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Lamiophlomis rotata extract nano preparation and preparation method thereof

A nano-preparation and unique technology, applied in the direction of anti-inflammatory agents, drug combinations, pharmaceutical formulations, etc., can solve the problems of low bioavailability, limited clinical development, poor oral absorption, etc., achieve simple preparation methods, increase chemical and physical Stability, Effects of Increased Dissolution Rate and Solubility

Inactive Publication Date: 2020-04-28
江西杏林白马药业股份有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

For fat-soluble components such as shanzhiside methyl ester and 8-O-acetyl shanzhiside methyl ester, which have good hemostatic, blood-promoting and analgesic effects, although they have shown good performance in the medical field However, due to its poor water solubility, poor oral absorption and low bioavailability, the possibility of further clinical development is limited.

Method used

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  • Lamiophlomis rotata extract nano preparation and preparation method thereof
  • Lamiophlomis rotata extract nano preparation and preparation method thereof
  • Lamiophlomis rotata extract nano preparation and preparation method thereof

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Embodiment 1

[0028] A nano-preparation of the unique extract, which is composed of the following components by weight: 3 parts of the unique extract, 9 parts of lecithin, 7 parts of glyceride, 2 parts of poloxamer, and 2 parts of lyoprotectant.

[0029] The preparation of unique extract nano-preparation comprises the following steps:

[0030] 1) Take 1 kg of Duyiwei, crush it, pass through a 150-mesh sieve, and use ethyl acetate as a solvent for subcritical extraction. The liquid-to-solid ratio is 1g: 2ml. The subcritical extraction temperature is 30°C, the extraction time is 80min, and the extraction pressure is 20MPa. Concentrate under reduced pressure to remove ethyl acetate to obtain the unique extract;

[0031] 2) Add 0.70g of glyceryl monostearate and 0.90g of soybean lecithin into 400ml of ethyl acetate, and after they are all dissolved, add 0.30g of the extract of Duyiwei, and ultrasonically dissolve it evenly to obtain the oil phase of the extract of Duyiwei ;

[0032] 3) Add th...

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Abstract

The invention discloses a preparation method of a lamiophlomis rotata extract nano dry suspension. According to the method, a lamiophlomis rotata extract is adopted as a raw material, lecithin, glyceride and poloxamer are adopted as drug carrying matrixes, the raw material medicine is mixed with the matrixes to form an oil phase and an oil-in-water phase, ultrasonic emulsification by a probe is carried out to obtain a nano mixed suspension, a dry-freezing agent is added to conduct dry freezing, and thus the lamiophlomis rotata extract nano dry suspension is prepared. The lamiophlomis rotata extract nano dry suspension prepared by using the method has a particle size of 40-180nm, has a large drug loading capacity, meanwhile, is remarkably improved in solubility and bioavailability of a hydrophobic drug terpene extract, stops bleeding and relieves pain and is definite in treatment effect.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a nano-preparation of unique herb extract and a preparation method thereof. Background technique [0002] Duyiwei is the dried whole herb of the genus Duyiwei in the family Lamiaceae. It is mainly distributed in Qinghai, Gansu, Sichuan and other provinces of China. It is a commonly used herbal medicine in Tibetan and Mongolian folk traditions. Promote blood circulation, promote stasis, reduce swelling, stop bleeding, and relieve pain. The main ingredients include iridoid glycosides, phenylethanol glycosides, and flavonoid glycosides. At present, the preparation process of various dosage forms including granules, capsules, dispersible tablets, effervescent tablets, and soft capsules has been disclosed in the existing patent technology of Duyiwei. Pharmacological effects of substances. For fat-soluble components such as shanzhiside methyl ester and 8-O-acet...

Claims

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Application Information

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IPC IPC(8): A61K36/53A61K9/19A61K47/10A61K47/14A61K47/24A61P7/04A61P29/00
CPCA61K9/19A61K36/53A61K47/10A61K47/14A61K47/24A61P7/04A61P29/00
Inventor 胡志文
Owner 江西杏林白马药业股份有限公司
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