Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Pectin polysaccharide seleninic acid ester compound as well as preparation method and application thereof

A sugar selenite and polysaccharide-like technology, which can be applied in drug combinations, respiratory diseases, anti-toxins, etc., can solve the problems of poor therapeutic effect and no breakthrough in anti-inflammatory treatment, etc., and achieve significant therapeutic and protective effects Effect

Active Publication Date: 2021-10-26
CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
View PDF9 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

No breakthrough in anti-inflammatory therapy and poor efficacy of single drug therapy

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pectin polysaccharide seleninic acid ester compound as well as preparation method and application thereof
  • Pectin polysaccharide seleninic acid ester compound as well as preparation method and application thereof
  • Pectin polysaccharide seleninic acid ester compound as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0042] The present invention also provides the preparation method of the pectin polysaccharide selenite compound described in the above technical scheme, comprising the following steps:

[0043] Pectin polysaccharides and HNO 3 The aqueous solution is mixed to obtain a pectin polysaccharide solution;

[0044] Mixing the pectin polysaccharide solution and barium chloride to obtain a mixed solution;

[0045] Mix the mixture with Na 2 SeO 3 The solution is mixed for esterification to obtain a supernatant;

[0046] The supernatant is dialyzed to obtain the pectin polysaccharide selenite.

[0047] In the present invention, unless otherwise specified, the raw materials used are all commercially available products in this field.

[0048] The present invention combines pectin polysaccharide and HNO 3 The aqueous solution is mixed to obtain a pectin polysaccharide solution.

[0049] In the present invention, the pectin polysaccharide and HNO 3 The solid-to-liquid ratio of the a...

Embodiment 1

[0078] (1) Pectin polysaccharide (source: Seabuckthorn fruit, preparation method is with reference to the method in CN 104997034 A, the antioxidant seabuckthorn HG type pectin dietary fiber in CN104997034 A is recorded as the pectin polysaccharide used in this embodiment, structure is as follows Formula II, wherein n is 261, Mw is 91.87kDa, total sugar content is 92.3wt%, galacturonic acid content is 90.5wt%, protein content is 0.2wt%, and the configuration and glycosidic bond of sugar residues are mainly →1 )-β-D-GalpA-(4→), according to the ratio of solid to liquid 1:1 (mg / mL), add 0.1wt% concentration of HNO 3 aqueous solution, stirred (200 rpm) for 30 minutes to fully dissolve the pectin polysaccharides.

[0079] (2) Add BaCl according to the ratio of material to liquid 5:1 (mg / mL) 2 Powder, stirred (200 rpm) for 10 minutes, fully dissolved at room temperature;

[0080] (3) According to Na 2 SeO 3 Solution and pectin polysaccharide solution 1:20 volume ratio, drop 1mg / ...

Embodiment 2

[0091] (1) Pectin polysaccharide (source: apple, structure as shown in formula II, wherein n is 42, Mw is 14.78kDa, total sugar content 97.5wt%, galacturonic acid content 95.3wt%, protein content 0.1wt% , the configuration and glycosidic bond of sugar residues are mainly →1)-β-D-GalpA-(4→), according to the solid-liquid ratio of 20:1 (mg / mL), add 1.0wt% concentration of HNO 3 aqueous solution, stirred (500 rpm) for 10 minutes to fully dissolve the pectin polysaccharide.

[0092] (2) Add BaCl according to the ratio of solid to liquid 20:1 (mg / mL) 2 Powder, stirred (500 rpm) for 5 minutes, fully dissolved at room temperature;

[0093] (3) According to Na 2 SeO 3 Solution and pectin polysaccharide solution 1:10 volume ratio, drop 10mg / mL Na 2 SeO 3 Aqueous solution, at 60°C, stirred (500 rpm) for 12 hours;

[0094] (4) After the reaction solution was cooled to room temperature, anhydrous sodium carbonate powder was added to adjust the pH value of the solution to 6;

[0095...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
concentrationaaaaaaaaaa
Login to View More

Abstract

The invention provides a pectin polysaccharide seleninic acid ester compound as well as a preparation method and application thereof, which belongs to the technical field of organic synthesis. According to the pectin polysaccharide seleninic acid ester provided by the invention, pectin polysaccharide has remarkable antioxidant activity, can be complexed with heavy metal lead, has a protection effect on cell oxidative damage caused by heavy metal, and has a good research prospect of preventing and treating PM2.5 heavy metal damage. As an organic selenium compound, the pectin polysaccharide seleninic acid ester provided by the invention can give full play to the physiological activities of selenium and polysaccharide, so that the effects of selenium and polysaccharide are mutually coordinated and enhanced, and the biological activity is generally higher than that of single effects of polysaccharide and selenium.

Description

technical field [0001] The invention relates to the technical field of organic synthesis, in particular to a pectin polysaccharide selenite compound and its preparation method and application. Background technique [0002] Lead Pb is the main heavy metal pollution element in smog weather, which can cause damage to multiple systems of the human body, mainly including the nervous system, cardiovascular system, reproductive system, respiratory system, etc., and has certain carcinogenicity. Studies have shown that lead compounds in smog are introduced into the lungs through the respiratory system, which can cause substantial damage, oxidative damage, and inflammatory damage to the lungs, and can quickly enter the blood circulation, leading to an increase in blood lead levels and clinical manifestations. COPD symptoms. Moreover, the oxidative stress injury of alveolar epithelial cells caused by lead has been confirmed to be amplified through its bystander effect, resulting in mo...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/06A61P39/02A61P11/00
CPCC08B37/0045A61P39/02A61P11/00C08L5/06
Inventor 毕宏涛高婷婷魏立新李国强张明
Owner CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com