A kind of preparation method of unique extract nano-preparation

A nano-formulation, a unique technology, applied in the fields of nanotechnology, nanotechnology, nanomedicine, etc., can solve the problems of poor water solubility, low bioavailability, poor oral absorption, etc., to promote absorption, relieve chronic pain, and delay leakage. Effect

Active Publication Date: 2022-06-24
江西杏林白马药业股份有限公司
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For fat-soluble components such as shanzhiside methyl ester and 8-O-acetyl shanzhiside methyl ester, which have good hemostatic, blood-promoting and analgesic effects, although they have shown good performance in the medical field However, due to its poor water solubility, poor oral absorption and low bioavailability, the possibility of further clinical development is limited.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of preparation method of unique extract nano-preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] A unique nano preparation is composed of the following substances in parts by weight: 1 part of the unique flavor extract, 6 parts of lecithin, 5 parts of glycerides, 1 part of polysorbate 80, polyethylene oxide-polypropylene oxide - 3 parts of polyethylene oxide triblock copolymer, 3 parts of lyoprotectant;

[0045] The preparation method steps of the unique nano preparation are:

[0046] S1. Preparation of unique flavor powder: take unique flavor, pulverize, and sieve through a 40-mesh sieve to obtain unique flavor powder;

[0047] S2. Preparation of the unique flavor extract: subcritical extraction of the unique flavor powder with ethyl acetate as a solvent, the unique flavor and ethyl acetate are 1g:1mL according to the feeding ratio, the subcritical extraction temperature is 25 ℃, and the extraction time is 60min, The extraction pressure was 18MPa, and the ethyl acetate was removed by concentration under reduced pressure to obtain a unique extract;

[0048] S3. P...

Embodiment 2

[0054] A unique nano preparation is composed of the following substances in parts by weight: 5 parts of unique flavor extract, 10 parts of lecithin, 8 parts of glycerides, 3 parts of polysorbate 80, polyethylene oxide-polypropylene oxide - 3 parts of polyethylene oxide triblock copolymer, 3 parts of lyoprotectant;

[0055] The preparation method and preparation conditions are the same as those in Example 1.

[0056] The freeze-drying protection agent is trehalose.

[0057] The lecithin is phosphatidylcholine.

[0058] The glyceride is glyceryl distearate.

Embodiment 3

[0060] A unique nano preparation is composed of the following substances in parts by weight: 1 to 5 parts of the unique extract, 8 parts of lecithin, 5 parts of glycerides, 2 parts of polysorbate 80, polyethylene oxide-polycyclic 2 parts of oxypropylene-polyethylene oxide triblock copolymer, 3 parts of lyophilization protection agent;

[0061] The preparation method and preparation conditions are the same as those in Example 1.

[0062] The lecithin is soybean lecithin.

[0063] The glyceride is glyceryl laurate.

[0064] The lyoprotectant is glucose.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The object of the present invention is to provide a nano-preparation of the unique extract and a preparation method thereof. The nano-preparation of the unique extract of the present invention comprises the following materials in parts by weight: 1 to 5 parts of the unique extract, 6 parts of lecithin 1-10 parts, 5-8 parts of glyceride, 1-3 parts of polysorbate 80, 1-3 parts of polyethylene oxide-polypropylene oxide-polyethylene oxide triblock copolymer, 1-3 parts of lyoprotectant, the nano-preparation obtained by the preparation method of the present invention has the effect of alleviating chronic pain.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a preparation method of a nano-formulation of a unique extract. Background technique [0002] Pain is a subjective feeling and is a complex physiological and psychological activity. Pain is divided into acute pain and chronic pain. Chronic pain is not only about pain itself. In the process of chronic pain, long-term pain stimulation will promote the central nervous system, resulting in Pathological remodeling of the central nervous system occurs, leading to exacerbation of the disease. [0003] For chronic pain, it can be divided into nociceptive pain and neurogenic pain. Nociceptive pain is the response of intact nociceptors to noxious stimuli; while neurogenic pain is half when nerve fibers are damaged or abnormal changes in the nervous system occur. Spontaneous impulses occur, projecting pain sensations to the part where the nerve originates. [0004] ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/10A61K9/19A61K36/53A61K47/10A61K47/14A61K47/24A61K47/26A61P29/00A61P25/00B82Y5/00
CPCA61K36/53A61K9/10A61K9/19A61K47/10A61K47/14A61K47/24A61K47/26A61P29/00A61P25/00B82Y5/00A61K2236/37
Inventor 胡志文
Owner 江西杏林白马药业股份有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap