to obtain crystal B;

[0057] 3) The crystal B described in step 2) is filtered out, and the crystal B is the calixarene-rhodamine supramolecular co-assembly.

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Abstract

The invention discloses a calixarene-rhodamine supramolecular co-assembly as well as a preparation method and application thereof, the molecular formula of the calixarene-rhodamine supramolecular co-assembly is C112H103O51N2S12, and the calixarene-rhodamine supramolecular co-assembly can be used as a fluorescent probe for detecting Fe < 3 + > and Pb < 2 + > and the supramolecular co-assembly disclosed by the invention can be used as a fluorescence detection reagent for iron ions and palladium ions in an aqueous solution, and has the advantages of rapidness and effectiveness in detection, good selectivity, high sensitivity, low detection cost and low requirements on equipment.

Description

technical field [0001] The invention relates to a supramolecular co-assembly and its preparation method and application, in particular to a calixarene-rhodamine supramolecular co-assembly and its preparation method and application. Background technique [0002] Supramolecular assembly is defined as a multi-molecular group composed of non-covalent bonds, which can be as simple as two molecules. They can be spherical, rod-shaped or flake-like complex organized aggregates, and maintain a certain integrity, so that they have well-defined microstructure and macroscopic properties. [0003] Supramolecular assemblies have a wide range of applications. For example, Samuel 1.Stupp of Northwestern University and his colleagues indicated that the supramolecular assembly of peptide amphiphiles into nanofibers can be used to promote the growth of neurons; and biological / Self-assembling dendritic dipeptides (Self-assembling dendritic dipeptides) in materials science, which form empty cy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/82C07C309/42C09K11/06G01N21/64
CPCC07D311/82C07C309/42C09K11/06G01N21/6428C09K2211/1088
Inventor 肖昕岑然张威刘明冯贤豪王成会陈丽霞
Owner GUIZHOU UNIV
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