Lamiophlomis rotata extract nano preparation and preparation method thereof
A nano-preparation and unique technology, applied in the direction of anti-inflammatory agents, drug combinations, pharmaceutical formulations, etc., can solve the problems of low bioavailability, limited clinical development, poor oral absorption, etc., achieve simple preparation methods, increase chemical and physical Stability, Effects of Increased Dissolution Rate and Solubility
Inactive Publication Date: 2020-04-28
江西杏林白马药业股份有限公司
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Abstract
The invention discloses a preparation method of a lamiophlomis rotata extract nano dry suspension. According to the method, a lamiophlomis rotata extract is adopted as a raw material, lecithin, glyceride and poloxamer are adopted as drug carrying matrixes, the raw material medicine is mixed with the matrixes to form an oil phase and an oil-in-water phase, ultrasonic emulsification by a probe is carried out to obtain a nano mixed suspension, a dry-freezing agent is added to conduct dry freezing, and thus the lamiophlomis rotata extract nano dry suspension is prepared. The lamiophlomis rotata extract nano dry suspension prepared by using the method has a particle size of 40-180nm, has a large drug loading capacity, meanwhile, is remarkably improved in solubility and bioavailability of a hydrophobic drug terpene extract, stops bleeding and relieves pain and is definite in treatment effect.
Application Domain
Powder deliveryAntipyretic +7
Technology Topic
PoloxamerOil phase +12
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PUM
Property | Measurement | Unit |
Particle size | 40.0 ~ 80.0 | nm |
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