Pithecellobium clypearia extract nano preparation and preparation method thereof

A nano-preparation and monkey earring technology, which is applied in the direction of anti-inflammatory agents, anti-fungal agents, and drug combinations, can solve the problems of low bioavailability, limited clinical development, and poor oral absorption, and achieves simple preparation methods, increased chemical and Effects of Physical Stability, Increased Dissolution Rate and Solubility

Inactive Publication Date: 2020-04-17
江西杏林白马药业股份有限公司
View PDF8 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For fat-soluble components such as monkey earring ethyl acetate extract with good antibacterial and anti-inflammatory pharmacological activities, although they have shown good clinical application prospects in the medical field, because of their poor water solubility, poor oral absorption, and bioavailability It is also low, which limits the possibility of its further clinical development

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pithecellobium clypearia extract nano preparation and preparation method thereof
  • Pithecellobium clypearia extract nano preparation and preparation method thereof
  • Pithecellobium clypearia extract nano preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A nano-preparation of monkey earring extract, which consists of the following components by weight: 3 parts of monkey earring extract, 9 parts of lecithin, 7 parts of glyceride, 2 parts of poloxamer, and 2 parts of freeze-drying protective agent.

[0029] The preparation of nano-preparation of monkey earring extract comprises the steps:

[0030] 1) Take 1kg of monkey earrings, crush them, pass through a 150-mesh sieve, and use ethyl acetate as a solvent for subcritical extraction. The liquid-to-solid ratio is 1g:2ml. The subcritical extraction temperature is 30°C, the extraction time is 80min, and the extraction pressure is 20MPa. Concentrate under reduced pressure to remove ethyl acetate to obtain monkey earring extract;

[0031] 2) Add 0.90 g of glyceryl monostearate and 0.70 g of soybean lecithin to 400 mL of ethyl acetate, and after they are completely dissolved, add 0.30 g of monkey earring extract, and ultrasonically dissolve evenly to obtain the oil phase of monk...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
diameteraaaaaaaaaa
Login to view more

Abstract

The invention discloses a preparation method of a pithecellobium clypearia extract nano dry suspension. According to the method, a pithecellobium clypearia extract is used as a raw material, lecithin,glyceride and poloxamer are used as drug-loading matrixes, the raw material drug and the matrixes are mixed to form an oil phase and an oil-in-water phase, ultrasonic emulsification is performed through a probe to obtain a nano suspension, and then a freeze-drying agent is added for freeze-drying to obtain the pithecellobium clypearia extract nano dry suspension. The pithecellobium clypearia extract nano dry suspension prepared by the invention has the particle size of 40-180nm, has good drug loading capacity, can obviously improve the solubility and bioavailability of hydrophobic drugs, inhibit bacteria and diminishes inflammation, and has exact curative effect.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a monkey earring extract nano-preparation and a preparation method thereof. Background technique [0002] Pithecellobium clypearia Benth is a plant of the genus Pithecellobium clypearia Benth in the Fabaceae Mimosa subfamily. Its leaves, fruits, and seeds can be used as medicine. It has the functions of clearing away heat and detoxification, cooling blood, reducing swelling, and stopping diarrhea. In modern clinical practice, it is mainly used to treat upper respiratory tract infection, acute gastroenteritis, acute pharyngitis, and acute tonsillitis, and has obvious anti-influenza virus effects. Monkey ear ring anti-inflammatory granule has been widely used as anti-inflammatory and respiratory disease medicine, and its prescription is the water extract of monkey ear ring tender branches and leaves. For fat-soluble components such as monkey earring ethyl a...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/48A61K9/19A61K47/14A61K47/24A61K47/26A61P29/00A61P31/04A61P31/10A61K127/00A61K9/51
CPCA61K9/19A61K9/5123A61K36/48A61K47/14A61K47/24A61K47/26A61P29/00A61P31/04A61P31/10
Inventor 胡志文
Owner 江西杏林白马药业股份有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap