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Oral spray containing 10-HDA and preparation method thereof

A technology of 10-HDA and oral spray, which is applied in the direction of medical preparations containing active ingredients, aerosol delivery, and medical preparations with non-active ingredients. It can solve the problem that the antibacterial effect of traditional Chinese medicine compositions is limited and cannot Expected effects and other issues, to achieve the effect of promoting rapid repair, improving antibacterial effect, and improving quality of use

Inactive Publication Date: 2021-11-02
QILU UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the antibacterial effect of the traditional Chinese medicine composition of the invention is limited; patients widely use oral therapeutic drugs, and have developed drug resistance to these common drugs, which is far from the ideal expected effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A preparation method of an oral spray containing 10-HDA, comprising the steps of:

[0033] (1) Put 10g of honeysuckle, 10g of dandelion, 10g of Houttuynia cordata, and 10g of mint into a casserole, add 1000ml of distilled water, and soak for 20-30 minutes. After soaking, decoct on high heat, and switch to low heat for 15-20 minutes after boiling. Filter out the first decoction, then add 600ml of distilled water to the filter residue and decoct on high heat, after boiling, decoct on low heat for 15-20 minutes, filter out the second decoction; put the first and second filtrate Mix well, cool, filter, take the filtrate, and concentrate the filtrate to 600ml.

[0034] (2) Take 0.8g of sodium benzoate, 1.5g of 10-HDA, 2g of vitamin C, 1g of menthol, and 5g of sucrose, dissolve them in 400ml of sterile distilled water, and stir with a magnetic stirrer while heating until the ingredients are evenly mixed.

[0035] (3) Mix the solutions obtained in steps (1) and (2), and stir...

Embodiment 2

[0038] A preparation method of an oral spray containing 10-HDA, comprising the steps of:

[0039] (1) Put 10g of honeysuckle, 10g of dandelion, 10g of Houttuynia cordata, and 10g of mint into a casserole, add 1000ml of distilled water, and soak for 20-30 minutes. After soaking, decoct on high heat, and switch to low heat for 15-20 minutes after boiling. Filter out the first decoction, then add 600ml of distilled water to the filter residue and decoct on high heat, after boiling, decoct on low heat for 15-20 minutes, filter out the second decoction; put the first and second filtrate Mix well, cool, filter, take the filtrate, and concentrate the filtrate to 600ml.

[0040](2) Take 1g of sodium benzoate, 1.8g of 10-HDA, 2.5g of vitamin C, 1.5g of menthol, and 8g of sucrose, dissolve them in 400ml of sterile distilled water, and stir while heating with a magnetic stirrer until the ingredients are evenly mixed .

[0041] (3) Mix the solutions obtained in steps (1) and (2), and s...

Embodiment 3

[0044] A preparation method of an oral spray containing 10-HDA, comprising the steps of:

[0045] (1) Put 12g of honeysuckle, 12g of dandelion, 12g of Houttuynia cordata, and 12g of mint into a casserole, add 1000ml of distilled water, and soak for 20-30 minutes. After soaking, decoct on high heat, and switch to low heat for 15-20 minutes after boiling. Filter out the first decoction, then add 600ml of distilled water to the filter residue and decoct on high heat, after boiling, decoct on low heat for 15-20 minutes, filter out the second decoction; put the first and second filtrate Mix well, cool, filter, take the filtrate, and concentrate the filtrate to 600ml.

[0046] (2) Take 1g of sodium benzoate, 1.8g of 10-HDA, 2.5g of vitamin C, 1.5g of menthol, and 8g of sucrose, dissolve them in 400ml of sterile distilled water, and stir while heating with a magnetic stirrer until the ingredients are evenly mixed .

[0047] (3) Mix the solutions obtained in steps (1) and (2), and ...

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Abstract

The invention provides an oral spray containing 10-HDA and a preparation method thereof. The oral spray containing 10-HDA is prepared from the following raw materials in parts by weight: 8-15 parts of herba menthae, 8-15 parts of flos lonicerae, 8-15 parts of herba taraxaci, 8-15 parts of herba houttuyniae, 0.5-1.5 parts of sodium benzoate, 1 to 2 parts of 10-hydroxy-2-decenoic acid (10-HDA), 0.5-2 parts of menthol, 1-3 parts of vitamin C, 2-10 parts of cane sugar and 1500-2500 parts of water. The oral spray is prepared from 10-HDA and other important components, breeding of bacteria and microorganisms in the oral environment can be effectively resisted, the oral cavity is protected to a great extent, the disease state in the oral cavity is improved, normal repair of tissue in the oral cavity is promoted, and therefore human health is maintained.

Description

technical field [0001] The invention relates to a 10-HDA-containing oral spray and a preparation method thereof, belonging to the technical field of spray processing. Background technique [0002] Oral health is an important sign of a person's health, and it has a very important impact on the health of the whole body. However, various injuries, such as ulcers and wounds, often occur in the tissues of the oral cavity. Due to the complex environment in the oral cavity, there are many bacteria, which leads to slow wound healing. In this case, it is easy to affect the body's resistance and immunity. For this reason, various medicines or health care products for the treatment of oral diseases have rushed out on the market. However, due to the long-term and extensive use of these therapeutic drugs by patients, the bacteria in the oral cavity have already formed drug resistance. When these drugs are used again, the results are very unsatisfactory. Therefore, there is an urgent ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/78A61K9/12A61K31/201A61K47/12A61K47/26A61P29/00A61P1/02A61P7/04A61P31/04A61P31/02A61P31/12A61P11/00A61P11/14A61P39/02A61K31/045A61K31/375
CPCA61K36/534A61K36/355A61K36/288A61K36/78A61K31/201A61K31/045A61K31/375A61K9/006A61K47/12A61K47/26A61P29/00A61P1/02A61P7/04A61P31/04A61P31/02A61P31/12A61P11/00A61P11/14A61P39/02A61K2300/00
Inventor 苏静王丽王瑞明徐子淇王蕾蕾杨金硕吴文杰
Owner QILU UNIV OF TECH
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