Lamiophlomis rotata extract nano preparation and preparation method thereof

Abstract

The invention discloses a preparation method of a lamiophlomis rotata extract nano dry suspension. According to the method, a lamiophlomis rotata extract is adopted as a raw material, lecithin, glyceride and poloxamer are adopted as drug carrying matrixes, the raw material medicine is mixed with the matrixes to form an oil phase and an oil-in-water phase, ultrasonic emulsification by a probe is carried out to obtain a nano mixed suspension, a dry-freezing agent is added to conduct dry freezing, and thus the lamiophlomis rotata extract nano dry suspension is prepared. The lamiophlomis rotata extract nano dry suspension prepared by using the method has a particle size of 40-180nm, has a large drug loading capacity, meanwhile, is remarkably improved in solubility and bioavailability of a hydrophobic drug terpene extract, stops bleeding and relieves pain and is definite in treatment effect.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a nano-preparation of unique herb extract and a preparation method thereof. Background technique [0002] Duyiwei is the dried whole herb of the genus Duyiwei in the family Lamiaceae. It is mainly distributed in Qinghai, Gansu, Sichuan and other provinces of China. It is a commonly used herbal medicine in Tibetan and Mongolian folk traditions. Promote blood circulation, promote stasis, reduce swelling, stop bleeding, and relieve pain. The main ingredients include iridoid glycosides, phenylethanol glycosides, and flavonoid glycosides. At present, the preparation process of various dosage forms including granules, capsules, dispersible tablets, effervescent tablets, and soft capsules has been disclosed in the existing patent technology of Duyiwei. Pharmacological effects of substances. For fat-soluble components such as shanzhiside methyl ester and 8-O-acet...

AI Technical Summary

Problems solved by technology

For fat-soluble components such as shanzhiside methyl ester and 8-O-acetyl shanzhiside methyl ester, which have good hemostatic, blood-promoting and analgesic effects, although they have shown good performance in the medical field However, due to its poor water solubility, poor oral absorption and low bioavailability, the possibility of further clinical development is limited.

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