Dissolvable microneedle spray production equipment and method

Abstract

The invention discloses a spraying production equipment of soluble microneedles, which comprises: a workbench; a microneedle mold, which is set on the workbench, has a plurality of microneedle cavities arranged horizontally at intervals, and two adjacent microneedle cavities A spacer is arranged between the needle cavities; an atomizing spray head is used to spray and fill the microneedle cavity with atomized polymer solution; a cover assembly is detachably connected with the microneedle mold. The invention discloses a spraying manufacturing method of a soluble microneedle. This production equipment uses an atomizing nozzle to spray and fill the microneedle cavity with the atomized polymer solution, and atomizes the polymer solution into micro-droplets with very small diameters, which can be easily filled to the bottom of the micro-needle cavity. The needle tip at the lower end forms a sharp needle tip shape, so that the micro-droplet fills the micro-needle cavity completely, and the produced micro-needle has a high-quality shape without loss of the polymer solution, which reduces the production cost.

Description

technical field [0001] The invention relates to the technology of transdermal drug delivery preparations, in particular to the injection manufacturing equipment and method of soluble microneedles. Background technique [0002] At present, the painless transdermal drug delivery of microneedles is a new drug delivery technology, which can painlessly create micron-scale drug delivery channels on the skin and enhance the skin's permeability to active substances or drugs, especially macromolecular drugs. , because of its painless, safe, and easy-to-operate advantages, it represents the future development direction of transdermal delivery of drugs into the body. [0003] Soluble microneedles are microneedles made of biodegradable materials. In addition to the advantages of general microneedles, their biodegradable properties solve the problem that once the microneedles break in the skin, it is difficult to deal with them. The extent is to increase the drug loading of microneedles...

AI Technical Summary

Problems solved by technology

Due to the centrifugal force or vacuum treatment process applied to the microneedle mold in the existing manufacturing method and the need to repeat the process, the instability of each batch of microneedle production limits its application in the industrialization of soluble microneedles. application

[0007] In addition, during the production process of the existing production equipment, the sprayed polymer solution is volatilized in the air, and a large amount of polymer solution will be lost, which is difficult to recycle. Because the polymer solution contains expensive pharmaceutical ingredients, the production cost is increased.

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