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Preparation method of 2-amino-4-6-dimethyl pyrimidine

A technology of dimethylpyrimidine and amino, which is applied in the field of preparation of 2-amino-4-6-dimethylpyrimidine, can solve the problems that the reaction kettle cannot continue to maintain a constant temperature, the temperature is easy to lose, and the reaction is insufficient, so as to avoid The effect of excessive fluctuations in temperature

Inactive Publication Date: 2021-10-19
李万军
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] In the traditional synthesis process of 2-amino-4-6-dimethylpyrimidine, the reactor is usually used for reaction, and then transferred to the rest of the experimental equipment for reaction. Factors such as factors affect the results of the experiment, and the reactor cannot continue to maintain a constant temperature, which makes the reaction insufficient and affects the results of the experiment.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The present invention comprises the following components: 800 g of guanidine hydrochloride, 1000 g of acetylacetone, 1000 g of potassium carbonate, and 5000 g of water.

[0021] In order to further optimize the above-mentioned technical scheme, the preparation method is as follows:

[0022] S1: prepare the experimental instrument, and pretreat the instrument;

[0023] S2: The pretreated instruments include: reactor, SIMM microchannel reactor, 2PB-3020 advection pump, constant temperature bath;

[0024] S3: Guanidine hydrochloride, potassium carbonate, and water are injected into the reaction kettle by advection pump in proportion to react;

[0025] S4: Inject acetylacetone into the reaction kettle again, after reacting for 4h, obtain mixed solution A;

[0026] S5: The mixed solution A is sent to the SIMM microchannel reactor for further reaction by advection pumping, the temperature is lowered, and after crystallization for 2 hours, the mother liquor is suction-filter...

Embodiment 2

[0033] The present invention comprises the following components: guanidine hydrochloride 1000g, acetylacetone 1200g, potassium carbonate 1100g, water 7000g.

[0034] In order to further optimize the above-mentioned technical scheme, the preparation method is as follows:

[0035] S1: prepare the experimental instrument, and pretreat the instrument;

[0036] S2: The pretreated instruments include: reactor, SIMM microchannel reactor, 2PB-3020 advection pump, constant temperature bath;

[0037] S3: Guanidine hydrochloride, potassium carbonate, and water are injected into the reaction kettle by advection pump in proportion to react;

[0038] S4: Inject acetylacetone into the reaction kettle again, after reacting for 4h, obtain mixed solution A;

[0039] S5: The mixed solution A is sent to the SIMM microchannel reactor for further reaction by advection pumping, the temperature is lowered, and after crystallization for 2 hours, the mother liquor is suction-filtered to obtain white ...

Embodiment 3

[0046] The present invention comprises the following components: guanidine hydrochloride 956g, acetylacetone 1100g, potassium carbonate 1036g, water 6000g.

[0047] In order to further optimize the above-mentioned technical scheme, the preparation method is as follows:

[0048] S1: prepare the experimental instrument, and pretreat the instrument;

[0049] S2: The pretreated instruments include: reactor, SIMM microchannel reactor, 2PB-3020 advection pump, constant temperature bath;

[0050] S3: Guanidine hydrochloride, potassium carbonate, and water are injected into the reaction kettle by advection pump in proportion to react;

[0051] S4: Inject acetylacetone into the reaction kettle again, after reacting for 4h, obtain mixed solution A;

[0052] S5: The mixed solution A is sent to the SIMM microchannel reactor for further reaction by advection pumping, the temperature is lowered, and after crystallization for 2 hours, the mother liquor is suction-filtered to obtain white c...

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Abstract

The invention discloses a preparation method of 2-amino-4-6-dimethyl pyrimidine. The 2-amino-4-6-dimethyl pyrimidine comprises the following components by weight: 800 to 1000 g of guanidine hydrochloride, 1000 to 1200 g of acetylacetone, 1000 to 1100 g of potassium carbonate and 5000 to 7000 g of water. Experiments are carried out according to corresponding proportions, and meanwhile, the reaction kettle, the micro-channel reactor and the constant-flux pump are arranged in the constant-temperature bath, so that the situation that the temperature fluctuates too much up and down is avoided; and the situation that the experiment result and progress are affected by external factors in the reaction process is avoided by adopting a totally-closed channel for reaction.

Description

technical field [0001] The invention relates to a preparation method of 2-amino-4-6-dimethylpyrimidine. Background technique [0002] In the traditional synthesis process of 2-amino-4-6-dimethylpyrimidine, the reactor is usually used for reaction, and then transferred to the rest of the experimental equipment for reaction. Factors such as factors affect the results of the experiment, and the reactor cannot continue to maintain a constant temperature, which makes the reaction insufficient and affects the results of the experiment. [0003] Therefore, how to provide a method for preparing 2-amino-4-6-dimethylpyrimidine that can not only avoid being affected by external factors, but also maintain a constant temperature is an urgent problem to be solved by those skilled in the art. Contents of the invention [0004] In view of this, the present invention provides a method for preparing 2-amino-4-6-dimethylpyrimidine that can not only avoid being affected by external factors, ...

Claims

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Application Information

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IPC IPC(8): C07D239/42
CPCC07D239/42
Inventor 李万军
Owner 李万军
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